 Islets of Langerhans
"Islets of Langerhans" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Irregular microscopic structures consisting of cords of endocrine cells that are scattered throughout the PANCREAS among the exocrine acini. Each islet is surrounded by connective tissue fibers and penetrated by a network of capillaries. There are four major cell types. The most abundant beta cells (50-80%) secrete INSULIN. Alpha cells (5-20%) secrete GLUCAGON. PP cells (10-35%) secrete PANCREATIC POLYPEPTIDE. Delta cells (~5%) secrete SOMATOSTATIN.
| Descriptor ID |
D007515
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| MeSH Number(s) |
A03.734.414 A06.407.414
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| Concept/Terms |
Islets of Langerhans- Islets of Langerhans
- Langerhans Islets
- Pancreatic Islets
- Islet, Pancreatic
- Islets, Pancreatic
- Pancreatic Islet
- Nesidioblasts
- Nesidioblast
- Pancreas, Endocrine
- Endocrine Pancreas
- Islands of Langerhans
- Langerhans Islands
- Islet Cells
- Cell, Islet
- Cells, Islet
- Islet Cell
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Below are MeSH descriptors whose meaning is more general than "Islets of Langerhans".
Below are MeSH descriptors whose meaning is more specific than "Islets of Langerhans".
This graph shows the total number of publications written about "Islets of Langerhans" by people in this website by year, and whether "Islets of Langerhans" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
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| 1995 | 2 | 0 | 2 | | 1996 | 4 | 2 | 6 | | 1997 | 3 | 0 | 3 | | 1998 | 5 | 0 | 5 | | 1999 | 4 | 3 | 7 | | 2000 | 8 | 3 | 11 | | 2001 | 1 | 0 | 1 | | 2002 | 1 | 3 | 4 | | 2003 | 11 | 2 | 13 | | 2004 | 10 | 8 | 18 | | 2005 | 8 | 1 | 9 | | 2006 | 6 | 4 | 10 | | 2007 | 8 | 2 | 10 | | 2008 | 10 | 5 | 15 | | 2009 | 9 | 8 | 17 | | 2010 | 6 | 4 | 10 | | 2011 | 8 | 4 | 12 | | 2012 | 6 | 6 | 12 | | 2013 | 8 | 8 | 16 | | 2014 | 13 | 8 | 21 | | 2015 | 11 | 2 | 13 | | 2016 | 9 | 3 | 12 | | 2017 | 12 | 3 | 15 | | 2018 | 16 | 8 | 24 | | 2019 | 12 | 8 | 20 | | 2020 | 8 | 5 | 13 | | 2021 | 21 | 9 | 30 | | 2022 | 15 | 1 | 16 | | 2023 | 16 | 0 | 16 | | 2024 | 0 | 2 | 2 |
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Below are the most recent publications written about "Islets of Langerhans" by people in Profiles.
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Phillip M, Achenbach P, Addala A, Albanese-O'Neill A, Battelino T, Bell KJ, Besser REJ, Bonifacio E, Colhoun HM, Couper JJ, Craig ME, Danne T, de Beaufort C, Dovc K, Driscoll KA, Dutta S, Ebekozien O, Larsson HE, Feiten DJ, Frohnert BI, Gabbay RA, Gallagher MP, Greenbaum CJ, Griffin KJ, Hagopian W, Haller MJ, Hendrieckx C, Hendriks E, Holt RIG, Hughes L, Ismail HM, Jacobsen LM, Johnson SB, Kolb LE, Kordonouri O, Lange K, Lash RW, Lernmark ?, Libman I, Lundgren M, Maahs DM, Marcovecchio ML, Mathieu C, Miller KM, O'Donnell HK, Oron T, Patil SP, Pop-Busui R, Rewers MJ, Rich SS, Schatz DA, Schulman-Rosenbaum R, Simmons KM, Sims EK, Skyler JS, Smith LB, Speake C, Steck AK, Thomas NPB, Tonyushkina KN, Veijola R, Wentworth JM, Wherrett DK, Wood JR, Ziegler AG, DiMeglio LA. Consensus guidance for monitoring individuals with islet autoantibody-positive pre-stage 3 type 1 diabetes. Diabetologia. 2024 Sep; 67(9):1731-1759.
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Phillip M, Achenbach P, Addala A, Albanese-O'Neill A, Battelino T, Bell KJ, Besser REJ, Bonifacio E, Colhoun HM, Couper JJ, Craig ME, Danne T, de Beaufort C, Dovc K, Driscoll KA, Dutta S, Ebekozien O, Elding Larsson H, Feiten DJ, Frohnert BI, Gabbay RA, Gallagher MP, Greenbaum CJ, Griffin KJ, Hagopian W, Haller MJ, Hendrieckx C, Hendriks E, Holt RIG, Hughes L, Ismail HM, Jacobsen LM, Johnson SB, Kolb LE, Kordonouri O, Lange K, Lash RW, Lernmark ?, Libman I, Lundgren M, Maahs DM, Marcovecchio ML, Mathieu C, Miller KM, O'Donnell HK, Oron T, Patil SP, Pop-Busui R, Rewers MJ, Rich SS, Schatz DA, Schulman-Rosenbaum R, Simmons KM, Sims EK, Skyler JS, Smith LB, Speake C, Steck AK, Thomas NPB, Tonyushkina KN, Veijola R, Wentworth JM, Wherrett DK, Wood JR, Ziegler AG, DiMeglio LA. Consensus Guidance for Monitoring Individuals With Islet Autoantibody-Positive Pre-Stage 3 Type 1 Diabetes. Diabetes Care. 2024 Aug 01; 47(8):1276-1298.
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Mitchell AM, Baschal EE, McDaniel KA, Fleury T, Choi H, Pyle L, Yu L, Rewers MJ, Nakayama M, Michels AW. Tracking DNA-based antigen-specific T cell receptors during progression to type 1 diabetes. Sci Adv. 2023 Dec 08; 9(49):eadj6975.
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O'Donnell HK, Rasmussen CG, Dong F, Simmons KM, Steck AK, Frohnert BI, Bautista K, Rewers MJ, Baxter J. Anxiety and Risk Perception in Parents of Children Identified by Population Screening as High Risk for Type 1 Diabetes. Diabetes Care. 2023 Dec 01; 46(12):2155-2161.
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Briggs JK, Gresch A, Marinelli I, Dwulet JM, Albers DJ, Kravets V, Benninger RKP. ?-cell intrinsic dynamics rather than gap junction structure dictates subpopulations in the islet functional network. Elife. 2023 Nov 29; 12.
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Lin J, Moradi E, Salenius K, Lehtipuro S, H?kkinen T, Laiho JE, Oikarinen S, Randelin S, Parikh HM, Krischer JP, Toppari J, Lernmark ?, Petrosino JF, Ajami NJ, She JX, Hagopian WA, Rewers MJ, Lloyd RE, Rautajoki KJ, Hy?ty H, Nykter M. Distinct transcriptomic profiles in children prior to the appearance of type 1 diabetes-linked islet autoantibodies and following enterovirus infection. Nat Commun. 2023 Nov 22; 14(1):7630.
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L?nnrot M, Lynch KF, Rewers M, Lernmark ?, Vehik K, Akolkar B, Hagopian W, Krischer J, McIndoe RA, Toppari J, Ziegler AG, Petrosino JF, Lloyd R, Hy?ty H. Gastrointestinal Infections Modulate the Risk for Insulin Autoantibodies as the First-Appearing Autoantibody in the TEDDY Study. Diabetes Care. 2023 11 01; 46(11):1908-1915.
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Frohnert BI, Ghalwash M, Li Y, Ng K, Dunne JL, Lundgren M, Hagopian W, Lou O, Winkler C, Toppari J, Veijola R, Anand V. Refining the Definition of Stage 1 Type 1 Diabetes: An Ontology-Driven Analysis of the Heterogeneity of Multiple Islet Autoimmunity. Diabetes Care. 2023 10 01; 46(10):1753-1761.
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Uusitalo U, Mramba LK, Aronsson CA, Vehik K, Yang J, Hummel S, Lernmark ?, Rewers M, Hagopian W, McIndoe R, Toppari J, Ziegler AG, Akolkar B, Krischer JP, Virtanen SM, Norris JM. HLA Genotype and Probiotics Modify the Association Between Timing of Solid Food Introduction and Islet Autoimmunity in the TEDDY Study. Diabetes Care. 2023 10 01; 46(10):1839-1847.
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St Clair JR, Westacott MJ, Miranda J, Farnsworth NL, Kravets V, Schleicher WE, Dwulet JM, Levitt CH, Heintz A, Ludin NWF, Benninger RKP. Restoring connexin-36 function in diabetogenic environments precludes mouse and human islet dysfunction. J Physiol. 2023 09; 601(18):4053-4072.
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