 Complement C3
"Complement C3" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A glycoprotein that is central in both the classical and the alternative pathway of COMPLEMENT ACTIVATION. C3 can be cleaved into COMPLEMENT C3A and COMPLEMENT C3B, spontaneously at low level or by C3 CONVERTASE at high level. The smaller fragment C3a is an ANAPHYLATOXIN and mediator of local inflammatory process. The larger fragment C3b binds with C3 convertase to form C5 convertase.
| Descriptor ID |
D003176
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| MeSH Number(s) |
D12.776.124.050.140 D12.776.124.486.274.250
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| Concept/Terms |
Complement C3- Complement C3
- C3, Complement
- Complement 3
- Complement Component 3
- Component 3, Complement
- C3 Complement
- Complement, C3
Complement C3 Precursor- Complement C3 Precursor
- C3 Precursor, Complement
- Precursor, Complement C3
- Pro-C3
- Pro C3
- Precursor-Complement 3
- Precursor Complement 3
- Pro-Complement 3
- Pro Complement 3
- C3 Precursor
- Precursor, C3
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Below are MeSH descriptors whose meaning is more general than "Complement C3".
Below are MeSH descriptors whose meaning is more specific than "Complement C3".
This graph shows the total number of publications written about "Complement C3" by people in this website by year, and whether "Complement C3" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1992 | 2 | 1 | 3 | | 1993 | 0 | 5 | 5 | | 1994 | 0 | 1 | 1 | | 1995 | 0 | 1 | 1 | | 1996 | 0 | 3 | 3 | | 1997 | 2 | 1 | 3 | | 2000 | 1 | 2 | 3 | | 2001 | 2 | 2 | 4 | | 2002 | 1 | 4 | 5 | | 2003 | 1 | 3 | 4 | | 2004 | 1 | 3 | 4 | | 2005 | 0 | 2 | 2 | | 2006 | 2 | 2 | 4 | | 2007 | 2 | 3 | 5 | | 2008 | 3 | 2 | 5 | | 2009 | 0 | 1 | 1 | | 2011 | 3 | 4 | 7 | | 2012 | 0 | 2 | 2 | | 2013 | 3 | 6 | 9 | | 2014 | 2 | 1 | 3 | | 2015 | 3 | 1 | 4 | | 2016 | 4 | 1 | 5 | | 2017 | 2 | 5 | 7 | | 2018 | 4 | 2 | 6 | | 2019 | 1 | 2 | 3 | | 2020 | 1 | 3 | 4 | | 2021 | 0 | 1 | 1 |
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Below are the most recent publications written about "Complement C3" by people in Profiles.
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Laskowski J, Thurman JM. Complement Detection in Mouse Kidneys by Immunofluorescence. Methods Mol Biol. 2021; 2227:179-189.
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Fan X, McCullough RL, Huang E, Bellar A, Kim A, Poulsen KL, McClain CJ, Mitchell M, McCullough AJ, Radaeva S, Barton B, Szabo G, Dasarathy S, Rotroff DM, Nagy LE. Diagnostic and Prognostic Significance of Complement in Patients With Alcohol-Associated Hepatitis. Hepatology. 2021 03; 73(3):983-997.
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Chen JY, Galwankar NS, Emch HN, Menon SS, Cortes C, Thurman JM, Merrill SA, Brodsky RA, Ferreira VP. Properdin Is a Key Player in Lysis of Red Blood Cells and Complement Activation on Endothelial Cells in Hemolytic Anemias Caused by Complement Dysregulation. Front Immunol. 2020; 11:1460.
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Gaikwad H, Li Y, Gifford G, Groman E, Banda NK, Saba L, Scheinman R, Wang G, Simberg D. Complement Inhibitors Block Complement C3 Opsonization and Improve Targeting Selectivity of Nanoparticles in Blood. Bioconjug Chem. 2020 07 15; 31(7):1844-1856.
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Frid MG, McKeon BA, Thurman JM, Maron BA, Li M, Zhang H, Kumar S, Sullivan T, Laskowsky J, Fini MA, Hu S, Tuder RM, Gandjeva A, Wilkins MR, Rhodes CJ, Ghataorhe P, Leopold JA, Wang RS, Holers VM, Stenmark KR. Immunoglobulin-driven Complement Activation Regulates Proinflammatory Remodeling in Pulmonary Hypertension. Am J Respir Crit Care Med. 2020 01 15; 201(2):224-239.
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Chisholm CF, Behnke W, Pokhilchuk Y, Frazer-Abel AA, Randolph TW. Subvisible Particles in IVIg Formulations Activate Complement in Human Serum. J Pharm Sci. 2020 01; 109(1):558-565.
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Foss CA, Kulik L, Ordonez AA, Jain SK, Michael Holers V, Thurman JM, Pomper MG. SPECT/CT Imaging of Mycobacterium tuberculosis Infection with [125I]anti-C3d mAb. Mol Imaging Biol. 2019 06; 21(3):473-481.
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Vu VP, Gifford GB, Chen F, Benasutti H, Wang G, Groman EV, Scheinman R, Saba L, Moghimi SM, Simberg D. Immunoglobulin deposition on biomolecule corona determines complement opsonization efficiency of preclinical and clinical nanoparticles. Nat Nanotechnol. 2019 03; 14(3):260-268.
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Kurdi M, Zgheib C, Booz GW. Recent Developments on the Crosstalk Between STAT3 and Inflammation in Heart Function and Disease. Front Immunol. 2018; 9:3029.
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Gralinski LE, Sheahan TP, Morrison TE, Menachery VD, Jensen K, Leist SR, Whitmore A, Heise MT, Baric RS. Complement Activation Contributes to Severe Acute Respiratory Syndrome Coronavirus Pathogenesis. mBio. 2018 10 09; 9(5).
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