Structure-Activity Relationship
"Structure-Activity Relationship" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.
Descriptor ID |
D013329
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MeSH Number(s) |
G02.111.830 G07.690.773.997
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Concept/Terms |
Structure-Activity Relationship- Structure-Activity Relationship
- Relationship, Structure-Activity
- Relationships, Structure-Activity
- Structure Activity Relationship
- Structure-Activity Relationships
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Below are MeSH descriptors whose meaning is more general than "Structure-Activity Relationship".
Below are MeSH descriptors whose meaning is more specific than "Structure-Activity Relationship".
This graph shows the total number of publications written about "Structure-Activity Relationship" by people in this website by year, and whether "Structure-Activity Relationship" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
Year | Major Topic | Minor Topic | Total |
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1994 | 0 | 7 | 7 | 1995 | 0 | 6 | 6 | 1996 | 0 | 13 | 13 | 1997 | 0 | 7 | 7 | 1998 | 0 | 5 | 5 | 1999 | 0 | 7 | 7 | 2000 | 0 | 10 | 10 | 2001 | 0 | 5 | 5 | 2002 | 0 | 15 | 15 | 2003 | 0 | 12 | 12 | 2004 | 0 | 11 | 11 | 2005 | 0 | 10 | 10 | 2006 | 0 | 17 | 17 | 2007 | 0 | 18 | 18 | 2008 | 0 | 9 | 9 | 2009 | 0 | 13 | 13 | 2010 | 0 | 12 | 12 | 2011 | 0 | 18 | 18 | 2012 | 0 | 19 | 19 | 2013 | 0 | 11 | 11 | 2014 | 0 | 5 | 5 | 2015 | 0 | 12 | 12 | 2016 | 1 | 14 | 15 | 2017 | 1 | 16 | 17 | 2018 | 0 | 21 | 21 | 2019 | 0 | 15 | 15 | 2020 | 0 | 14 | 14 | 2021 | 0 | 16 | 16 | 2022 | 0 | 4 | 4 | 2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "Structure-Activity Relationship" by people in Profiles.
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Weig AW, O'Conner PM, Kwiecinski JM, Marciano OM, Nunag A, Gutierrez AT, Melander RJ, Horswill AR, Melander C. A structure activity relationship study of 3,4'-dimethoxyflavone for ArlRS inhibition in Staphylococcus aureus. Org Biomol Chem. 2023 04 26; 21(16):3373-3380.
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El-Khouly OA, Henen MA, El-Sayed MA, El-Messery SM. Design, synthesis and computational study of new benzofuran hybrids as dual PI3K/VEGFR2 inhibitors targeting cancer. Sci Rep. 2022 10 12; 12(1):17104.
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Nashaat S, Henen MA, El-Messery SM, Eisa H. New Benzimidazoles Targeting Breast Cancer: Synthesis, Pin1 Inhibition, 2D NMR Binding, and Computational Studies. Molecules. 2022 Aug 17; 27(16).
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Rudolph J, Jung K, Luger K. Inhibitors of PARP: Number crunching and structure gazing. Proc Natl Acad Sci U S A. 2022 03 15; 119(11):e2121979119.
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Shepard JD, Freitas BT, Rodriguez SE, Scholte FEM, Baker K, Hutchison MR, Longo JE, Miller HC, O'Boyle BM, Tandon A, Zhao P, Grimsey NJ, Wells L, Bergeron ?, Pegan SD. The Structure and Immune Regulatory Implications of the Ubiquitin-Like Tandem Domain Within an Avian 2'-5' Oligoadenylate Synthetase-Like Protein. Front Immunol. 2021; 12:794664.
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Iragavarapu AG, Yao L, Kasinath V. Structural insights into the interactions of Polycomb Repressive Complex 2 with chromatin. Biochem Soc Trans. 2021 12 17; 49(6):2639-2653.
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Anantharajan J, Baburajendran N, Lin G, Loh YY, Xu W, Ahmad NHB, Liu S, Jansson AE, Kuan JWL, Ng EY, Yeo YK, Hung AW, Joy J, Hill J, Ford HL, Zhao R, Keller TH, Kang C. Structure-activity relationship studies of allosteric inhibitors of EYA2 tyrosine phosphatase. Protein Sci. 2022 02; 31(2):422-431.
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Kumar V, Dhawan S, Girase PS, Awolade P, Shinde SR, Karpoormath R, Singh P. Recent Advances in Chalcone-Based Anticancer Heterocycles: A Structural and Molecular Target Perspective. Curr Med Chem. 2021 Oct 25; 28(33):6805-6845.
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Chen Z, Song K, Shang Y, Xiong Y, Lyu Z, Chen J, Zheng J, Li P, Wu Y, Gu C, Xie Y, Deng Q, Yu Z, Zhang J, Qu D. Selection and Identification of Novel Antibacterial Agents against Planktonic Growth and Biofilm Formation of Enterococcus faecalis. J Med Chem. 2021 10 28; 64(20):15037-15052.
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Wahid AA, Dunphy RW, Macpherson A, Gibson BG, Kulik L, Whale K, Back C, Hallam TM, Alkhawaja B, Martin RL, Meschede I, Laabei M, Lawson ADG, Holers VM, Watts AG, Crennell SJ, Harris CL, Marchbank KJ, van den Elsen JMH. Insights Into the Structure-Function Relationships of Dimeric C3d Fragments. Front Immunol. 2021; 12:714055.
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