 Activating Transcription Factor 4
"Activating Transcription Factor 4" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An activating transcription factor that regulates the expression of a variety of GENES involved in amino acid metabolism and transport. It also interacts with HTLV-I transactivator protein.
| Descriptor ID |
D051701
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| MeSH Number(s) |
D12.776.260.108.061.937 D12.776.930.127.061.937
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| Concept/Terms |
Activating Transcription Factor 4- Activating Transcription Factor 4
- ATF4 Transcription Factor
- Transcription Factor, ATF4
- Tax-Responsive Enhancer Element B67
- Tax Responsive Enhancer Element B67
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Below are MeSH descriptors whose meaning is more general than "Activating Transcription Factor 4".
Below are MeSH descriptors whose meaning is more specific than "Activating Transcription Factor 4".
This graph shows the total number of publications written about "Activating Transcription Factor 4" by people in this website by year, and whether "Activating Transcription Factor 4" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 0 | 1 | 1 | | 2007 | 0 | 1 | 1 | | 2011 | 0 | 1 | 1 | | 2012 | 1 | 1 | 2 | | 2013 | 1 | 0 | 1 | | 2016 | 1 | 0 | 1 | | 2018 | 0 | 1 | 1 | | 2019 | 0 | 1 | 1 | | 2021 | 0 | 1 | 1 |
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Below are the most recent publications written about "Activating Transcription Factor 4" by people in Profiles.
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Yang C, Tian C, Hoffman TE, Jacobsen NK, Spencer SL. Melanoma subpopulations that rapidly escape MAPK pathway inhibition incur DNA damage and rely on stress signalling. Nat Commun. 2021 03 19; 12(1):1747.
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Augusto L, Amin PH, Wek RC, Sullivan WJ. Regulation of arginine transport by GCN2 eIF2 kinase is important for replication of the intracellular parasite Toxoplasma gondii. PLoS Pathog. 2019 06; 15(6):e1007746.
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Cormerais Y, Pagnuzzi-Boncompagni M, Schrötter S, Giuliano S, Tambutté E, Endou H, Wempe MF, Pagès G, Pouysségur J, Picco V. Inhibition of the amino-acid transporter LAT1 demonstrates anti-neoplastic activity in medulloblastoma. J Cell Mol Med. 2019 04; 23(4):2711-2718.
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Shiozaki Y, Okamura K, Kohno S, Keenan AL, Williams K, Zhao X, Chick WS, Miyazaki-Anzai S, Miyazaki M. The CDK9-cyclin T1 complex mediates saturated fatty acid-induced vascular calcification by inducing expression of the transcription factor CHOP. J Biol Chem. 2018 11 02; 293(44):17008-17020.
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Adams CM, Ebert SM, Dyle MC. Role of ATF4 in skeletal muscle atrophy. Curr Opin Clin Nutr Metab Care. 2017 May; 20(3):164-168.
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Masuda M, Miyazaki-Anzai S, Keenan AL, Shiozaki Y, Okamura K, Chick WS, Williams K, Zhao X, Rahman SM, Tintut Y, Adams CM, Miyazaki M. Activating transcription factor-4 promotes mineralization in vascular smooth muscle cells. JCI Insight. 2016 11 03; 1(18):e88646.
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Ebert SM, Dyle MC, Bullard SA, Dierdorff JM, Murry DJ, Fox DK, Bongers KS, Lira VA, Meyerholz DK, Talley JJ, Adams CM. Identification and Small Molecule Inhibition of an Activating Transcription Factor 4 (ATF4)-dependent Pathway to Age-related Skeletal Muscle Weakness and Atrophy. J Biol Chem. 2015 Oct 16; 290(42):25497-511.
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Fox DK, Ebert SM, Bongers KS, Dyle MC, Bullard SA, Dierdorff JM, Kunkel SD, Adams CM. p53 and ATF4 mediate distinct and additive pathways to skeletal muscle atrophy during limb immobilization. Am J Physiol Endocrinol Metab. 2014 Aug 01; 307(3):E245-61.
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Masuda M, Miyazaki-Anzai S, Levi M, Ting TC, Miyazaki M. PERK-eIF2a-ATF4-CHOP signaling contributes to TNFa-induced vascular calcification. J Am Heart Assoc. 2013 Sep 05; 2(5):e000238.
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Bongers KS, Fox DK, Ebert SM, Kunkel SD, Dyle MC, Bullard SA, Dierdorff JM, Adams CM. Skeletal muscle denervation causes skeletal muscle atrophy through a pathway that involves both Gadd45a and HDAC4. Am J Physiol Endocrinol Metab. 2013 Oct 01; 305(7):E907-15.
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