 Activating Transcription Factor 4
"Activating Transcription Factor 4" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An activating transcription factor that regulates the expression of a variety of GENES involved in amino acid metabolism and transport. It also interacts with HTLV-I transactivator protein.
| Descriptor ID |
D051701
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| MeSH Number(s) |
D12.776.260.108.061.937 D12.776.930.127.061.937
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| Concept/Terms |
Activating Transcription Factor 4- Activating Transcription Factor 4
- ATF4 Transcription Factor
- Transcription Factor, ATF4
- Tax-Responsive Enhancer Element B67
- Tax Responsive Enhancer Element B67
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Below are MeSH descriptors whose meaning is more general than "Activating Transcription Factor 4".
Below are MeSH descriptors whose meaning is more specific than "Activating Transcription Factor 4".
This graph shows the total number of publications written about "Activating Transcription Factor 4" by people in this website by year, and whether "Activating Transcription Factor 4" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 0 | 1 | 1 | | 2007 | 0 | 1 | 1 | | 2011 | 0 | 1 | 1 | | 2012 | 1 | 1 | 2 | | 2013 | 1 | 0 | 1 | | 2016 | 1 | 0 | 1 | | 2018 | 1 | 1 | 2 | | 2021 | 1 | 2 | 3 | | 2023 | 0 | 1 | 1 | | 2025 | 1 | 0 | 1 |
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Below are the most recent publications written about "Activating Transcription Factor 4" by people in Profiles.
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Schiavon A, Saba L, Evaristo C, Petiti J, Pignochino Y, Ferrero G, Giordano G, Tucciarello C, Puglisi S, Reimondo G, Terzolo M, Lo Iacono M. Mitotane activates ATF4/ATF3 axis triggering endoplasmic reticulum stress in adrenocortical carcinoma cells. Biomed Pharmacother. 2025 Mar; 184:117917.
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Ludwig MP, Galbraith MD, Eduthan NP, Hill AA, Clay MR, Tellez CM, Wilky BA, Elias A, Espinosa JM, Sullivan KD. Proteasome Inhibition Sensitizes Liposarcoma to MDM2 Inhibition with Nutlin-3 by Activating the ATF4/CHOP Stress Response Pathway. Cancer Res. 2023 08 01; 83(15):2543-2556.
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Miyazaki-Anzai S, Masuda M, Shiozaki Y, Keenan AL, Chonchol M, Kremoser C, Miyazaki M. Free Deoxycholic Acid Exacerbates Vascular Calcification in CKD through ER Stress-Mediated ATF4 Activation. Kidney360. 2021 May; 2(5):857-868.
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Jonsson WO, Margolies NS, Mirek ET, Zhang Q, Linden MA, Hill CM, Link C, Bithi N, Zalma B, Levy JL, Pettit AP, Miller JW, Hine C, Morrison CD, Gettys TW, Miller BF, Hamilton KL, Wek RC, Anthony TG. Physiologic Responses to Dietary Sulfur Amino Acid Restriction in Mice Are Influenced by Atf4 Status and Biological Sex. J Nutr. 2021 04 08; 151(4):785-799.
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Yang C, Tian C, Hoffman TE, Jacobsen NK, Spencer SL. Melanoma subpopulations that rapidly escape MAPK pathway inhibition incur DNA damage and rely on stress signalling. Nat Commun. 2021 03 19; 12(1):1747.
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Augusto L, Amin PH, Wek RC, Sullivan WJ. Regulation of arginine transport by GCN2 eIF2 kinase is important for replication of the intracellular parasite Toxoplasma gondii. PLoS Pathog. 2019 06; 15(6):e1007746.
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Cormerais Y, Pagnuzzi-Boncompagni M, Schr?tter S, Giuliano S, Tambutt? E, Endou H, Wempe MF, Pag?s G, Pouyss?gur J, Picco V. Inhibition of the amino-acid transporter LAT1 demonstrates anti-neoplastic activity in medulloblastoma. J Cell Mol Med. 2019 04; 23(4):2711-2718.
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Krishnamoorthy GP, Davidson NR, Leach SD, Zhao Z, Lowe SW, Lee G, Landa I, Nagarajah J, Saqcena M, Singh K, Wendel HG, Dogan S, Tamarapu PP, Blenis J, Ghossein RA, Knauf JA, R?tsch G, Fagin JA. EIF1AX and RAS Mutations Cooperate to Drive Thyroid Tumorigenesis through ATF4 and c-MYC. Cancer Discov. 2019 02; 9(2):264-281.
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Shiozaki Y, Okamura K, Kohno S, Keenan AL, Williams K, Zhao X, Chick WS, Miyazaki-Anzai S, Miyazaki M. The CDK9-cyclin T1 complex mediates saturated fatty acid-induced vascular calcification by inducing expression of the transcription factor CHOP. J Biol Chem. 2018 11 02; 293(44):17008-17020.
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Adams CM, Ebert SM, Dyle MC. Role of ATF4 in skeletal muscle atrophy. Curr Opin Clin Nutr Metab Care. 2017 May; 20(3):164-168.
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