Off-Label Use
"Off-Label Use" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The practice of prescribing or using a drug outside the scope of the drug's official approved label as designated by a regulatory agency concerning the treatment of a particular disease or condition.
Descriptor ID |
D056687
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MeSH Number(s) |
E02.319.307.500
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Concept/Terms |
Off-Label Use- Off-Label Use
- Off Label Use
- Off-Label Uses
- Use, Off-Label
- Uses, Off-Label
- Off-Label Prescribing
- Off Label Prescribing
- Off-Label Prescribings
- Prescribing, Off-Label
- Prescribings, Off-Label
- Unlabeled Indication
- Indication, Unlabeled
- Indications, Unlabeled
- Unlabeled Indications
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Below are MeSH descriptors whose meaning is more general than "Off-Label Use".
Below are MeSH descriptors whose meaning is more specific than "Off-Label Use".
This graph shows the total number of publications written about "Off-Label Use" by people in this website by year, and whether "Off-Label Use" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
Year | Major Topic | Minor Topic | Total |
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2009 | 2 | 1 | 3 | 2011 | 1 | 0 | 1 | 2012 | 2 | 1 | 3 | 2013 | 0 | 2 | 2 | 2014 | 2 | 0 | 2 | 2015 | 1 | 2 | 3 | 2016 | 0 | 1 | 1 | 2017 | 2 | 5 | 7 | 2018 | 2 | 0 | 2 | 2019 | 0 | 3 | 3 | 2020 | 1 | 1 | 2 | 2021 | 1 | 1 | 2 | 2022 | 0 | 2 | 2 | 2023 | 1 | 1 | 2 |
To return to the timeline, click here.
Below are the most recent publications written about "Off-Label Use" by people in Profiles.
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Sandhu A, Kaltenbach LA, Chiswell K, Shimoga V, Ashur C, Pribish A, Fonarow GC, Piccini JP, Ho PM, Varosy PD, Hess PL. Off-Label Dosing of Direct Oral Anticoagulants Among Inpatients With Atrial Fibrillation in the United States. Circ Cardiovasc Qual Outcomes. 2023 12; 16(12):e010062.
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Gazarian M, Horton DB, Carleton B, Kinlaw AC, Bushnell GA, Czaja AS, Durrieu G, Gorman EF, Titievsky L, Zito J, Slaughter JL, dosReis S. Optimizing therapeutic decision-making for off-label medicines use: A scoping review and consensus recommendations for improving practice and research. Pharmacoepidemiol Drug Saf. 2023 11; 32(11):1200-1222.
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Szmuilowicz ED, Levy CJ, Buschur EO, Polsky S. Expert Guidance on Off-Label Use of Hybrid Closed-Loop Therapy in Pregnancies Complicated by Diabetes. Diabetes Technol Ther. 2023 05; 25(5):363-373.
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Kelsey MM, Zeitler PS, Nadeau KJ, Shah AS. Type 2 diabetes in youth: Rationale for use of off-label antidiabetic agents. Pediatr Diabetes. 2022 09; 23(6):615-619.
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Rodriguez LE, Eun JC, Calkins RT, Carroll AM, Malgor EA, Wohlauer MV, Nehler MR, Jacobs DL, Malgor RD. Comparison Study of Iliac Branch Endoprosthesis when Used on and off Label. Ann Vasc Surg. 2023 Feb; 89:28-35.
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Hughes MS, Bailey R, Calhoun P, Shah VN, Lyons SK, DeSalvo DJ. Off-label use of sodium glucose co-transporter inhibitors among adults in type 1 diabetes exchange registry. Diabetes Obes Metab. 2022 01; 24(1):171-173.
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San Giovanni CB, Sweeney B, Skelton JA, Kelsey MM, Kelly AS. Aversion to Off-label Prescribing in Clinical Pediatric Weight Management: The Quintessential Double Standard. J Clin Endocrinol Metab. 2021 06 16; 106(7):2103-2113.
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Boguniewicz M. Biologics for Atopic Dermatitis. Immunol Allergy Clin North Am. 2020 11; 40(4):593-607.
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Kisor DF, Monte AA, M?ller DJ. Pharmacogenetic associations and evidence-based pharmacogenomics guidelines: supporting label and off-label use of drug-gene interaction data. Pharmacogenomics. 2020 05; 21(7):427-430.
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Oleszek JL, Kanallakan AS, Powell AJ. Out of the spasticity box: Off-label uses of botulinum toxin in children. J Pediatr Rehabil Med. 2020; 13(2):205-207.
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