 Protein Isoforms
"Protein Isoforms" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Different forms of a protein that may be produced from different GENES, or from the same gene by ALTERNATIVE SPLICING.
| Descriptor ID |
D020033
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| MeSH Number(s) |
D12.776.800
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Protein Isoforms".
Below are MeSH descriptors whose meaning is more specific than "Protein Isoforms".
This graph shows the total number of publications written about "Protein Isoforms" by people in this website by year, and whether "Protein Isoforms" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 | | 1999 | 1 | 4 | 5 | | 2000 | 1 | 8 | 9 | | 2001 | 1 | 9 | 10 | | 2002 | 1 | 7 | 8 | | 2003 | 1 | 10 | 11 | | 2004 | 0 | 11 | 11 | | 2005 | 2 | 10 | 12 | | 2006 | 0 | 11 | 11 | | 2007 | 0 | 4 | 4 | | 2008 | 1 | 9 | 10 | | 2009 | 0 | 9 | 9 | | 2010 | 2 | 6 | 8 | | 2011 | 0 | 4 | 4 | | 2012 | 0 | 9 | 9 | | 2013 | 0 | 5 | 5 | | 2014 | 0 | 5 | 5 | | 2015 | 1 | 8 | 9 | | 2016 | 1 | 4 | 5 | | 2017 | 1 | 5 | 6 | | 2018 | 2 | 9 | 11 | | 2019 | 0 | 8 | 8 | | 2020 | 0 | 5 | 5 | | 2021 | 1 | 2 | 3 |
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Below are the most recent publications written about "Protein Isoforms" by people in Profiles.
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Levandowski CB, Jones T, Gruca M, Ramamoorthy S, Dowell RD, Taatjes DJ. The ?40p53 isoform inhibits p53-dependent eRNA transcription and enables regulation by signal-specific transcription factors during p53 activation. PLoS Biol. 2021 08; 19(8):e3001364.
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Perni S, Beam K. Neuronal junctophilins recruit specific CaV and RyR isoforms to ER-PM junctions and functionally alter CaV2.1 and CaV2.2. Elife. 2021 03 26; 10.
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Han Y, Wood SD, Wright JM, Dostal V, Lau E, Lam MPY. Computation-assisted targeted proteomics of alternative splicing protein isoforms in the human heart. J Mol Cell Cardiol. 2021 05; 154:92-96.
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Wong H, Levenga J, LaPlante L, Keller B, Cooper-Sansone A, Borski C, Milstead R, Ehringer M, Hoeffer C. Isoform-specific roles for AKT in affective behavior, spatial memory, and extinction related to psychiatric disorders. Elife. 2020 12 16; 9.
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Guo H, Zhang Q, Dai R, Yu B, Hoekzema K, Tan J, Tan S, Jia X, Chung WK, Hernan R, Alkuraya FS, Alsulaiman A, Al-Muhaizea MA, Lesca G, Pons L, Labalme A, Laux L, Bryant E, Brown NJ, Savva E, Ayres S, Eratne D, Peeters H, Bilan F, Letienne-Cejudo L, Gilbert-Dussardier B, Ruiz-Arana IL, Merlini JM, Boizot A, Bartoloni L, Santoni F, Karlowicz D, McDonald M, Wu H, Hu Z, Chen G, Ou J, Brasch-Andersen C, Fagerberg CR, Dreyer I, Chun-Hui Tsai A, Slegesky V, McGee RB, Daniels B, Sellars EA, Carpenter LA, Schaefer B, Sacoto MJG, Begtrup A, Schnur RE, Punj S, Wentzensen IM, Rhodes L, Pan Q, Bernier RA, Chen C, Eichler EE, Xia K. NCKAP1 Disruptive Variants Lead to a Neurodevelopmental Disorder with Core Features of Autism. Am J Hum Genet. 2020 11 05; 107(5):963-976.
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Peters CH, Myers ME, Juchno J, Haimbaugh C, Bichraoui H, Du Y, Bankston JR, Walker LA, Proenza C. Isoform-specific regulation of HCN4 channels by a family of endoplasmic reticulum proteins. Proc Natl Acad Sci U S A. 2020 07 28; 117(30):18079-18090.
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Li S, Mecca A, Kim J, Caprara GA, Wagner EL, Du TT, Petrov L, Xu W, Cui R, Rebustini IT, Kachar B, Peng AW, Shin JB. Myosin-VIIa is expressed in multiple isoforms and essential for tensioning the hair cell mechanotransduction complex. Nat Commun. 2020 04 29; 11(1):2066.
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Weskamp K, Tank EM, Miguez R, McBride JP, Gómez NB, White M, Lin Z, Gonzalez CM, Serio A, Sreedharan J, Barmada SJ. Shortened TDP43 isoforms upregulated by neuronal hyperactivity drive TDP43 pathology in ALS. J Clin Invest. 2020 03 02; 130(3):1139-1155.
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Subramanian B, Chun J, Perez-Gill C, Yan P, Stillman IE, Higgs HN, Alper SL, Schlöndorff JS, Pollak MR. FSGS-Causing INF2 Mutation Impairs Cleaved INF2 N-Fragment Functions in Podocytes. J Am Soc Nephrol. 2020 02; 31(2):374-391.
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Timic Stamenic T, Feseha S, Valdez R, Zhao W, Klawitter J, Todorovic SM. Alterations in Oscillatory Behavior of Central Medial Thalamic Neurons Demonstrate a Key Role of CaV3.1 Isoform of T-Channels During Isoflurane-Induced Anesthesia. Cereb Cortex. 2019 12 17; 29(11):4679-4696.
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