Lactams
"Lactams" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Cyclic AMIDES formed from aminocarboxylic acids by the elimination of water. Lactims are the enol forms of lactams.
Descriptor ID |
D007769
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MeSH Number(s) |
D02.065.589 D03.383.411
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Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Lactams".
Below are MeSH descriptors whose meaning is more specific than "Lactams".
This graph shows the total number of publications written about "Lactams" by people in this website by year, and whether "Lactams" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
Year | Major Topic | Minor Topic | Total |
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1995 | 0 | 1 | 1 | 1998 | 1 | 0 | 1 | 2015 | 0 | 1 | 1 | 2016 | 0 | 1 | 1 | 2018 | 0 | 2 | 2 | 2019 | 0 | 2 | 2 | 2020 | 0 | 1 | 1 | 2021 | 0 | 3 | 3 | 2022 | 0 | 1 | 1 | 2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "Lactams" by people in Profiles.
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Liao Y, Remsing Rix LL, Li X, Fang B, Izumi V, Welsh EA, Monastyrskyi A, Haura EB, Koomen JM, Doebele RC, Rix U. Differential network analysis of ROS1 inhibitors reveals lorlatinib polypharmacology through co-targeting PYK2. Cell Chem Biol. 2024 Feb 15; 31(2):284-297.e10.
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Qiao Z, Xu J, Gonzalez R, Miao Y. Effects of Polyethylene Glycol and 8-Aminooctanoic Acid Linkers on Melanoma Uptake of [99mTc]Tc-Tricarbonyl-NOTA-Conjugated Lactam-Cyclized a-MSH Peptides. Bioconjug Chem. 2023 05 17; 34(5):934-940.
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Drilon A, Horan JC, Tangpeerachaikul A, Besse B, Ou SI, Gadgeel SM, Camidge DR, van der Wekken AJ, Nguyen-Phuong L, Acker A, Keddy C, Nicholson KS, Yoda S, Mente S, Sun Y, Soglia JR, Kohl NE, Porter JR, Shair MD, Zhu V, Davare MA, Hata AN, Pelish HE, Lin JJ. NVL-520 Is a Selective, TRK-Sparing, and Brain-Penetrant Inhibitor of ROS1 Fusions and Secondary Resistance Mutations. Cancer Discov. 2023 03 01; 13(3):598-615.
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Albrecht JM, Cooper BR, Waller JD, Presley CL, Pulsipher KJ, Rundle CW, Dellavalle RP. Nirmatrelvir-ritonivir, COVID-19, and possible adverse cutaneous reactions. Dermatol Online J. 2023 Feb 15; 29(1).
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Qiao Z, Xu J, Gonzalez R, Miao Y. Novel 64Cu-Labeled NOTA-Conjugated Lactam-Cyclized Alpha-Melanocyte-Stimulating Hormone Peptides with Enhanced Tumor to Kidney Uptake Ratios. Mol Pharm. 2022 07 04; 19(7):2535-2541.
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Qiao Z, Xu J, Gonzalez R, Miao Y. Novel Al18F-NOTA-Conjugated Lactam-Cyclized a-Melanocyte-Stimulating Hormone Peptides with Enhanced Melanoma Uptake. Bioconjug Chem. 2022 05 18; 33(5):982-990.
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Cywar RM, Rorrer NA, Mayes HB, Maurya AK, Tassone CJ, Beckham GT, Chen EY. Redesigned Hybrid Nylons with Optical Clarity and Chemical Recyclability. J Am Chem Soc. 2022 03 30; 144(12):5366-5376.
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Xu J, Gallazzi F, Fisher DR, Gonzalez R, Miao Y. The Effect of Albumin-Binding Moiety on Tumor Targeting and Biodistribution Properties of 67Ga-Labeled Albumin Binder-Conjugated Alpha-Melanocyte-Stimulating Hormone Peptides. Cancer Biother Radiopharm. 2022 Feb; 37(1):47-55.
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Nguyen DC, Dousa KM, Kurz SG, Brown ST, Drusano G, Holland SM, Kreiswirth BN, Boom WH, Daley CL, Bonomo RA. "One-Two Punch": Synergistic ?-Lactam Combinations for Mycobacterium abscessus and Target Redundancy in the Inhibition of Peptidoglycan Synthesis Enzymes. Clin Infect Dis. 2021 10 20; 73(8):1532-1536.
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Camidge DR. Lorlatinib Should Not be Considered as the Preferred First-Line Option in Patients With Advanced ALK Rearranged NSCLC. J Thorac Oncol. 2021 04; 16(4):528-531.
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