 Tumor Necrosis Factor-alpha
"Tumor Necrosis Factor-alpha" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.
| Descriptor ID |
D014409
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| MeSH Number(s) |
D12.644.276.374.500.800 D12.644.276.374.750.626 D12.776.124.900 D12.776.395.930 D12.776.467.374.500.800 D12.776.467.374.750.626 D23.529.374.500.800 D23.529.374.750.626
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| Concept/Terms |
Tumor Necrosis Factor-alpha- Tumor Necrosis Factor-alpha
- Tumor Necrosis Factor alpha
- Cachectin
- Cachectin-Tumor Necrosis Factor
- Cachectin Tumor Necrosis Factor
- Tumor Necrosis Factor Ligand Superfamily Member 2
- Tumor Necrosis Factor
- TNF Superfamily, Member 2
- TNFalpha
- TNF-alpha
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Below are MeSH descriptors whose meaning is more general than "Tumor Necrosis Factor-alpha".
Below are MeSH descriptors whose meaning is more specific than "Tumor Necrosis Factor-alpha".
This graph shows the total number of publications written about "Tumor Necrosis Factor-alpha" by people in this website by year, and whether "Tumor Necrosis Factor-alpha" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 1993 | 6 | 7 | 13 | | 1994 | 7 | 11 | 18 | | 1995 | 9 | 9 | 18 | | 1996 | 11 | 8 | 19 | | 1997 | 12 | 10 | 22 | | 1998 | 13 | 12 | 25 | | 1999 | 11 | 13 | 24 | | 2000 | 7 | 17 | 24 | | 2001 | 8 | 10 | 18 | | 2002 | 6 | 18 | 24 | | 2003 | 18 | 14 | 32 | | 2004 | 15 | 24 | 39 | | 2005 | 16 | 19 | 35 | | 2006 | 11 | 16 | 27 | | 2007 | 10 | 16 | 26 | | 2008 | 9 | 19 | 28 | | 2009 | 15 | 14 | 29 | | 2010 | 7 | 7 | 14 | | 2011 | 10 | 23 | 33 | | 2012 | 2 | 18 | 20 | | 2013 | 11 | 16 | 27 | | 2014 | 12 | 24 | 36 | | 2015 | 7 | 18 | 25 | | 2016 | 7 | 12 | 19 | | 2017 | 5 | 6 | 11 | | 2018 | 4 | 13 | 17 | | 2019 | 7 | 7 | 14 | | 2020 | 2 | 9 | 11 | | 2021 | 4 | 14 | 18 | | 2022 | 4 | 10 | 14 | | 2023 | 0 | 6 | 6 |
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Below are the most recent publications written about "Tumor Necrosis Factor-alpha" by people in Profiles.
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Ghezzi P, Fantuzzi G, Dinarello CA. Perspective: Daniela Novick, cytokines and their receptors. Front Immunol. 2023; 14:1160651.
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Asken BM, Ljubenkov PA, Staffaroni AM, Casaletto KB, Vandevrede L, Cobigo Y, Rojas-Rodriguez JC, Rankin KP, Kornak J, Heuer H, Shigenaga J, Appleby BS, Bozoki AC, Domoto-Reilly K, Ghoshal N, Huey E, Litvan I, Masdeu JC, Mendez MF, Pascual B, Pressman P, Tartaglia MC, Kremers W, Forsberg LK, Boeve BF, Boxer AL, Rosen HJ, Kramer JH. Plasma inflammation for predicting phenotypic conversion and clinical progression of autosomal dominant frontotemporal lobar degeneration. J Neurol Neurosurg Psychiatry. 2023 07; 94(7):541-549.
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Lisano JK, Kisiolek J, Flores V, Smoak P, Pullen NA, Stewart LK. Chronic cannabis use is associated with altered monocyte phenotype, immune response, and depression in physically active individuals. Can J Physiol Pharmacol. 2023 Jun 01; 101(6):316-326.
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Agraval H, Crue T, Schaunaman N, Numata M, Day BJ, Chu HW. Electronic Cigarette Exposure Increases the Severity of Influenza a Virus Infection via TRAIL Dysregulation in Human Precision-Cut Lung Slices. Int J Mol Sci. 2023 Feb 21; 24(5).
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Holmer AK, Luo J, Russ KB, Park S, Yang JY, Ertem F, Dueker J, Nguyen V, Hong S, Zenger C, Axelrad JE, Sofia A, Petrov JC, Al-Bawardy B, Fudman DI, Llano E, Dailey J, Jangi S, Khakoo N, Damas OM, Barnes EL, Scott FI, Ungaro RC, Singh S. Comparative Safety of Biologic Agents in Patients With Inflammatory Bowel Disease With Active or Recent Malignancy: A Multi-Center Cohort Study. Clin Gastroenterol Hepatol. 2023 06; 21(6):1598-1606.e5.
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Sagel SD, Kupfer O, Wagner BD, Davis SD, Dell SD, Ferkol TW, Hoppe JE, Rosenfeld M, Sullivan KM, Tiddens HAWM, Knowles MR, Leigh MW. Airway Inflammation in Children with Primary Ciliary Dyskinesia. Ann Am Thorac Soc. 2023 01; 20(1):67-74.
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Ni?o KE, Pietras EM. TNF Receptors Choose HSC Fate in Supporting Dnmt3a-Mutant Clonal Hematopoiesis. Cancer Discov. 2022 Dec 02; 12(12):2724-2726.
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Schafer JB, Lucas ED, Dzieciatkowska M, Forward T, Tamburini BAJ. Programmed death ligand 1 intracellular interactions with STAT3 and focal adhesion protein Paxillin facilitate lymphatic endothelial cell remodeling. J Biol Chem. 2022 12; 298(12):102694.
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Renton WD, Jung J, Palestine AG. Tumor necrosis factor (TNF) inhibitors for juvenile idiopathic arthritis-associated uveitis. Cochrane Database Syst Rev. 2022 10 14; 10:CD013818.
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Kahn D, Macias E, Zarini S, Garfield A, Zemski Berry K, MacLean P, Gerszten RE, Libby A, Solt C, Schoen J, Bergman BC. Exploring Visceral and Subcutaneous Adipose Tissue Secretomes in Human Obesity: Implications for Metabolic Disease. Endocrinology. 2022 10 11; 163(11).
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