 Tumor Necrosis Factor-alpha
"Tumor Necrosis Factor-alpha" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.
| Descriptor ID |
D014409
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| MeSH Number(s) |
D12.644.276.374.500.800 D12.644.276.374.750.626 D12.776.124.900 D12.776.395.930 D12.776.467.374.500.800 D12.776.467.374.750.626 D23.529.374.500.800 D23.529.374.750.626
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| Concept/Terms |
Tumor Necrosis Factor-alpha- Tumor Necrosis Factor-alpha
- Tumor Necrosis Factor alpha
- Cachectin
- Cachectin-Tumor Necrosis Factor
- Cachectin Tumor Necrosis Factor
- Tumor Necrosis Factor Ligand Superfamily Member 2
- Tumor Necrosis Factor
- TNF Superfamily, Member 2
- TNFalpha
- TNF-alpha
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Below are MeSH descriptors whose meaning is more general than "Tumor Necrosis Factor-alpha".
Below are MeSH descriptors whose meaning is more specific than "Tumor Necrosis Factor-alpha".
This graph shows the total number of publications written about "Tumor Necrosis Factor-alpha" by people in this website by year, and whether "Tumor Necrosis Factor-alpha" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 1996 | 13 | 7 | 20 | | 1997 | 17 | 14 | 31 | | 1998 | 14 | 15 | 29 | | 1999 | 14 | 14 | 28 | | 2000 | 8 | 19 | 27 | | 2001 | 16 | 17 | 33 | | 2002 | 8 | 27 | 35 | | 2003 | 18 | 17 | 35 | | 2004 | 15 | 25 | 40 | | 2005 | 15 | 21 | 36 | | 2006 | 12 | 20 | 32 | | 2007 | 11 | 18 | 29 | | 2008 | 10 | 18 | 28 | | 2009 | 16 | 19 | 35 | | 2010 | 7 | 7 | 14 | | 2011 | 11 | 19 | 30 | | 2012 | 5 | 16 | 21 | | 2013 | 10 | 20 | 30 | | 2014 | 13 | 28 | 41 | | 2015 | 7 | 21 | 28 | | 2016 | 8 | 15 | 23 | | 2017 | 7 | 10 | 17 | | 2018 | 4 | 15 | 19 | | 2019 | 8 | 9 | 17 | | 2020 | 5 | 17 | 22 | | 2021 | 4 | 17 | 21 | | 2022 | 6 | 15 | 21 | | 2023 | 0 | 11 | 11 | | 2024 | 4 | 11 | 15 | | 2025 | 4 | 4 | 8 | | 2026 | 1 | 2 | 3 |
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Below are the most recent publications written about "Tumor Necrosis Factor-alpha" by people in Profiles.
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Lee J, Chung YM, Silver DJ, Hao Y, Harwood DSL, Ealy A, Serapiglia AM, Curtin L, Benedetti JR, Ballard CAP, Lapsley K, Alvarez-Vazquez A, Goldberg J, Li C, Kaur S, Neal R, Wang SZ, Kay KE, Volovetz J, Hong ES, Fodor R, Jarmula J, Nicosia M, Rubin JB, Swanson KR, Ostrom QT, Panicker N, Kristensen BW, Berens M, Sharifi N, Lathia JD. Androgen loss accelerates brain tumour growth via HPA axis activation. Nature. 2026 May; 653(8116):1184-1195.
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Moran M, Salmon K, Dhaliwal SK, Dabelea D, Perng W. Associations of Maternal Prenatal Inflammation With Child Adiposity: The Healthy Start Study. Pediatr Obes. 2026 Feb; 21(2):e70088.
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Shaikh FS, Shanta MA, Singh AK, Daniels AM, Khuder SA, Thiele GM, Reed GW, Kremer JM, Pappas DA, Curtis JR, O'Dell JR, Ouseph MM, Fox DA, Ahmed S. TWEAK receptor (Fn14) exacerbates TNF-a-induced inflammation in rheumatoid arthritis synovial fibroblasts and influences response to anti-TNF-a therapy. Cell Mol Immunol. 2026 Mar; 23(3):315-328.
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Necker-Brown A, Mostafa MM, Georgescu A, Thorne AJ, Chandramohan P, Kooi C, Kalyanaraman K, Gao A, Bansal A, Sasse SK, Gerber AN, Leigh R, Newton R. Inflammatory cytokines promote interferon regulatory factor (IRF) transcriptional activity in human pulmonary epithelial cells through the induction of IRF1 by nuclear factor-?B. PLoS One. 2025; 20(12):e0329244.
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Shahin MM, Gorell ES, Iqneibi M, Sun Q, Brunner HI, Hellmann J, Marathe KS. Characterization of TNF-Alpha Inhibitor Induced Paradoxical Psoriasiform Dermatitis at a Single Center via Retrospective Chart Review. Pediatr Dermatol. 2026 Jan-Feb; 43(1):84-87.
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Sripada A, Verma D, Varma R, Sirohi K, Kwiat C, Pathria M, Verma M, Sahu A, Guntur V, Manka L, Vestal B, Moore C, Martin RJ, Gorska MM, Cambier J, Getahun A, Alam R. Allergens abrogate antiinflammatory DNA effects and unmask macrophage-driven neutrophilic asthma via ILC2/STING/TNF-a signaling. J Clin Invest. 2025 Aug 15; 135(16).
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Rojas-Sanchez G, Calzada-Martinez J, McMahon B, Petrey AC, Dveksler G, Espino-Solis GP, Esparza O, Hernandez G, Le D, Wartchow EP, Jones K, Ting LH, Jankowski C, Kelher MR, Manco-Johnson M, Feser ML, Deane KD, Nemkov T, D'Alessandro A, Thorburn A, Maycotte P, López JA, Davizon-Castillo P. TNF-a impairs platelet function by inhibiting autophagy and disrupting metabolism via syntaxin 17 downregulation. J Clin Invest. 2025 Aug 01; 135(15).
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Larson EA, Smith LE, Perng W, Switkowski KM, Rifas-Shiman SL, Oken E. The Interplay of Dietary Choline and Methyl Donors in Modulating Maternal Inflammation: Insights from Project Viva. J Nutr. 2025 Jun; 155(6):1999-2005.
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Lee GY, Schaunaman N, Nouri HR, Kraft M, Chu HW. Comprehensive single-cell RNA-sequencing study of Tollip deficiency effect in IL-13-stimulated human airway epithelial cells. BMC Res Notes. 2025 Apr 23; 18(1):194.
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Chilukuri A, Kim M, Mitra T, Gubatan JM, Urrete J, Saxon LD, Ablack A, Mikulski Z, Dobaczewska K, Shen Z, Keir M, Yi T, Kaur P, Oliveira P, Murillo-Saich J, Chang EY, Steiner CA, Jedlicka P, Guma M, Rivera-Nieves J. A Similar Mutation in the AAUU-Rich Elements of the Mouse TNF Gene Results in a Distinct Ileocolitic Phenotype: A New Strain of TNF-Overexpressing Mice. Inflamm Bowel Dis. 2025 Apr 10; 31(4):1067-1081.
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