 Secretory Leukocyte Peptidase Inhibitor
"Secretory Leukocyte Peptidase Inhibitor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A proteinase inhibitor found in various BODILY SECRETIONS that coat mucosal surfaces such as SEMINAL PLASMA; CERVICAL MUCUS; and bronchial secretions. It plays a role in protecting epithelial tissues from LEUKOCYTE-derived serine proteases such as NEUTROPHIL ELASTASE.
| Descriptor ID |
D053481
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| MeSH Number(s) |
D12.644.822.500 D12.776.645.500
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| Concept/Terms |
Secretory Leukocyte Peptidase Inhibitor- Secretory Leukocyte Peptidase Inhibitor
- Antileukoprotease
- Bronchial Mucus Elastase Inhibitor
- Seminal Proteinase Inhibitor
- Mucus Protease Inhibitor
- Protease Inhibitor, Mucus
- Mucus Proteinase Inhibitor
- Proteinase Inhibitor, Mucus
- Secretory Leukocyte-Protease Inhibitor
- Secretory Leukocyte Protease Inhibitor
- Secretory Leukoprotease Inhibitor
- Leukocyte Peptidase Inhibitor, Secretory
- Elastase Inhibitor, Mucus
- Mucus Elastase Inhibitor
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Below are MeSH descriptors whose meaning is more general than "Secretory Leukocyte Peptidase Inhibitor".
Below are MeSH descriptors whose meaning is more specific than "Secretory Leukocyte Peptidase Inhibitor".
This graph shows the total number of publications written about "Secretory Leukocyte Peptidase Inhibitor" by people in this website by year, and whether "Secretory Leukocyte Peptidase Inhibitor" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 2 | 2 | | 2001 | 0 | 1 | 1 | | 2009 | 1 | 0 | 1 | | 2014 | 0 | 1 | 1 | | 2015 | 1 | 0 | 1 |
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Below are the most recent publications written about "Secretory Leukocyte Peptidase Inhibitor" by people in Profiles.
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Raundhal M, Morse C, Khare A, Oriss TB, Milosevic J, Trudeau J, Huff R, Pilewski J, Holguin F, Kolls J, Wenzel S, Ray P, Ray A. High IFN-? and low SLPI mark severe asthma in mice and humans. J Clin Invest. 2015 Aug 03; 125(8):3037-50.
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Sch?fer M, Willrodt AH, Kurinna S, Link AS, Farwanah H, Geusau A, Gruber F, Sorg O, Huebner AJ, Roop DR, Sandhoff K, Saurat JH, Tschachler E, Schneider MR, Langbein L, Bloch W, Beer HD, Werner S. Activation of Nrf2 in keratinocytes causes chloracne (MADISH)-like skin disease in mice. EMBO Mol Med. 2014 04; 6(4):442-57.
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Sagel SD, Sontag MK, Accurso FJ. Relationship between antimicrobial proteins and airway inflammation and infection in cystic fibrosis. Pediatr Pulmonol. 2009 Apr; 44(4):402-9.
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Pillay K, Coutsoudis A, Agadzi-Naqvi AK, Kuhn L, Coovadia HM, Janoff EN. Secretory leukocyte protease inhibitor in vaginal fluids and perinatal human immunodeficiency virus type 1 transmission. J Infect Dis. 2001 Feb 15; 183(4):653-6.
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Grobmyer SR, Barie PS, Nathan CF, Fuortes M, Lin E, Lowry SF, Wright CD, Weyant MJ, Hydo L, Reeves F, Shiloh MU, Ding A. Secretory leukocyte protease inhibitor, an inhibitor of neutrophil activation, is elevated in serum in human sepsis and experimental endotoxemia. Crit Care Med. 2000 May; 28(5):1276-82.
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Wahl SM, McNeely TB, Janoff EN, Shugars D, Worley P, Tucker C, Orenstein JM. Secretory leukocyte protease inhibitor (SLPI) in mucosal fluids inhibits HIV-I. Oral Dis. 1997 May; 3 Suppl 1:S64-9.
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Wahl SM, Worley P, Jin W, McNeely TB, Eisenberg S, Fasching C, Orenstein JM, Janoff EN. Anatomic dissociation between HIV-1 and its endogenous inhibitor in mucosal tissues. Am J Pathol. 1997 Apr; 150(4):1275-84.
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