 Baclofen
"Baclofen" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A GAMMA-AMINOBUTYRIC ACID derivative that is a specific agonist of GABA-B RECEPTORS. It is used in the treatment of MUSCLE SPASTICITY, especially that due to SPINAL CORD INJURIES. Its therapeutic effects result from actions at spinal and supraspinal sites, generally the reduction of excitatory transmission.
| Descriptor ID |
D001418
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| MeSH Number(s) |
D02.241.081.114.500.350.100
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| Concept/Terms |
Baclofen- Baclofen
- Baclophen
- PCP-GABA
- beta-(Aminomethyl)-4-chlorobenzenepropanoic Acid
- Chlorophenyl GABA
- GABA, Chlorophenyl
- beta-(p-Chlorophenyl)-gamma-aminobutyric Acid
Ba-34,647- Ba-34,647
- Ba34,647
- Ba-34647
- Ba34647
- CIBA-34,647-BA
- CIBA34,647BA
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Below are MeSH descriptors whose meaning is more general than "Baclofen".
Below are MeSH descriptors whose meaning is more specific than "Baclofen".
This graph shows the total number of publications written about "Baclofen" by people in this website by year, and whether "Baclofen" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 | | 2002 | 0 | 1 | 1 | | 2003 | 2 | 0 | 2 | | 2009 | 1 | 0 | 1 | | 2010 | 0 | 1 | 1 | | 2014 | 1 | 0 | 1 | | 2021 | 1 | 0 | 1 | | 2022 | 0 | 1 | 1 | | 2023 | 1 | 0 | 1 |
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Below are the most recent publications written about "Baclofen" by people in Profiles.
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Killam-Worrall L, Brand R, Castro JR, Patel DS, Huynh K, Lindley B, Torres BP. Baclofen and Tizanidine Adverse Effects Observed Among Community-Dwelling Adults Above the Age of 50 Years: A Systematic Review. Ann Pharmacother. 2024 May; 58(5):523-532.
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Xu AL, Marrache M, Hardesty CK, Groves ML, Erickson MA, Murphy RF, Thompson GH, Sponseller PD. Baclofen Pump Use: Complications After Growth-friendly Instrumentation for Early-onset Scoliosis. J Pediatr Orthop. 2022 Feb 01; 42(2):77-82.
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Shao L, Elujoba-Bridenstine A, Zink KE, Sanchez LM, Cox BJ, Pollok KE, Sinn AL, Bailey BJ, Sims EC, Cooper SH, Broxmeyer HE, Pajcini KV, Tamplin OJ. The neurotransmitter receptor Gabbr1 regulates proliferation and function of hematopoietic stem and progenitor cells. Blood. 2021 02 11; 137(6):775-787.
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Mohon RT, Sawyer K, Pickett K, Bothwell S, Brinton JT, Sobremonte-King M, DelRosso LM. Sleep-related breathing disorders associated with intrathecal baclofen therapy to treat patients with cerebral palsy: A cohort study and discussion. NeuroRehabilitation. 2021; 48(4):481-491.
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Hillman L, Yadlapati R, Thuluvath AJ, Berendsen MA, Pandolfino JE. A review of medical therapy for proton pump inhibitor nonresponsive gastroesophageal reflux disease. Dis Esophagus. 2017 Sep 01; 30(9):1-15.
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Kapil V, Green JL, Le Lait MC, Wood DM, Dargan PI. Misuse of the ?-aminobutyric acid analogues baclofen, gabapentin and pregabalin in the UK. Br J Clin Pharmacol. 2014 Jul; 78(1):190-1.
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McClure-Begley TD, Grady SR, Marks MJ, Collins AC, Stitzel JA. Presynaptic GABAB autoreceptor regulation of nicotinic acetylcholine receptor mediated [(3)H]-GABA release from mouse synaptosomes. Biochem Pharmacol. 2014 Sep 01; 91(1):87-96.
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Varhabhatla NC, Zuo Z. Rising complication rates after intrathecal catheter and pump placement in the pediatric population: analysis of national data between 1997 and 2006. Pain Physician. 2012 Jan-Feb; 15(1):65-74.
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Oleson EB, Richardson JM, Roberts DC. A novel IV cocaine self-administration procedure in rats: differential effects of dopamine, serotonin, and GABA drug pre-treatments on cocaine consumption and maximal price paid. Psychopharmacology (Berl). 2011 Mar; 214(2):567-77.
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Kahn R, Biswas K, Childress AR, Shoptaw S, Fudala PJ, Gorgon L, Montoya I, Collins J, McSherry F, Li SH, Chiang N, Alathari H, Watson D, Liberto J, Beresford T, Stock C, Wallace C, Gruber V, Elkashef A. Multi-center trial of baclofen for abstinence initiation in severe cocaine-dependent individuals. Drug Alcohol Depend. 2009 Jul 01; 103(1-2):59-64.
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