 tau Proteins
"tau Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Microtubule-associated proteins that are mainly expressed in neurons. Tau proteins constitute several isoforms and play an important role in the assembly of tubulin monomers into microtubules and in maintaining the cytoskeleton and axonal transport. Aggregation of specific sets of tau proteins in filamentous inclusions is the common feature of intraneuronal and glial fibrillar lesions (NEUROFIBRILLARY TANGLES; NEUROPIL THREADS) in numerous neurodegenerative disorders (ALZHEIMER DISEASE; TAUOPATHIES).
| Descriptor ID |
D016875
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| MeSH Number(s) |
D12.776.220.600.450.510 D12.776.631.560.510
|
| Concept/Terms |
tau Proteins- tau Proteins
- Proteins, tau
- tau Protein
- Protein, tau
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Below are MeSH descriptors whose meaning is more general than "tau Proteins".
Below are MeSH descriptors whose meaning is more specific than "tau Proteins".
This graph shows the total number of publications written about "tau Proteins" by people in this website by year, and whether "tau Proteins" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1993 | 1 | 0 | 1 | | 1995 | 0 | 1 | 1 | | 2000 | 3 | 0 | 3 | | 2004 | 3 | 0 | 3 | | 2005 | 0 | 1 | 1 | | 2006 | 1 | 1 | 2 | | 2007 | 0 | 1 | 1 | | 2008 | 1 | 1 | 2 | | 2009 | 2 | 0 | 2 | | 2010 | 1 | 2 | 3 | | 2012 | 3 | 1 | 4 | | 2013 | 0 | 3 | 3 | | 2014 | 2 | 1 | 3 | | 2015 | 0 | 1 | 1 | | 2016 | 3 | 5 | 8 | | 2017 | 4 | 2 | 6 | | 2018 | 3 | 0 | 3 | | 2019 | 7 | 2 | 9 | | 2020 | 2 | 1 | 3 | | 2021 | 0 | 1 | 1 | | 2022 | 0 | 2 | 2 |
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Below are the most recent publications written about "tau Proteins" by people in Profiles.
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Johnson NR. Tau acetylation reduces its autophagic degradation and is a targetable pathway for human tauopathies. Bioessays. 2022 06; 44(6):e2200062.
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Winder Z, Sudduth TL, Anderson S, Patel E, Neltner J, Martin BJ, Snyder KE, Abner EL, Jicha GA, Nelson PT, Wilcock DM. Examining the association between blood-based biomarkers and human post mortem neuropathology in the University of Kentucky Alzheimer's Disease Research Center autopsy cohort. Alzheimers Dement. 2023 01; 19(1):67-78.
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Jevtovic-Todorovic V. Testosterone: much more for the brain than a sex hormone. Br J Anaesth. 2022 03; 128(3):411-413.
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Barkhof F, Pressman PS. Early Detection of Incipient Alzheimer Pathology: Time Is of the Essence. Neurology. 2021 04 06; 96(14):647-648.
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Lemoine L, Ledreux A, Mufson EJ, Perez SE, Simic G, Doran E, Lott I, Carroll S, Bharani K, Thomas S, Gilmore A, Hamlett ED, Nordberg A, Granholm AC. Regional binding of tau and amyloid PET tracers in Down syndrome autopsy brain tissue. Mol Neurodegener. 2020 11 23; 15(1):68.
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Majewski J, Jones EM, Vander Zanden CM, Biernat J, Mandelkow E, Chi EY. Lipid membrane templated misfolding and self-assembly of intrinsically disordered tau protein. Sci Rep. 2020 08 07; 10(1):13324.
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Elman JA, Panizzon MS, Gustavson DE, Franz CE, Sanderson-Cimino ME, Lyons MJ, Kremen WS. Amyloid-? Positivity Predicts Cognitive Decline but Cognition Predicts Progression to Amyloid-? Positivity. Biol Psychiatry. 2020 05 01; 87(9):819-828.
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Wu PC, Fann MJ, Tran TT, Chen SC, Devina T, Cheng IH, Lien CC, Kao LS, Wang SJ, Fuh JL, Tzeng TT, Huang CY, Shiao YJ, Wong YH. Assessing the therapeutic potential of Graptopetalum paraguayense on Alzheimer's disease using patient iPSC-derived neurons. Sci Rep. 2019 12 17; 9(1):19301.
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Bharani KL, Ledreux A, Gilmore A, Carroll SL, Granholm AC. Serum pro-BDNF levels correlate with phospho-tau staining in Alzheimer's disease. Neurobiol Aging. 2020 03; 87:49-59.
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Vander Zanden CM, Chi EY. Passive Immunotherapies Targeting Amyloid Beta and Tau Oligomers in Alzheimer's Disease. J Pharm Sci. 2020 01; 109(1):68-73.
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