 Placental Lactogen
"Placental Lactogen" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A polypeptide hormone of approximately 25 kDa that is produced by the SYNCYTIOTROPHOBLASTS of the PLACENTA, also known as chorionic somatomammotropin. It has both GROWTH HORMONE and PROLACTIN activities on growth, lactation, and luteal steroid production. In women, placental lactogen secretion begins soon after implantation and increases to 1 g or more a day in late pregnancy. Placental lactogen is also an insulin antagonist.
| Descriptor ID |
D010928
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| MeSH Number(s) |
D06.472.699.649.692 D12.644.548.726.692 D12.776.780.650
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| Concept/Terms |
Placental Lactogen- Placental Lactogen
- Lactogen, Placental
- Choriomammotropin
- Lactogen Hormone, Placental
- Mammotropic Hormone, Placental
- Placental Mammotropic Hormone
- Pregnancy-Associated Plasma Protein D
- Pregnancy Associated Plasma Protein D
- Placental Luteotropin
- Luteotropin, Placental
- Somatomammotropin, Chorionic
- Chorionic Somatomammotropin
- Choriomammotrophin
- PAPP-D
Human Placental Lactogen- Human Placental Lactogen
- Placental Lactogen, Human
- HCS (Human Chorionic Somatomammotropin)
- HPL (Human Placental Lactogen)
- Chorionic Somatomammotropin, Human
- Human Chorionic Somatomammotropin
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Below are MeSH descriptors whose meaning is more general than "Placental Lactogen".
Below are MeSH descriptors whose meaning is more specific than "Placental Lactogen".
This graph shows the total number of publications written about "Placental Lactogen" by people in this website by year, and whether "Placental Lactogen" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1990 | 1 | 0 | 1 | | 1991 | 1 | 0 | 1 | | 1992 | 0 | 1 | 1 | | 1999 | 0 | 1 | 1 | | 2018 | 1 | 0 | 1 |
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Below are the most recent publications written about "Placental Lactogen" by people in Profiles.
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Whittaker PG, Schreiber CA, Sammel MD. Gestational hormone trajectories and early pregnancy failure: a reassessment. Reprod Biol Endocrinol. 2018 Oct 11; 16(1):95.
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Regnault TR, Orbus RJ, Battaglia FC, Wilkening RB, Anthony RV. Altered arterial concentrations of placental hormones during maximal placental growth in a model of placental insufficiency. J Endocrinol. 1999 Sep; 162(3):433-42.
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Cramer SD, Wong L, Kensinger RS, Ogren L, Talamantes F. Regulation of the hepatic growth hormone receptor and serum growth hormone-binding protein during pregnancy in the mouse: effects of litter size. Endocrinology. 1992 Dec; 131(6):2914-20.
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Zeitler P, Wu YQ, Handwerger S. Melittin stimulates phosphoinositide hydrolysis and placental lactogen release: arachidonic acid as a link between phospholipase A2 and phospholipase C signal-transduction pathways. Life Sci. 1991; 48(21):2089-95.
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Bagga R, Vasishta K, Majumdar S, Garg SK. Correlation between human placental lactogen levels and glucose metabolism in pregnant women with intrauterine growth retardation. Aust N Z J Obstet Gynaecol. 1990 Nov; 30(4):310-3.
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Harman I, Zeitler P, Ganong B, Bell RM, Handwerger S. Sn-1,2-diacylglycerols and phorbol esters stimulate the synthesis and release of human placental lactogen from placental cells: a role for protein kinase C. Endocrinology. 1986 Sep; 119(3):1239-44.
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Zeitler P, Murphy E, Handwerger S. Arachidonic acid stimulates 45calcium efflux and hPL release in isolated trophoblast cells. Life Sci. 1986 Jan 13; 38(2):99-107.
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Zeitler P, Handwerger S. Arachidonic acid stimulates phosphoinositide hydrolysis and human placental lactogen release in an enriched fraction of placental cells. Mol Pharmacol. 1985 Dec; 28(6):549-54.
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Zeitler P, Markoff E, Handwerger S. Characterization of the synthesis and release of human placental lactogen and human chorionic gonadotropin by an enriched population of dispersed placental cells. J Clin Endocrinol Metab. 1983 Oct; 57(4):812-8.
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Handwerger S, Barrett J, Barry S, Markoff E, Zeitler P, Cwikel B, Siegel M. Stimulation of human placental lactogen release by arachidonic acid. Mol Pharmacol. 1981 Nov; 20(3):609-13.
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