 Acetylcysteine
"Acetylcysteine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The N-acetyl derivative of CYSTEINE. It is used as a mucolytic agent to reduce the viscosity of mucous secretions. It has also been shown to have antiviral effects in patients with HIV due to inhibition of viral stimulation by reactive oxygen intermediates.
| Descriptor ID |
D000111
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| MeSH Number(s) |
D02.886.030.230.259 D12.125.166.230.259
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| Concept/Terms |
Acetylcysteine- Acetylcysteine
- N-Acetyl-L-cysteine
- N Acetyl L cysteine
- N-Acetylcysteine
- N Acetylcysteine
- Mercapturic Acid
- Acid, Mercapturic
Acetylcysteine Sodium- Acetylcysteine Sodium
- Sodium, Acetylcysteine
- Acetylcysteine, Monosodium Salt
- Monosodium Salt Acetylcysteine
Fluprowit- Fluprowit
- Optipect Hustengetränk
- Hustengetränk, Optipect
- Muco Sanigen
- Sanigen, Muco
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Below are MeSH descriptors whose meaning is more general than "Acetylcysteine".
Below are MeSH descriptors whose meaning is more specific than "Acetylcysteine".
This graph shows the total number of publications written about "Acetylcysteine" by people in this website by year, and whether "Acetylcysteine" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1991 | 1 | 0 | 1 | | 1993 | 1 | 0 | 1 | | 1995 | 0 | 1 | 1 | | 2000 | 0 | 2 | 2 | | 2001 | 1 | 0 | 1 | | 2002 | 1 | 1 | 2 | | 2003 | 1 | 0 | 1 | | 2004 | 2 | 2 | 4 | | 2005 | 2 | 4 | 6 | | 2006 | 3 | 2 | 5 | | 2007 | 5 | 3 | 8 | | 2008 | 2 | 2 | 4 | | 2009 | 2 | 0 | 2 | | 2010 | 6 | 7 | 13 | | 2011 | 4 | 2 | 6 | | 2012 | 2 | 5 | 7 | | 2013 | 4 | 1 | 5 | | 2014 | 4 | 1 | 5 | | 2015 | 1 | 1 | 2 | | 2016 | 4 | 1 | 5 | | 2017 | 1 | 1 | 2 | | 2018 | 1 | 0 | 1 | | 2019 | 1 | 3 | 4 |
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Below are the most recent publications written about "Acetylcysteine" by people in Profiles.
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Miller DR, Ingersoll MA, Chatterjee A, Baker B, Shrishrimal S, Kosmacek EA, Zhu Y, Cheng PW, Oberley-Deegan RE, Lin MF. p66Shc protein through a redox mechanism enhances the progression of prostate cancer cells towards castration-resistance. Free Radic Biol Med. 2019 08 01; 139:24-34.
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Hoyte C, Dart RC. Transition to two-bag intravenous acetylcysteine for acetaminophen overdose: a poison center's experience. Clin Toxicol (Phila). 2019 03; 57(3):217-218.
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Mutsaers A, Green JP, Sivilotti MLA, Yarema MC, Tucker D, Johnson DW, Spyker DA, Rumack BH. Changing nomogram risk zone classification with serial testing after acute acetaminophen overdose: a retrospective database analysis. Clin Toxicol (Phila). 2019 06; 57(6):380-386.
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Bagati A, Moparthy S, Fink EE, Bianchi-Smiraglia A, Yun DH, Kolesnikova M, Udartseva OO, Wolff DW, Roll MV, Lipchick BC, Han Z, Kozlova NI, Jowdy P, Berman AE, Box NF, Rodriguez C, Bshara W, Kandel ES, Soengas MS, Paragh G, Nikiforov MA. KLF9-dependent ROS regulate melanoma progression in stage-specific manner. Oncogene. 2019 05; 38(19):3585-3597.
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Yarema M, Chopra P, Sivilotti MLA, Johnson D, Nettel-Aguirre A, Bailey B, Victorino C, Gosselin S, Purssell R, Thompson M, Spyker D, Rumack B. Anaphylactoid Reactions to Intravenous N-Acetylcysteine during Treatment for Acetaminophen Poisoning. J Med Toxicol. 2018 Jun; 14(2):120-127.
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Sharma S, Gralla J, Ordonez JG, Hurtado ME, Swenson ER, Schoene RB, Kelly JP, Callacondo D, Rivard C, Roncal-Jimenez C, Sirota J, Fuquay R, Jackson BP, Swenson KE, Johnson RJ, Hurtado A, Escudero E. Acetazolamide and N-acetylcysteine in the treatment of chronic mountain sickness (Monge's disease). Respir Physiol Neurobiol. 2017 12; 246:1-8.
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Yarema MC, Sivilotti MLA, Nettel-Aguirre A, Rumack BH. Reply to: Limitations of the evidence supporting use of undetectable acetaminophen levels obtained <4?hours post-ingestion to rule out toxicity. Clin Toxicol (Phila). 2017 06; 55(5):367.
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Yarema MC, Green JP, Sivilotti ML, Johnson DW, Nettel-Aguirre A, Victorino C, Spyker DA, Rumack BH. Can a serum acetaminophen concentration obtained less than 4 hours post-ingestion determine which patients do not require treatment with acetylcysteine? Clin Toxicol (Phila). 2017 Feb; 55(2):102-108.
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Bauer AK, Fitzgerald M, Ladzinski AT, Lenhart Sherman S, Maddock BH, Norr ZM, Miller RR. Dual behavior of N-acetylcysteine during ethanol-induced oxidative stress in embryonic chick brains. Nutr Neurosci. 2017 Oct; 20(8):478-488.
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Lucyk SN, Yarema MC, Sivilotti ML, Johnson DW, Nettel-Aguirre A, Victorino C, Bailey B, Dart RC, Heard K, Spyker DA, Rumack BH. Outcomes of Patients With Premature Discontinuation of the 21-h Intravenous N-Acetylcysteine Protocol After Acute Acetaminophen Overdose. J Emerg Med. 2016 Apr; 50(4):629-37.
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