 Antigenic Variation
"Antigenic Variation" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Change in the surface ANTIGEN of a microorganism. There are two different types. One is a phenomenon, especially associated with INFLUENZA VIRUSES, where they undergo spontaneous variation both as slow antigenic drift and sudden emergence of new strains (antigenic shift). The second type is when certain PARASITES, especially trypanosomes, PLASMODIUM, and BORRELIA, survive the immune response of the host by changing the surface coat (antigen switching). (From Herbert et al., The Dictionary of Immunology, 4th ed)
| Descriptor ID |
D000940
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| MeSH Number(s) |
G05.365.073 G12.500.249
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| Concept/Terms |
Antigenic Variation- Antigenic Variation
- Antigenic Variability
- Variability, Antigenic
- Variation, Antigenic
- Antigen Variation
- Variation, Antigen
Antigen Switching- Antigen Switching
- Switching, Antigen
- Switching, Antigenic
- Antigenic Switching
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Below are MeSH descriptors whose meaning is more general than "Antigenic Variation".
Below are MeSH descriptors whose meaning is more specific than "Antigenic Variation".
This graph shows the total number of publications written about "Antigenic Variation" by people in this website by year, and whether "Antigenic Variation" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 | | 1997 | 1 | 0 | 1 | | 2004 | 1 | 2 | 3 | | 2009 | 0 | 1 | 1 | | 2011 | 1 | 0 | 1 | | 2018 | 0 | 1 | 1 |
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Below are the most recent publications written about "Antigenic Variation" by people in Profiles.
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Guthmiller JJ, Wilson PC. Harnessing immune history to combat influenza viruses. Curr Opin Immunol. 2018 08; 53:187-195.
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Kemmler CB, Clambey ET, Kedl RM, Slansky JE. Elevated tumor-associated antigen expression suppresses variant peptide vaccine responses. J Immunol. 2011 Nov 01; 187(9):4431-9.
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Zimmer SM, Burke DS. Historical perspective--Emergence of influenza A (H1N1) viruses. N Engl J Med. 2009 Jul 16; 361(3):279-85.
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McKinney DM, Skvoretz R, Livingston BD, Wilson CC, Anders M, Chesnut RW, Sette A, Essex M, Novitsky V, Newman MJ. Recognition of variant HIV-1 epitopes from diverse viral subtypes by vaccine-induced CTL. J Immunol. 2004 Aug 01; 173(3):1941-50.
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Ott PA, Dittrich MT, Herzog BA, Guerkov R, Gottlieb PA, Putnam AL, Durinovic-Bello I, Boehm BO, Tary-Lehmann M, Lehmann PV. T cells recognize multiple GAD65 and proinsulin epitopes in human type 1 diabetes, suggesting determinant spreading. J Clin Immunol. 2004 Jul; 24(4):327-39.
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Voskuil MI, Schnappinger D, Rutherford R, Liu Y, Schoolnik GK. Regulation of the Mycobacterium tuberculosis PE/PPE genes. Tuberculosis (Edinb). 2004; 84(3-4):256-62.
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Hafalla JC, Santiago ML, Pasay MC, Ramirez BL, Gozar MM, Saul A, Kaslow DC. Minimal variation in the Pfs28 ookinete antigen from Philippine field isolates of Plasmodium falciparum. Mol Biochem Parasitol. 1997 Jul; 87(1):97-9.
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Hurley CK, Steiner N, Hoyer RJ, Menchaca E, Mitton W, Simonis T, Hartzman RJ, Johnson AH, Ng J. Novel HLA-B alleles, B*8201, B*3515 and B*5106, add to the complexity of serologic identification of HLA types. Tissue Antigens. 1996 Mar; 47(3):179-87.
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