 Isoprostanes
"Isoprostanes" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A series of prostaglandin-like compounds that are produced by the attack of free-radical species on unsaturated fatty acids, especially ARACHIDONIC ACID, of cellular MEMBRANES. Once cleaved from the lipid membrane by the action of phospholipases they can circulate into various bodily fluids and eventually be excreted. Although these compounds resemble enzymatically synthesized prostaglandins their stereoisometric arrangement is usually different than the "naturally occurring" compounds.
| Descriptor ID |
D028421
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| MeSH Number(s) |
D10.251.355.255.100.375 D10.251.355.310.166.775 D10.251.355.411
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Isoprostanes".
Below are MeSH descriptors whose meaning is more specific than "Isoprostanes".
This graph shows the total number of publications written about "Isoprostanes" by people in this website by year, and whether "Isoprostanes" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 0 | 1 | 1 | | 2007 | 1 | 0 | 1 | | 2008 | 0 | 1 | 1 |
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Below are the most recent publications written about "Isoprostanes" by people in Profiles.
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S?nchez-Illana ?, Shah V, Pi?eiro-Ramos JD, Di Fiore JM, Quint?s G, Raffay TM, MacFarlane PM, Martin RJ, Kuligowski J. Adrenic acid non-enzymatic peroxidation products in biofluids of moderate preterm infants. Free Radic Biol Med. 2019 10; 142:107-112.
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Bohra R, Sch?ning W, Klawitter J, Brunner N, Schmitz V, Shokati T, Lawrence R, Arbelaez MF, Schniedewind B, Christians U, Klawitter J. Everolimus and sirolimus in combination with cyclosporine have different effects on renal metabolism in the rat. PLoS One. 2012; 7(10):e48063.
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Klawitter J, Haschke M, Shokati T, Klawitter J, Christians U. Quantification of 15-F2t-isoprostane in human plasma and urine: results from enzyme-linked immunoassay and liquid chromatography/tandem mass spectrometry cannot be compared. Rapid Commun Mass Spectrom. 2011 Feb 28; 25(4):463-8.
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Thethi T, Rajapurkar M, Walker P, McDuffie R, Goff DC, Probstfield J, Yau CL, Shah S, Christians U, Buse J, Fonseca V. Urinary catalytic iron in patients with type 2 diabetes without microalbuminuria--a substudy of the ACCORD Trial. Clin Chem. 2011 Feb; 57(2):341-4.
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Klawitter J, Haschke M, Kahle C, Dingmann C, Klawitter J, Leibfritz D, Christians U. Toxicodynamic effects of ciclosporin are reflected by metabolite profiles in the urine of healthy individuals after a single dose. Br J Clin Pharmacol. 2010 Aug; 70(2):241-51.
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Cruz D, Watson AD, Miller CS, Montoya D, Ochoa MT, Sieling PA, Gutierrez MA, Navab M, Reddy ST, Witztum JL, Fogelman AM, Rea TH, Eisenberg D, Berliner J, Modlin RL. Host-derived oxidized phospholipids and HDL regulate innate immunity in human leprosy. J Clin Invest. 2008 Aug; 118(8):2917-28.
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Ringman JM, Younkin SG, Pratico D, Seltzer W, Cole GM, Geschwind DH, Rodriguez-Agudelo Y, Schaffer B, Fein J, Sokolow S, Rosario ER, Gylys KH, Varpetian A, Medina LD, Cummings JL. Biochemical markers in persons with preclinical familial Alzheimer disease. Neurology. 2008 Jul 08; 71(2):85-92.
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Farias SE, Basselin M, Chang L, Heidenreich KA, Rapoport SI, Murphy RC. Formation of eicosanoids, E2/D2 isoprostanes, and docosanoids following decapitation-induced ischemia, measured in high-energy-microwaved rat brain. J Lipid Res. 2008 Sep; 49(9):1990-2000.
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Komakula S, Khatri S, Mermis J, Savill S, Haque S, Rojas M, Brown L, Teague GW, Holguin F. Body mass index is associated with reduced exhaled nitric oxide and higher exhaled 8-isoprostanes in asthmatics. Respir Res. 2007 Apr 16; 8:32.
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Lakshminrusimha S, Russell JA, Wedgwood S, Gugino SF, Kazzaz JA, Davis JM, Steinhorn RH. Superoxide dismutase improves oxygenation and reduces oxidation in neonatal pulmonary hypertension. Am J Respir Crit Care Med. 2006 Dec 15; 174(12):1370-7.
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