 Receptors, N-Methyl-D-Aspartate
"Receptors, N-Methyl-D-Aspartate" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A class of ionotropic glutamate receptors characterized by affinity for N-methyl-D-aspartate. NMDA receptors have an allosteric binding site for glycine which must be occupied for the channel to open efficiently and a site within the channel itself to which magnesium ions bind in a voltage-dependent manner. The positive voltage dependence of channel conductance and the high permeability of the conducting channel to calcium ions (as well as to monovalent cations) are important in excitotoxicity and neuronal plasticity.
| Descriptor ID |
D016194
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| MeSH Number(s) |
D12.776.157.530.400.400.500.500 D12.776.543.550.450.500.200.500 D12.776.543.585.400.500.200.500 D12.776.543.750.720.200.450.400.500
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| Concept/Terms |
Receptors, N-Methyl-D-Aspartate- Receptors, N-Methyl-D-Aspartate
- Receptors, N Methyl D Aspartate
- N-Methyl-D-Aspartate Receptors
- N Methyl D Aspartate Receptors
- NMDA Receptors
- Receptors, N-Methylaspartate
- Receptors, N Methylaspartate
- Receptors, NMDA
- NMDA Receptor-Ionophore Complex
- NMDA Receptor Ionophore Complex
- N-Methylaspartate Receptors
- N Methylaspartate Receptors
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Below are MeSH descriptors whose meaning is more general than "Receptors, N-Methyl-D-Aspartate".
- Chemicals and Drugs [D]
- Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
- Carrier Proteins [D12.776.157]
- Membrane Transport Proteins [D12.776.157.530]
- Ion Channels [D12.776.157.530.400]
- Ligand-Gated Ion Channels [D12.776.157.530.400.400]
- Receptors, Ionotropic Glutamate [D12.776.157.530.400.400.500]
- Receptors, N-Methyl-D-Aspartate [D12.776.157.530.400.400.500.500]
- Membrane Proteins [D12.776.543]
- Membrane Glycoproteins [D12.776.543.550]
- Ion Channels [D12.776.543.550.450]
- Ligand-Gated Ion Channels [D12.776.543.550.450.500]
- Receptors, Ionotropic Glutamate [D12.776.543.550.450.500.200]
- Receptors, N-Methyl-D-Aspartate [D12.776.543.550.450.500.200.500]
- Membrane Transport Proteins [D12.776.543.585]
- Ion Channels [D12.776.543.585.400]
- Ligand-Gated Ion Channels [D12.776.543.585.400.500]
- Receptors, Ionotropic Glutamate [D12.776.543.585.400.500.200]
- Receptors, N-Methyl-D-Aspartate [D12.776.543.585.400.500.200.500]
- Receptors, Cell Surface [D12.776.543.750]
- Receptors, Neurotransmitter [D12.776.543.750.720]
- Receptors, Amino Acid [D12.776.543.750.720.200]
- Receptors, Glutamate [D12.776.543.750.720.200.450]
- Receptors, Ionotropic Glutamate [D12.776.543.750.720.200.450.400]
- Receptors, N-Methyl-D-Aspartate [D12.776.543.750.720.200.450.400.500]
Below are MeSH descriptors whose meaning is more specific than "Receptors, N-Methyl-D-Aspartate".
This graph shows the total number of publications written about "Receptors, N-Methyl-D-Aspartate" by people in this website by year, and whether "Receptors, N-Methyl-D-Aspartate" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 1995 | 0 | 1 | 1 | | 1996 | 1 | 0 | 1 | | 1998 | 2 | 0 | 2 | | 1999 | 1 | 2 | 3 | | 2000 | 2 | 0 | 2 | | 2001 | 5 | 1 | 6 | | 2002 | 6 | 0 | 6 | | 2003 | 3 | 3 | 6 | | 2004 | 1 | 3 | 4 | | 2005 | 6 | 2 | 8 | | 2006 | 3 | 5 | 8 | | 2007 | 5 | 4 | 9 | | 2008 | 3 | 0 | 3 | | 2009 | 1 | 2 | 3 | | 2010 | 5 | 1 | 6 | | 2011 | 4 | 2 | 6 | | 2012 | 1 | 3 | 4 | | 2013 | 1 | 3 | 4 | | 2014 | 6 | 7 | 13 | | 2015 | 3 | 3 | 6 | | 2016 | 7 | 2 | 9 | | 2017 | 3 | 6 | 9 | | 2018 | 2 | 4 | 6 | | 2019 | 2 | 3 | 5 | | 2020 | 3 | 1 | 4 | | 2021 | 2 | 1 | 3 | | 2022 | 1 | 1 | 2 | | 2023 | 4 | 1 | 5 | | 2024 | 4 | 1 | 5 | | 2025 | 1 | 1 | 2 |
To return to the timeline, click here.
Below are the most recent publications written about "Receptors, N-Methyl-D-Aspartate" by people in Profiles.
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Brown CN, Blaine RE, Barker CM, Coultrap SJ, Bayer KU. The neuroprotective ?-hydroxybutyrate analog 3-hydroxycyclopent-1-enecarboxylic acid does not directly affect CaMKIIa autophosphorylation at T286 or binding to GluN2B. Mol Pharmacol. 2025 Apr; 107(4):100029.
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Gresch A, Osthues J, H?wel JD, Briggs JK, Berger T, Koch R, Deickert T, Beecks C, Benninger RKP, D?fer M. Resolving Spatiotemporal Electrical Signaling Within the Islet via CMOS Microelectrode Arrays. Diabetes. 2025 Mar 01; 74(3):343-354.
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Rumian NL, Barker CM, Larsen ME, Tullis JE, Freund RK, Taslimi A, Coultrap SJ, Tucker CL, Dell'Acqua ML, Bayer KU. LTP expression mediated by autonomous activity of GluN2B-bound CaMKII. Cell Rep. 2024 10 22; 43(10):114866.
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Prikhodko O, Freund RK, Sullivan E, Kennedy MJ, Dell'Acqua ML. Amyloid-? Causes NMDA Receptor Dysfunction and Dendritic Spine Loss through mGluR1 and AKAP150-Anchored Calcineurin Signaling. J Neurosci. 2024 Sep 11; 44(37).
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Dittmer PJ, Dell'Acqua ML. L-type Ca2+ channel activation of STIM1-Orai1 signaling remodels the dendritic spine ER to maintain long-term structural plasticity. Proc Natl Acad Sci U S A. 2024 Aug 27; 121(35):e2407324121.
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Sim?es de Oliveira L, O'Leary HE, Nawaz S, Loureiro R, Davenport EC, Baxter P, Louros SR, Dando O, Perkins E, Peltier J, Trost M, Osterweil EK, Hardingham GE, Cousin MA, Chattarji S, Booker SA, Benke TA, Wyllie DJA, Kind PC. Enhanced hippocampal LTP but normal NMDA receptor and AMPA receptor function in a rat model of CDKL5 deficiency disorder. Mol Autism. 2024 06 14; 15(1):28.
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Xu Y, Song R, Perszyk RE, Chen W, Kim S, Park KL, Allen JP, Nocilla KA, Zhang J, XiangWei W, Tankovic A, McDaniels ED, Sheikh R, Mizu RK, Karamchandani MM, Hu C, Kusumoto H, Pecha J, Cappuccio G, Gaitanis J, Sullivan J, Shashi V, Petrovski S, Jauss RT, Lee HK, Bozarth X, Lynch DR, Helbig I, Pierson TM, Boerkoel CF, Myers SJ, Lemke JR, Benke TA, Yuan H, Traynelis SF. De novo GRIN variants in M3 helix associated with neurological disorders control channel gating of NMDA receptor. Cell Mol Life Sci. 2024 Mar 28; 81(1):153.
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Camp CR, Vlachos A, Kl?ckner C, Krey I, Banke TG, Shariatzadeh N, Ruggiero SM, Galer P, Park KL, Caccavano A, Kimmel S, Yuan X, Yuan H, Helbig I, Benke TA, Lemke JR, Pelkey KA, McBain CJ, Traynelis SF. Loss of Grin2a causes a transient delay in the electrophysiological maturation of hippocampal parvalbumin interneurons. Commun Biol. 2023 09 19; 6(1):952.
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Myers SJ, Yuan H, Perszyk RE, Zhang J, Kim S, Nocilla KA, Allen JP, Bain JM, Lemke JR, Lal D, Benke TA, Traynelis SF. Classification of missense variants in the N-methyl-d-aspartate receptor GRIN gene family as gain- or loss-of-function. Hum Mol Genet. 2023 09 16; 32(19):2857-2871.
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Song R, Zhang J, Perszyk RE, Camp CR, Tang W, Kannan V, Li J, Xu Y, Chen J, Li Y, Liang SH, Traynelis SF, Yuan H. Differential responses of disease-related GRIN variants located in pore-forming M2 domain of N-methyl-D-aspartate receptor to FDA-approved inhibitors. J Neurochem. 2024 Dec; 168(12):3936-3949.
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