 Focal Adhesion Protein-Tyrosine Kinases
"Focal Adhesion Protein-Tyrosine Kinases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of non-receptor, PROLINE-rich protein-tyrosine kinases.
| Descriptor ID |
D051416
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| MeSH Number(s) |
D08.811.913.696.620.682.725.049 D12.644.360.287 D12.776.476.287
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| Concept/Terms |
Focal Adhesion Protein-Tyrosine Kinases- Focal Adhesion Protein-Tyrosine Kinases
- Focal Adhesion Protein Tyrosine Kinases
- Focal Adhesion Protein-Tyrosine Kinase Family
- Focal Adhesion Protein Tyrosine Kinase Family
- Focal Adhesion Kinase
- Focal Adhesion Protein-Tyrosine Kinase
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Below are MeSH descriptors whose meaning is more general than "Focal Adhesion Protein-Tyrosine Kinases".
Below are MeSH descriptors whose meaning is more specific than "Focal Adhesion Protein-Tyrosine Kinases".
This graph shows the total number of publications written about "Focal Adhesion Protein-Tyrosine Kinases" by people in this website by year, and whether "Focal Adhesion Protein-Tyrosine Kinases" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 1996 | 0 | 1 | 1 | | 2002 | 0 | 1 | 1 | | 2003 | 0 | 5 | 5 | | 2008 | 1 | 0 | 1 | | 2009 | 1 | 0 | 1 | | 2011 | 0 | 2 | 2 | | 2014 | 1 | 0 | 1 | | 2015 | 1 | 2 | 3 | | 2019 | 0 | 2 | 2 | | 2020 | 1 | 0 | 1 |
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Below are the most recent publications written about "Focal Adhesion Protein-Tyrosine Kinases" by people in Profiles.
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Jordan KR, Hall JK, Schedin T, Borakove M, Xian JJ, Dzieciatkowska M, Lyons TR, Schedin P, Hansen KC, Borges VF. Extracellular vesicles from young women's breast cancer patients drive increased invasion of non-malignant cells via the Focal Adhesion Kinase pathway: a proteomic approach. Breast Cancer Res. 2020 11 23; 22(1):128.
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Gerber DE, Camidge DR, Morgensztern D, Cetnar J, Kelly RJ, Ramalingam SS, Spigel DR, Jeong W, Scaglioni PP, Zhang S, Li M, Weaver DT, Vaikus L, Keegan M, Horobin JC, Burns TF. Phase 2 study of the focal adhesion kinase inhibitor defactinib (VS-6063) in previously treated advanced KRAS mutant non-small cell lung cancer. Lung Cancer. 2020 01; 139:60-67.
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Lu S, Weiser-Evans MCM. Nuclear Focal Adhesion Kinase. Circ Res. 2019 07 05; 125(2):167-169.
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Wang Q, Wang Y, Downey GP, Plotnikov S, McCulloch CA. A ternary complex comprising FAK, PTPa and IP3 receptor 1 functionally engages focal adhesions and the endoplasmic reticulum to mediate IL-1-induced Ca2+ signalling in fibroblasts. Biochem J. 2016 Feb 15; 473(4):397-410.
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Tsou PS, Amin MA, Campbell PL, Zakhem G, Balogh B, Edhayan G, Ohara RA, Schiopu E, Khanna D, Koch AE, Fox DA. Activation of the Thromboxane A2 Receptor by 8-Isoprostane Inhibits the Pro-Angiogenic Effect of Vascular Endothelial Growth Factor in Scleroderma. J Invest Dermatol. 2015 Dec; 135(12):3153-3162.
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Hendesi H, Barbe MF, Safadi FF, Monroy MA, Popoff SN. Integrin mediated adhesion of osteoblasts to connective tissue growth factor (CTGF/CCN2) induces cytoskeleton reorganization and cell differentiation. PLoS One. 2015; 10(2):e0115325.
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Wang Q, Wang Y, Fritz D, Rajshankar D, Downey GP, McCulloch CA. Interactions of the protein-tyrosine phosphatase-a with the focal adhesion targeting domain of focal adhesion kinase are involved in interleukin-1 signaling in fibroblasts. J Biol Chem. 2014 Jun 27; 289(26):18427-41.
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Yousif NG. Fibronectin promotes migration and invasion of ovarian cancer cells through up-regulation of FAK-PI3K/Akt pathway. Cell Biol Int. 2014 Jan; 38(1):85-91.
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Rogers AE, Le JP, Sather S, Pernu BM, Graham DK, Pierce AM, Keating AK. Mer receptor tyrosine kinase inhibition impedes glioblastoma multiforme migration and alters cellular morphology. Oncogene. 2012 Sep 20; 31(38):4171-81.
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Banerjee A, Kim BJ, Carmona EM, Cutting AS, Gurney MA, Carlos C, Feuer R, Prasadarao NV, Doran KS. Bacterial Pili exploit integrin machinery to promote immune activation and efficient blood-brain barrier penetration. Nat Commun. 2011 Sep 06; 2:462.
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