 Wnt Proteins
"Wnt Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Wnt proteins are a large family of secreted glycoproteins that play essential roles in EMBRYONIC AND FETAL DEVELOPMENT, and tissue maintenance. They bind to FRIZZLED RECEPTORS and act as PARACRINE PROTEIN FACTORS to initiate a variety of SIGNAL TRANSDUCTION PATHWAYS. The canonical Wnt signaling pathway stabilizes the transcriptional coactivator BETA CATENIN.
| Descriptor ID |
D051153
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| MeSH Number(s) |
D12.776.467.984 D23.529.984
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Wnt Proteins".
Below are MeSH descriptors whose meaning is more specific than "Wnt Proteins".
This graph shows the total number of publications written about "Wnt Proteins" by people in this website by year, and whether "Wnt Proteins" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 1 | 1 | | 1997 | 0 | 1 | 1 | | 1999 | 0 | 2 | 2 | | 2000 | 0 | 3 | 3 | | 2001 | 0 | 3 | 3 | | 2002 | 0 | 2 | 2 | | 2003 | 0 | 1 | 1 | | 2004 | 0 | 6 | 6 | | 2005 | 1 | 6 | 7 | | 2006 | 3 | 2 | 5 | | 2007 | 6 | 1 | 7 | | 2008 | 8 | 3 | 11 | | 2009 | 4 | 2 | 6 | | 2010 | 10 | 5 | 15 | | 2011 | 5 | 4 | 9 | | 2012 | 4 | 1 | 5 | | 2013 | 4 | 2 | 6 | | 2014 | 6 | 2 | 8 | | 2015 | 3 | 2 | 5 | | 2016 | 2 | 4 | 6 | | 2017 | 4 | 2 | 6 | | 2018 | 1 | 3 | 4 | | 2020 | 1 | 1 | 2 |
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Below are the most recent publications written about "Wnt Proteins" by people in Profiles.
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Vladar EK, Königshoff M. Noncanonical Wnt planar cell polarity signaling in lung development and disease. Biochem Soc Trans. 2020 02 28; 48(1):231-243.
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Fendler A, Bauer D, Busch J, Jung K, Wulf-Goldenberg A, Kunz S, Song K, Myszczyszyn A, Elezkurtaj S, Erguen B, Jung S, Chen W, Birchmeier W. Inhibiting WNT and NOTCH in renal cancer stem cells and the implications for human patients. Nat Commun. 2020 02 17; 11(1):929.
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Wang Y, Cho C, Williams J, Smallwood PM, Zhang C, Junge HJ, Nathans J. Interplay of the Norrin and Wnt7a/Wnt7b signaling systems in blood-brain barrier and blood-retina barrier development and maintenance. Proc Natl Acad Sci U S A. 2018 12 11; 115(50):E11827-E11836.
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Guimaraes PPG, Tan M, Tammela T, Wu K, Chung A, Oberli M, Wang K, Spektor R, Riley RS, Viana CTR, Jacks T, Langer R, Mitchell MJ. Potent in vivo lung cancer Wnt signaling inhibition via cyclodextrin-LGK974 inclusion complexes. J Control Release. 2018 11 28; 290:75-87.
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Merks AM, Swinarski M, Meyer AM, Müller NV, Özcan I, Donat S, Burger A, Gilbert S, Mosimann C, Abdelilah-Seyfried S, Panáková D. Planar cell polarity signalling coordinates heart tube remodelling through tissue-scale polarisation of actomyosin activity. Nat Commun. 2018 06 04; 9(1):2161.
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Burgy O, Königshoff M. The WNT signaling pathways in wound healing and fibrosis. Matrix Biol. 2018 08; 68-69:67-80.
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Lee NK, Zhang Y, Su Y, Bidlingmaier S, Sherbenou DW, Ha KD, Liu B. Cell-type specific potent Wnt signaling blockade by bispecific antibody. Sci Rep. 2018 01 15; 8(1):766.
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Dhar D, Raina K, Agarwal R. Mechanisms and Drug Targets for Pancreatic Cancer Chemoprevention. Curr Med Chem. 2018; 25(22):2545-2565.
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Wallace J, Lutgen V, Avasarala S, St Croix B, Winn RA, Al-Harthi L. Wnt7a induces a unique phenotype of monocyte-derived macrophages with lower phagocytic capacity and differential expression of pro- and anti-inflammatory cytokines. Immunology. 2018 02; 153(2):203-213.
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Skronska-Wasek W, Mutze K, Baarsma HA, Bracke KR, Alsafadi HN, Lehmann M, Costa R, Stornaiuolo M, Novellino E, Brusselle GG, Wagner DE, Yildirim AÖ, Königshoff M. Reduced Frizzled Receptor 4 Expression Prevents WNT/ß-Catenin-driven Alveolar Lung Repair in Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med. 2017 07 15; 196(2):172-185.
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