 Fibroblast Growth Factor 1
"Fibroblast Growth Factor 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A 17-kDa single-chain polypeptide growth factor that plays a significant role in the process of WOUND HEALING and is a potent inducer of PHYSIOLOGIC ANGIOGENESIS. It binds to HEPARIN, which potentiates its biological activity and protects it from proteolysis. The growth factor is an extremely potent inducer of DNA synthesis in a variety of cell types from mesoderm and neuroectoderm lineages, and also has chemotactic and mitogenic activities. It was originally named acidic fibroblast growth factor based upon its chemical properties and to distinguish it from basic fibroblast growth factor (FIBROBLAST GROWTH FACTOR 2).
| Descriptor ID |
D016220
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| MeSH Number(s) |
D12.644.276.624.110 D12.776.467.624.110 D23.529.624.110
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| Concept/Terms |
Fibroblast Growth Factor 1- Fibroblast Growth Factor 1
- HBGF-1
- Heparin-Binding Fibroblast Growth Factor Class I
- Heparin-Binding Growth Factor, Class I
- Heparin Binding Growth Factor, Class I
- Fibroblast Growth Factor, Acidic
- Fibroblast Growth Factor-1
- Class I Heparin-Binding Growth Factor
- FGF-1
- FGF1
- Acidic Fibroblast Growth Factor
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Below are MeSH descriptors whose meaning is more general than "Fibroblast Growth Factor 1".
Below are MeSH descriptors whose meaning is more specific than "Fibroblast Growth Factor 1".
This graph shows the total number of publications written about "Fibroblast Growth Factor 1" by people in this website by year, and whether "Fibroblast Growth Factor 1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1992 | 1 | 0 | 1 | | 1993 | 1 | 0 | 1 | | 1994 | 0 | 2 | 2 | | 1996 | 1 | 0 | 1 | | 1997 | 2 | 0 | 2 | | 1999 | 0 | 1 | 1 | | 2013 | 0 | 1 | 1 | | 2014 | 0 | 1 | 1 | | 2018 | 0 | 1 | 1 |
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Below are the most recent publications written about "Fibroblast Growth Factor 1" by people in Profiles.
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Laetsch TW, Roy A, Xu L, Black JO, Coffin CM, Chi YY, Tian J, Spunt SL, Hawkins DS, Bridge JA, Parsons DW, Skapek SX. Undifferentiated Sarcomas in Children Harbor Clinically Relevant Oncogenic Fusions and Gene Copy-Number Alterations: A Report from the Children's Oncology Group. Clin Cancer Res. 2018 08 15; 24(16):3888-3897.
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Bernet JD, Doles JD, Hall JK, Kelly Tanaka K, Carter TA, Olwin BB. p38 MAPK signaling underlies a cell-autonomous loss of stem cell self-renewal in skeletal muscle of aged mice. Nat Med. 2014 Mar; 20(3):265-71.
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Slattery ML, John EM, Stern MC, Herrick J, Lundgreen A, Giuliano AR, Hines L, Baumgartner KB, Torres-Mejia G, Wolff RK. Associations with growth factor genes (FGF1, FGF2, PDGFB, FGFR2, NRG2, EGF, ERBB2) with breast cancer risk and survival: the Breast Cancer Health Disparities Study. Breast Cancer Res Treat. 2013 Aug; 140(3):587-601.
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Van Belle E, Nikol S, Norgren L, Baumgartner I, Driver V, Hiatt WR, Belch J. Insights on the role of diabetes and geographic variation in patients with critical limb ischaemia. Eur J Vasc Endovasc Surg. 2011 Sep; 42(3):365-73.
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Belch J, Hiatt WR, Baumgartner I, Driver IV, Nikol S, Norgren L, Van Belle E. Effect of fibroblast growth factor NV1FGF on amputation and death: a randomised placebo-controlled trial of gene therapy in critical limb ischaemia. Lancet. 2011 Jun 04; 377(9781):1929-37.
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Petrash JM, Harter TM, Srivastava S, Chandra A, Bhatnagar A, Srivastava SK. Structure-function studies of FR-1. A growth factor-inducible aldo-keto reductase. Adv Exp Med Biol. 1999; 463:435-43.
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Goldman SA, Siegfried J, Scoleri P, Aydogen LB, Cass SP. The effect of acidic fibroblast growth factor and live yeast cell derivative on tympanic membrane regeneration in a rat model. Otolaryngol Head Neck Surg. 1997 Dec; 117(6):616-21.
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Zuber ME, Zhou Z, Burrus LW, Olwin BB. Cysteine-rich FGF receptor regulates intracellular FGF-1 and FGF-2 levels. J Cell Physiol. 1997 Mar; 170(3):217-27.
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Deterding RR, Jacoby CR, Shannon JM. Acidic fibroblast growth factor and keratinocyte growth factor stimulate fetal rat pulmonary epithelial growth. Am J Physiol. 1996 Oct; 271(4 Pt 1):L495-505.
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Dlugosz AA, Cheng C, Denning MF, Dempsey PJ, Coffey RJ, Yuspa SH. Keratinocyte growth factor receptor ligands induce transforming growth factor alpha expression and activate the epidermal growth factor receptor signaling pathway in cultured epidermal keratinocytes. Cell Growth Differ. 1994 Dec; 5(12):1283-92.
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