 Glucagon
"Glucagon" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A 29-amino acid pancreatic peptide derived from proglucagon which is also the precursor of intestinal GLUCAGON-LIKE PEPTIDES. Glucagon is secreted by PANCREATIC ALPHA CELLS and plays an important role in regulation of BLOOD GLUCOSE concentration, ketone metabolism, and several other biochemical and physiological processes. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1511)
| Descriptor ID |
D005934
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| MeSH Number(s) |
D06.472.699.587.469.500 D12.644.548.586.469.500
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| Concept/Terms |
Glucagon- Glucagon
- Proglucagon (33-61)
- HG-Factor
- HG Factor
- Hyperglycemic-Glycogenolytic Factor
- Hyperglycemic Glycogenolytic Factor
- Glucagon (1-29)
- Glukagon
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Below are MeSH descriptors whose meaning is more general than "Glucagon".
Below are MeSH descriptors whose meaning is more specific than "Glucagon".
This graph shows the total number of publications written about "Glucagon" by people in this website by year, and whether "Glucagon" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1991 | 0 | 1 | 1 | | 1994 | 1 | 0 | 1 | | 1996 | 1 | 1 | 2 | | 1997 | 1 | 0 | 1 | | 1998 | 0 | 1 | 1 | | 1999 | 0 | 3 | 3 | | 2000 | 0 | 1 | 1 | | 2001 | 1 | 0 | 1 | | 2002 | 1 | 1 | 2 | | 2003 | 1 | 1 | 2 | | 2004 | 1 | 3 | 4 | | 2005 | 0 | 4 | 4 | | 2006 | 1 | 1 | 2 | | 2007 | 0 | 4 | 4 | | 2009 | 0 | 4 | 4 | | 2011 | 1 | 2 | 3 | | 2012 | 1 | 2 | 3 | | 2013 | 1 | 0 | 1 | | 2014 | 0 | 1 | 1 | | 2015 | 2 | 0 | 2 | | 2016 | 3 | 1 | 4 | | 2017 | 1 | 0 | 1 | | 2018 | 0 | 1 | 1 | | 2019 | 0 | 1 | 1 | | 2020 | 2 | 1 | 3 | | 2021 | 0 | 1 | 1 |
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Below are the most recent publications written about "Glucagon" by people in Profiles.
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Cilvik SN, Wesolowski SR, Anthony RV, Brown LD, Rozance PJ. Late gestation fetal hyperglucagonaemia impairs placental function and results in diminished fetal protein accretion and decreased fetal growth. J Physiol. 2021 07; 599(13):3403-3427.
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Russell R, Carnese PP, Hennings TG, Walker EM, Russ HA, Liu JS, Giacometti S, Stein R, Hebrok M. Loss of the transcription factor MAFB limits ß-cell derivation from human PSCs. Nat Commun. 2020 06 02; 11(1):2742.
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Panaro BL, Yusta B, Matthews D, Koehler JA, Song Y, Sandoval DA, Drucker DJ. Intestine-selective reduction of Gcg expression reveals the importance of the distal gut for GLP-1 secretion. Mol Metab. 2020 07; 37:100990.
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Lowe RN, Trujillo JM. Intranasal Glucagon: A New Way to Treat Hypoglycemic Emergencies. Ann Pharmacother. 2020 08; 54(8):780-787.
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Singer RA, Arnes L, Cui Y, Wang J, Gao Y, Guney MA, Burnum-Johnson KE, Rabadan R, Ansong C, Orr G, Sussel L. The Long Noncoding RNA Paupar Modulates PAX6 Regulatory Activities to Promote Alpha Cell Development and Function. Cell Metab. 2019 12 03; 30(6):1091-1106.e8.
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Määttä J, Sissala N, Dimova EY, Serpi R, Moore LG, Koivunen P. Hypoxia causes reductions in birth weight by altering maternal glucose and lipid metabolism. Sci Rep. 2018 09 11; 8(1):13583.
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Lim S, Eckel RH, Koh KK. Clinical implications of current cardiovascular outcome trials with sodium glucose cotransporter-2 (SGLT2) inhibitors. Atherosclerosis. 2018 05; 272:33-40.
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Haymond MW, DuBose SN, Rickels MR, Wolpert H, Shah VN, Sherr JL, Weinstock RS, Agarwal S, Verdejo AS, Cummins MJ, Newswanger B, Beck RW. Efficacy and Safety of Mini-Dose Glucagon for Treatment of Nonsevere Hypoglycemia in Adults With Type 1 Diabetes. J Clin Endocrinol Metab. 2017 08 01; 102(8):2994-3001.
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Rickels MR, Ruedy KJ, Foster NC, Piché CA, Dulude H, Sherr JL, Tamborlane WV, Bethin KE, DiMeglio LA, Wadwa RP, Ahmann AJ, Haller MJ, Nathan BM, Marcovina SM, Rampakakis E, Meng L, Beck RW. Response to Comment on Rickels et al. Intranasal Glucagon for Treatment of Insulin-Induced Hypoglycemia in Adults With Type 1 Diabetes: A Randomized Crossover Noninferiority Study. Diabetes Care 2016;39:264-270. Diabetes Care. 2016 10; 39(10):e193-4.
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Ionut V, Woolcott OO, Mkrtchyan HJ, Stefanovski D, Kabir M, Iyer MS, Liu H, Castro AV, Wu Q, Broussard JL, Kolka CM, Asare-Bediako I, Bergman RN. Exenatide Treatment Alone Improves ß-Cell Function in a Canine Model of Pre-Diabetes. PLoS One. 2016; 11(7):e0158703.
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