 CD4-Positive T-Lymphocytes
"CD4-Positive T-Lymphocytes" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A critical subpopulation of T-lymphocytes involved in the induction of most immunological functions. The HIV virus has selective tropism for the T4 cell which expresses the CD4 phenotypic marker, a receptor for HIV. In fact, the key element in the profound immunosuppression seen in HIV infection is the depletion of this subset of T-lymphocytes.
| Descriptor ID |
D015496
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| MeSH Number(s) |
A11.118.637.555.567.569.200 A15.145.229.637.555.567.569.200 A15.382.490.555.567.569.200
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| Concept/Terms |
CD4-Positive T-Lymphocytes- CD4-Positive T-Lymphocytes
- CD4 Positive T Lymphocytes
- CD4-Positive T-Lymphocyte
- T-Lymphocyte, CD4-Positive
- T-Lymphocytes, CD4-Positive
- CD4-Positive Lymphocytes
- CD4-Positive Lymphocyte
- Lymphocyte, CD4-Positive
- Lymphocytes, CD4-Positive
- T4 Cells
- T4 Cell
- T4 Lymphocytes
- T4 Lymphocyte
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Below are MeSH descriptors whose meaning is more general than "CD4-Positive T-Lymphocytes".
Below are MeSH descriptors whose meaning is more specific than "CD4-Positive T-Lymphocytes".
This graph shows the total number of publications written about "CD4-Positive T-Lymphocytes" by people in this website by year, and whether "CD4-Positive T-Lymphocytes" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 1993 | 3 | 3 | 6 | | 1994 | 4 | 6 | 10 | | 1995 | 3 | 2 | 5 | | 1996 | 5 | 2 | 7 | | 1997 | 1 | 0 | 1 | | 1998 | 9 | 6 | 15 | | 1999 | 7 | 5 | 12 | | 2000 | 9 | 2 | 11 | | 2001 | 5 | 4 | 9 | | 2002 | 8 | 4 | 12 | | 2003 | 8 | 4 | 12 | | 2004 | 12 | 9 | 21 | | 2005 | 13 | 11 | 24 | | 2006 | 14 | 13 | 27 | | 2007 | 11 | 15 | 26 | | 2008 | 16 | 8 | 24 | | 2009 | 17 | 9 | 26 | | 2010 | 15 | 18 | 33 | | 2011 | 19 | 12 | 31 | | 2012 | 16 | 15 | 31 | | 2013 | 14 | 11 | 25 | | 2014 | 27 | 12 | 39 | | 2015 | 17 | 12 | 29 | | 2016 | 11 | 12 | 23 | | 2017 | 15 | 11 | 26 | | 2018 | 8 | 6 | 14 | | 2019 | 14 | 10 | 24 | | 2020 | 8 | 5 | 13 | | 2021 | 14 | 11 | 25 | | 2022 | 1 | 8 | 9 | | 2023 | 1 | 4 | 5 |
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Below are the most recent publications written about "CD4-Positive T-Lymphocytes" by people in Profiles.
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Letendre SL, Chen H, McKhann A, Roa J, Vecchio A, Daar ES, Berzins B, Hunt PW, Marra CM, Campbell TB, Coombs RW, Ma Q, Swaminathan S, Macatangay BJC, Morse GD, Miller T, Rusin D, Greninger AL, Ha B, Alston-Smith B, Robertson K, Paul R, Spudich S. Antiretroviral Therapy Intensification for Neurocognitive Impairment in Human Immunodeficiency Virus. Clin Infect Dis. 2023 09 18; 77(6):866-874.
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Sharma S, Tan X, Boyer J, Clarke D, Costanzo A, Abe B, Kain L, Holt M, Armstrong A, Rihanek M, Su A, Speake C, Gottlieb P, Gottschalk M, Pettus J, Teyton L. Measuring anti-islet autoimmunity in mouse and human by profiling peripheral blood antigen-specific CD4 T cells. Sci Transl Med. 2023 07 05; 15(703):eade3614.
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Kohler ME, Fry TJ. CD4+ CAR T cells - more than helpers. Nat Cancer. 2023 07; 4(7):928-929.
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Ogbechi J, Wright HL, Balint S, Topping LM, Kristina Z, Huang YS, Pantazi E, Swart M, Windell D, Marin E, Wempe MF, Endou H, Thomas AM, Filer A, Stone TW, Clarke AJ, Dustin ML, Williams RO. LAT1 enables T cell activation under inflammatory conditions. J Autoimmun. 2023 07; 138:103031.
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Patterson MT, Khan SM, Nunes NS, Fletcher RE, Bian J, Hadjis AD, Eckhaus MA, Mendu SK, de Paula Pohl A, Venzon DJ, Choo-Wosoba H, Ishii K, Qin H, Fry TJ, Cam M, Kanakry CG. Murine allogeneic CAR T cells integrated before or early after posttransplant cyclophosphamide exert antitumor effects. Blood. 2023 02 09; 141(6):659-672.
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Lesteberg KE, Araya P, Waugh KA, Chauhan L, Espinosa JM, Beckham JD. Severely ill and high-risk COVID-19 patients exhibit increased peripheral circulation of CD62L+ and perforin+ T cells. Front Immunol. 2023; 14:1113932.
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Crawford SA, Wiles TA, Wenzlau JM, Powell RL, Barbour G, Dang M, Groegler J, Barra JM, Burnette KS, Hohenstein AC, Baker RL, Tse HM, Haskins K, Delong T. Cathepsin D Drives the Formation of Hybrid Insulin Peptides Relevant to the Pathogenesis of Type 1 Diabetes. Diabetes. 2022 12 01; 71(12):2793-2803.
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Dvorak CC, Haddad E, Heimall J, Dunn E, Buckley RH, Kohn DB, Cowan MJ, Pai SY, Griffith LM, Cuvelier GDE, Eissa H, Shah AJ, O'Reilly RJ, Pulsipher MA, Wright NAM, Abraham RS, Satter LF, Notarangelo LD, Puck JM. The diagnosis of severe combined immunodeficiency (SCID): The Primary Immune Deficiency Treatment Consortium (PIDTC) 2022 Definitions. J Allergy Clin Immunol. 2023 02; 151(2):539-546.
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Fernandez-de C?spedes MV, Hoffman HK, Carter H, Simons LM, Naing L, Ablan SD, Scheiblin DA, Hultquist JF, van Engelenburg SB, Freed EO. Rab11-FIP1C Is Dispensable for HIV-1 Replication in Primary CD4+ T Cells, but Its Role Is Cell Type Dependent in Immortalized Human T-Cell Lines. J Virol. 2022 12 14; 96(23):e0087622.
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Li W, Li R, Wang Y, Zhang Y, Tomar MS, Dai S. Calcitonin gene-related peptide is a potential autoantigen for CD4 T cells in type 1 diabetes. Front Immunol. 2022; 13:951281.
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