 CD4-Positive T-Lymphocytes
"CD4-Positive T-Lymphocytes" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A critical subpopulation of T-lymphocytes involved in the induction of most immunological functions. The HIV virus has selective tropism for the T4 cell which expresses the CD4 phenotypic marker, a receptor for HIV. In fact, the key element in the profound immunosuppression seen in HIV infection is the depletion of this subset of T-lymphocytes.
| Descriptor ID |
D015496
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| MeSH Number(s) |
A11.118.637.555.567.569.200 A15.145.229.637.555.567.569.200 A15.382.490.555.567.569.200
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| Concept/Terms |
CD4-Positive T-Lymphocytes- CD4-Positive T-Lymphocytes
- CD4 Positive T Lymphocytes
- CD4-Positive T-Lymphocyte
- T-Lymphocyte, CD4-Positive
- T-Lymphocytes, CD4-Positive
- CD4-Positive Lymphocytes
- CD4-Positive Lymphocyte
- Lymphocyte, CD4-Positive
- Lymphocytes, CD4-Positive
- T4 Cells
- T4 Cell
- T4 Lymphocytes
- T4 Lymphocyte
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Below are MeSH descriptors whose meaning is more general than "CD4-Positive T-Lymphocytes".
Below are MeSH descriptors whose meaning is more specific than "CD4-Positive T-Lymphocytes".
This graph shows the total number of publications written about "CD4-Positive T-Lymphocytes" by people in this website by year, and whether "CD4-Positive T-Lymphocytes" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 1989 | 0 | 2 | 2 | | 1990 | 4 | 3 | 7 | | 1991 | 1 | 1 | 2 | | 1992 | 1 | 2 | 3 | | 1993 | 4 | 3 | 7 | | 1994 | 4 | 7 | 11 | | 1995 | 3 | 2 | 5 | | 1996 | 5 | 2 | 7 | | 1997 | 1 | 0 | 1 | | 1998 | 10 | 7 | 17 | | 1999 | 7 | 5 | 12 | | 2000 | 11 | 2 | 13 | | 2001 | 5 | 5 | 10 | | 2002 | 13 | 6 | 19 | | 2003 | 11 | 5 | 16 | | 2004 | 12 | 9 | 21 | | 2005 | 14 | 13 | 27 | | 2006 | 17 | 11 | 28 | | 2007 | 10 | 12 | 22 | | 2008 | 16 | 4 | 20 | | 2009 | 17 | 8 | 25 | | 2010 | 15 | 16 | 31 | | 2011 | 21 | 11 | 32 | | 2012 | 18 | 12 | 30 | | 2013 | 14 | 16 | 30 | | 2014 | 24 | 10 | 34 | | 2015 | 15 | 8 | 23 | | 2016 | 12 | 16 | 28 | | 2017 | 13 | 12 | 25 | | 2018 | 4 | 1 | 5 | | 2019 | 0 | 1 | 1 |
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Below are the most recent publications written about "CD4-Positive T-Lymphocytes" by people in Profiles.
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Jones D, Como CN, Jing L, Blackmon A, Neff CP, Krueger O, Bubak AN, Palmer BE, Koelle DM, Nagel MA. Varicella zoster virus productively infects human peripheral blood mononuclear cells to modulate expression of immunoinhibitory proteins and blocking PD-L1 enhances virus-specific CD8+ T cell effector function. PLoS Pathog. 2019 03; 15(3):e1007650.
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Collins CB, Puthoor PR, Nguyen TT, Strassheim D, Jedlicka P, Friedman JE, de Zoeten EF. C/EBPß Deletion Promotes Expansion of Poorly Functional Intestinal Regulatory T Cells. J Crohns Colitis. 2018 Nov 28; 12(12):1475-1485.
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Baker RL, Jamison BL, Wiles TA, Lindsay RS, Barbour G, Bradley B, Delong T, Friedman RS, Nakayama M, Haskins K. CD4 T Cells Reactive to Hybrid Insulin Peptides Are Indicators of Disease Activity in the NOD Mouse. Diabetes. 2018 09; 67(9):1836-1846.
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Schmitt K, Akkina R. Ultra-Sensitive HIV-1 Latency Viral Outgrowth Assays Using Humanized Mice. Front Immunol. 2018; 9:344.
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Zhou J, Lazar D, Li H, Xia X, Satheesan S, Charlins P, O'Mealy D, Akkina R, Saayman S, Weinberg MS, Rossi JJ, Morris KV. Receptor-targeted aptamer-siRNA conjugate-directed transcriptional regulation of HIV-1. Theranostics. 2018; 8(6):1575-1590.
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Harmacek LD, Patel P, Woolaver R, Reinhardt RL, O'Connor BP. Library Preparation for ATAC-Sequencing of Mouse CD4+ T Cells Isolated from the Lung and Lymph Nodes After Helminth Infection. Methods Mol Biol. 2018; 1799:327-340.
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Wang Y, Sosinowski T, Novikov A, Crawford F, Neau DB, Yang J, Kwok WW, Marrack P, Kappler JW, Dai S. C-terminal modification of the insulin B:11-23 peptide creates superagonists in mouse and human type 1 diabetes. Proc Natl Acad Sci U S A. 2018 01 02; 115(1):162-167.
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Yang Y, Kohler ME, Chien CD, Sauter CT, Jacoby E, Yan C, Hu Y, Wanhainen K, Qin H, Fry TJ. TCR engagement negatively affects CD8 but not CD4 CAR T cell expansion and leukemic clearance. Sci Transl Med. 2017 Nov 22; 9(417).
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Graybill C, Claypool DJ, Brinton JT, Levin MJ, Lee KS. Cytokines Produced in Response to Varicella-Zoster Virus Infection of ARPE-19 Cells Stimulate Lymphocyte Chemotaxis. J Infect Dis. 2017 11 15; 216(8):1038-1047.
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Kwak JW, Laskowski J, Li HY, McSharry MV, Sippel TR, Bullock BL, Johnson AM, Poczobutt JM, Neuwelt AJ, Malkoski SP, Weiser-Evans MC, Lambris JD, Clambey ET, Thurman JM, Nemenoff RA. Complement Activation via a C3a Receptor Pathway Alters CD4+ T Lymphocytes and Mediates Lung Cancer Progression. Cancer Res. 2018 01 01; 78(1):143-156.
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