 Peptide Chain Initiation, Translational
"Peptide Chain Initiation, Translational" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A process of GENETIC TRANSLATION whereby the formation of a peptide chain is started. It includes assembly of the RIBOSOME components, the MESSENGER RNA coding for the polypeptide to be made, INITIATOR TRNA, and PEPTIDE INITIATION FACTORS; and placement of the first amino acid in the peptide chain. The details and components of this process are unique for prokaryotic protein biosynthesis and eukaryotic protein biosynthesis.
| Descriptor ID |
D010442
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| MeSH Number(s) |
G02.111.660.871.650 G03.734.871.650
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| Concept/Terms |
Peptide Chain Initiation, Translational- Peptide Chain Initiation, Translational
- Chain Initiation, Peptide, Translational
- Protein Chain Initiation, Translational
- Protein Translation Initiation
- Translation Initiation, Protein
- Initiation, Protein Translation
- Protein Biosynthesis Initiation
- Biosynthesis Initiation, Protein
- Initiation, Protein Biosynthesis
- Translation Initiation, Genetic
- Genetic Translation Initiation
- Initiation, Genetic Translation
- Translational Peptide Chain Initiation
- Translational Initiation, Protein
- Initiation, Protein Translational
- Protein Translational Initiation
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Below are MeSH descriptors whose meaning is more general than "Peptide Chain Initiation, Translational".
Below are MeSH descriptors whose meaning is more specific than "Peptide Chain Initiation, Translational".
This graph shows the total number of publications written about "Peptide Chain Initiation, Translational" by people in this website by year, and whether "Peptide Chain Initiation, Translational" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1991 | 2 | 0 | 2 | | 1993 | 1 | 0 | 1 | | 1994 | 1 | 0 | 1 | | 1995 | 0 | 1 | 1 | | 1999 | 1 | 0 | 1 | | 2001 | 2 | 0 | 2 | | 2002 | 1 | 0 | 1 | | 2007 | 1 | 0 | 1 | | 2008 | 0 | 1 | 1 | | 2009 | 1 | 1 | 2 | | 2011 | 2 | 0 | 2 | | 2012 | 2 | 1 | 3 | | 2013 | 1 | 0 | 1 | | 2015 | 0 | 2 | 2 | | 2016 | 3 | 1 | 4 | | 2019 | 1 | 0 | 1 |
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Below are the most recent publications written about "Peptide Chain Initiation, Translational" by people in Profiles.
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Tauber D, Parker R. 15-Deoxy-?12,14-prostaglandin J2 promotes phosphorylation of eukaryotic initiation factor 2a and activates the integrated stress response. J Biol Chem. 2019 04 19; 294(16):6344-6352.
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Jaafar ZA, Oguro A, Nakamura Y, Kieft JS. Translation initiation by the hepatitis C virus IRES requires eIF1A and ribosomal complex remodeling. Elife. 2016 12 23; 5.
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Hussain T, Llácer JL, Wimberly BT, Kieft JS, Ramakrishnan V. Large-Scale Movements of IF3 and tRNA during Bacterial Translation Initiation. Cell. 2016 Sep 22; 167(1):133-144.e13.
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Wheeler JR, Matheny T, Jain S, Abrisch R, Parker R. Distinct stages in stress granule assembly and disassembly. Elife. 2016 09 07; 5.
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Martin F, Ménétret JF, Simonetti A, Myasnikov AG, Vicens Q, Prongidi-Fix L, Natchiar SK, Klaholz BP, Eriani G. Ribosomal 18S rRNA base pairs with mRNA during eukaryotic translation initiation. Nat Commun. 2016 08 24; 7:12622.
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Colussi TM, Costantino DA, Zhu J, Donohue JP, Korostelev AA, Jaafar ZA, Plank TD, Noller HF, Kieft JS. Initiation of translation in bacteria by a structured eukaryotic IRES RNA. Nature. 2015 Mar 05; 519(7541):110-3.
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Van Rechem C, Black JC, Boukhali M, Aryee MJ, Gräslund S, Haas W, Benes CH, Whetstine JR. Lysine demethylase KDM4A associates with translation machinery and regulates protein synthesis. Cancer Discov. 2015 Mar; 5(3):255-63.
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Vasquez JJ, Hon CC, Vanselow JT, Schlosser A, Siegel TN. Comparative ribosome profiling reveals extensive translational complexity in different Trypanosoma brucei life cycle stages. Nucleic Acids Res. 2014 Apr; 42(6):3623-37.
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Plank TD, Whitehurst JT, Kieft JS. Cell type specificity and structural determinants of IRES activity from the 5' leaders of different HIV-1 transcripts. Nucleic Acids Res. 2013 Jul; 41(13):6698-714.
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Filbin ME, Vollmar BS, Shi D, Gonen T, Kieft JS. HCV IRES manipulates the ribosome to promote the switch from translation initiation to elongation. Nat Struct Mol Biol. 2013 Feb; 20(2):150-8.
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