 Extracellular Signal-Regulated MAP Kinases
"Extracellular Signal-Regulated MAP Kinases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A mitogen-activated protein kinase subfamily that is widely expressed and plays a role in regulation of MEIOSIS; MITOSIS; and post mitotic functions in differentiated cells. The extracellular signal regulated MAP kinases are regulated by a broad variety of CELL SURFACE RECEPTORS and can be activated by certain CARCINOGENS.
| Descriptor ID |
D048049
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| MeSH Number(s) |
D08.811.913.696.620.682.700.567.249 D12.644.360.450.169 D12.776.476.450.169
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| Concept/Terms |
Extracellular Signal-Regulated MAP Kinases- Extracellular Signal-Regulated MAP Kinases
- Extracellular Signal Regulated MAP Kinases
- MAP Kinases, Extracellular Signal-Regulated
- MAP Kinases, Extracellular Signal Regulated
- ERK MAP Kinases
- Extracellular Signal-Regulated Kinases
- Extracellular Signal Regulated Kinases
- Kinases, Extracellular Signal-Regulated
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Below are MeSH descriptors whose meaning is more general than "Extracellular Signal-Regulated MAP Kinases".
Below are MeSH descriptors whose meaning is more specific than "Extracellular Signal-Regulated MAP Kinases".
This graph shows the total number of publications written about "Extracellular Signal-Regulated MAP Kinases" by people in this website by year, and whether "Extracellular Signal-Regulated MAP Kinases" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
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| 2004 | 1 | 1 | 2 | | 2005 | 3 | 3 | 6 | | 2006 | 3 | 9 | 12 | | 2007 | 0 | 6 | 6 | | 2008 | 2 | 5 | 7 | | 2009 | 2 | 8 | 10 | | 2010 | 3 | 4 | 7 | | 2011 | 4 | 3 | 7 | | 2012 | 1 | 5 | 6 | | 2013 | 2 | 6 | 8 | | 2014 | 1 | 7 | 8 | | 2015 | 2 | 4 | 6 | | 2016 | 1 | 5 | 6 | | 2017 | 1 | 2 | 3 | | 2018 | 0 | 1 | 1 | | 2019 | 2 | 2 | 4 | | 2020 | 2 | 2 | 4 | | 2021 | 0 | 1 | 1 |
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Below are the most recent publications written about "Extracellular Signal-Regulated MAP Kinases" by people in Profiles.
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Sripada A, Sirohi K, Michalec L, Guo L, McKay JT, Yadav S, Verma M, Good J, Rollins D, Gorska MM, Alam R. Sprouty2 positively regulates T cell function and airway inflammation through regulation of CSK and LCK kinases. PLoS Biol. 2021 03; 19(3):e3001063.
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Wang Q, Notay K, Downey GP, McCulloch CA. The Leucine-Rich Repeat Region of CARMIL1 Regulates IL-1-Mediated ERK Activation, MMP Expression, and Collagen Degradation. Cell Rep. 2020 06 30; 31(13):107781.
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Stern JL, Hibshman G, Hu K, Ferrara SE, Costello JC, Kim W, Tamayo P, Cech TR, Huang FW. Mesenchymal and MAPK Expression Signatures Associate with Telomerase Promoter Mutations in Multiple Cancers. Mol Cancer Res. 2020 07; 18(7):1050-1062.
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Neuwelt AJ, Kimball AK, Johnson AM, Arnold BW, Bullock BL, Kaspar RE, Kleczko EK, Kwak JW, Wu MH, Heasley LE, Doebele RC, Li HY, Nemenoff RA, Clambey ET. Cancer cell-intrinsic expression of MHC II in lung cancer cell lines is actively restricted by MEK/ERK signaling and epigenetic mechanisms. J Immunother Cancer. 2020 04; 8(1).
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Pozdeyev N, Rose MM, Bowles DW, Schweppe RE. Molecular therapeutics for anaplastic thyroid cancer. Semin Cancer Biol. 2020 04; 61:23-29.
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Castillo-Castrejon M, Jansson T, Powell TL. No evidence of attenuation of placental insulin-stimulated Akt phosphorylation and amino acid transport in maternal obesity and gestational diabetes mellitus. Am J Physiol Endocrinol Metab. 2019 12 01; 317(6):E1037-E1049.
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Pegram LM, Liddle JC, Xiao Y, Hoh M, Rudolph J, Iverson DB, Vigers GP, Smith D, Zhang H, Wang W, Moffat JG, Ahn NG. Activation loop dynamics are controlled by conformation-selective inhibitors of ERK2. Proc Natl Acad Sci U S A. 2019 07 30; 116(31):15463-15468.
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Aziz AH, Eckstein K, Ferguson VL, Bryant SJ. The effects of dynamic compressive loading on human mesenchymal stem cell osteogenesis in the stiff layer of a bilayer hydrogel. J Tissue Eng Regen Med. 2019 06; 13(6):946-959.
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Ohm AM, Affandi T, Reyland ME. EGF receptor and PKCd kinase activate DNA damage-induced pro-survival and pro-apoptotic signaling via biphasic activation of ERK and MSK1 kinases. J Biol Chem. 2019 03 22; 294(12):4488-4497.
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Greaves SA, Peterson JN, Torres RM, Pelanda R. Activation of the MEK-ERK Pathway Is Necessary but Not Sufficient for Breaking Central B Cell Tolerance. Front Immunol. 2018; 9:707.
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