 beta-N-Acetylhexosaminidases
"beta-N-Acetylhexosaminidases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A hexosaminidase specific for non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides. It acts on GLUCOSIDES; GALACTOSIDES; and several OLIGOSACCHARIDES. Two specific mammalian isoenzymes of beta-N-acetylhexoaminidase are referred to as HEXOSAMINIDASE A and HEXOSAMINIDASE B. Deficiency of the type A isoenzyme causes TAY-SACHS DISEASE, while deficiency of both A and B isozymes causes SANDHOFF DISEASE. The enzyme has also been used as a tumor marker to distinguish between malignant and benign disease.
| Descriptor ID |
D001619
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| MeSH Number(s) |
D08.811.277.450.483.180
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| Concept/Terms |
beta-N-Acetylhexosaminidases- beta-N-Acetylhexosaminidases
- beta N Acetylhexosaminidases
- N-Acetyl-beta-D-hexosaminidase
- N Acetyl beta D hexosaminidase
- beta-N-Acetyl-hexosaminidase
- beta N Acetyl hexosaminidase
- beta-N-Acetylhexosaminidase
- beta N Acetylhexosaminidase
- beta-Hexosaminidase
- beta Hexosaminidase
- beta-N-Acetyl-D-hexosaminidase
- beta N Acetyl D hexosaminidase
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Below are MeSH descriptors whose meaning is more general than "beta-N-Acetylhexosaminidases".
Below are MeSH descriptors whose meaning is more specific than "beta-N-Acetylhexosaminidases".
This graph shows the total number of publications written about "beta-N-Acetylhexosaminidases" by people in this website by year, and whether "beta-N-Acetylhexosaminidases" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 1 | 1 | | 2007 | 1 | 0 | 1 | | 2021 | 0 | 2 | 2 |
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Below are the most recent publications written about "beta-N-Acetylhexosaminidases" by people in Profiles.
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Nieto-Caballero M, Gomez OM, Shaughnessy R, Hernandez M. Aerosol fluorescence, airborne hexosaminidase, and quantitative genomics distinguish reductions in airborne fungal loads following major school renovations. Indoor Air. 2022 01; 32(1):e12975.
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Poczobutt JM, Mikosz AM, Poirier C, Beatman EL, Serban KA, Gally F, Cao D, McCubbrey AL, Cornell CF, Schweitzer KS, Berdyshev EV, Bronova IA, Paris F, Petrache I. Altered Macrophage Function Associated with Crystalline Lung Inflammation in Acid Sphingomyelinase Deficiency. Am J Respir Cell Mol Biol. 2021 05; 64(5):629-640.
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Manuel SG, Ragunath C, Sait HB, Izano EA, Kaplan JB, Ramasubbu N. Role of active-site residues of dispersin B, a biofilm-releasing beta-hexosaminidase from a periodontal pathogen, in substrate hydrolysis. FEBS J. 2007 Nov; 274(22):5987-99.
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Mahmudi-Azer S, Downey GP, Moqbel R. Translocation of the tetraspanin CD63 in association with human eosinophil mediator release. Blood. 2002 Jun 01; 99(11):4039-47.
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Lew DB, Leslie CC, Henson PM, Riches DW. Role of endogenously derived leukotrienes in the regulation of lysosomal enzyme expression in macrophages exposed to beta 1,3-glucan. J Leukoc Biol. 1991 Mar; 49(3):266-76.
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Lew DB, Leslie CC, Riches DW, Henson PM. Induction of macrophage lysosomal hydrolase synthesis and secretion by beta-1,3-glucan. Cell Immunol. 1986 Jul; 100(2):340-50.
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