Mucin-1
"Mucin-1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Carbohydrate antigen elevated in patients with tumors of the breast, ovary, lung, and prostate as well as other disorders. The mucin is expressed normally by most glandular epithelia but shows particularly increased expression in the breast at lactation and in malignancy. It is thus an established serum marker for breast cancer.
Descriptor ID |
D018396
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MeSH Number(s) |
D12.776.395.550.560 D12.776.395.560.631.115 D12.776.543.550.530 D23.050.285.050.300 D23.050.550.325.300 D23.101.140.075.300
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Concept/Terms |
Mucin-1- Mucin-1
- Mucin 1
- CA 15.3 Antigen
- Antigen, CA 15.3
- Antigen CA-15-3
- Antigen CA 15 3
- CA-15-3, Antigen
- CA-15-3 Antigen
- Antigen, CA-15-3
- Episialin
- CD227 Antigen
- Antigen, CD227
- Polymorphic Epithelial Mucin
- Epithelial Membrane Antigen
- Antigen, Epithelial Membrane
- Membrane Antigen, Epithelial
- Muc1 Mucin
- Mucin, Muc1
- Antigens, CD227
- CD227 Antigens
- CA 15-3 Antigen
- Antigen, CA 15-3
- CA 15 3 Antigen
- Epithelial Mucin, Polymorphic
- Mucin, Polymorphic Epithelial
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Below are MeSH descriptors whose meaning is more general than "Mucin-1".
- Chemicals and Drugs [D]
- Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
- Glycoproteins [D12.776.395]
- Membrane Glycoproteins [D12.776.395.550]
- Mucin-1 [D12.776.395.550.560]
- Mucoproteins [D12.776.395.560]
- Mucins [D12.776.395.560.631]
- Mucin-1 [D12.776.395.560.631.115]
- Membrane Proteins [D12.776.543]
- Membrane Glycoproteins [D12.776.543.550]
- Mucin-1 [D12.776.543.550.530]
- Biological Factors [D23]
- Antigens [D23.050]
- Antigens, Neoplasm [D23.050.285]
- Antigens, Tumor-Associated, Carbohydrate [D23.050.285.050]
- Mucin-1 [D23.050.285.050.300]
- Epitopes [D23.050.550]
- Antigens, Tumor-Associated, Carbohydrate [D23.050.550.325]
- Mucin-1 [D23.050.550.325.300]
- Biomarkers [D23.101]
- Biomarkers, Tumor [D23.101.140]
- Antigens, Tumor-Associated, Carbohydrate [D23.101.140.075]
- Mucin-1 [D23.101.140.075.300]
Below are MeSH descriptors whose meaning is more specific than "Mucin-1".
This graph shows the total number of publications written about "Mucin-1" by people in this website by year, and whether "Mucin-1" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
Year | Major Topic | Minor Topic | Total |
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1997 | 0 | 1 | 1 | 2003 | 0 | 1 | 1 | 2005 | 0 | 1 | 1 | 2007 | 1 | 0 | 1 | 2009 | 3 | 0 | 3 | 2010 | 1 | 0 | 1 | 2012 | 1 | 0 | 1 | 2016 | 0 | 1 | 1 | 2017 | 1 | 1 | 2 |
To return to the timeline, click here.
Below are the most recent publications written about "Mucin-1" by people in Profiles.
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Shukla SK, Purohit V, Mehla K, Gunda V, Chaika NV, Vernucci E, King RJ, Abrego J, Goode GD, Dasgupta A, Illies AL, Gebregiworgis T, Dai B, Augustine JJ, Murthy D, Attri KS, Mashadova O, Grandgenett PM, Powers R, Ly QP, Lazenby AJ, Grem JL, Yu F, Mat?s JM, Asara JM, Kim JW, Hankins JH, Weekes C, Hollingsworth MA, Serkova NJ, Sasson AR, Fleming JB, Oliveto JM, Lyssiotis CA, Cantley LC, Berim L, Singh PK. MUC1 and HIF-1alpha Signaling Crosstalk Induces Anabolic Glucose Metabolism to Impart Gemcitabine Resistance to Pancreatic Cancer. Cancer Cell. 2017 07 10; 32(1):71-87.e7.
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Amani V, Donson AM, Lummus SC, Prince EW, Griesinger AM, Witt DA, Hankinson TC, Handler MH, Dorris K, Vibhakar R, Foreman NK, Hoffman LM. Characterization of 2 Novel Ependymoma Cell Lines With Chromosome 1q Gain Derived From Posterior Fossa Tumors of Childhood. J Neuropathol Exp Neurol. 2017 Jul 01; 76(7):595-604.
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Karsai A, Slack TJ, Malekan H, Khoury F, Lin WF, Tran V, Cox D, Toney M, Chen X, Liu GY. Local Mechanical Perturbation Provides an Effective Means to Regulate the Growth and Assembly of Functional Peptide Fibrils. Small. 2016 Dec; 12(46):6407-6415.
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Horm TM, Bitler BG, Broka DM, Louderbough JM, Schroeder JA. MUC1 drives c-Met-dependent migration and scattering. Mol Cancer Res. 2012 Dec; 10(12):1544-54.
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Bitler BG, Goverdhan A, Schroeder JA. MUC1 regulates nuclear localization and function of the epidermal growth factor receptor. J Cell Sci. 2010 May 15; 123(Pt 10):1716-23.
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Doan ML, Elidemir O, Dishop MK, Zhang H, Smith EO, Black PG, Deterding RR, Roberts DM, Al-Salmi QA, Fan LL. Serum KL-6 differentiates neuroendocrine cell hyperplasia of infancy from the inborn errors of surfactant metabolism. Thorax. 2009 Aug; 64(8):677-81.
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Pegram MD, Borges VF, Ibrahim N, Fuloria J, Shapiro C, Perez S, Wang K, Schaedli Stark F, Courtenay Luck N. Phase I dose escalation pharmacokinetic assessment of intravenous humanized anti-MUC1 antibody AS1402 in patients with advanced breast cancer. Breast Cancer Res. 2009; 11(5):R73.
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Bitler BG, Menzl I, Huerta CL, Sands B, Knowlton W, Chang A, Schroeder JA. Intracellular MUC1 peptides inhibit cancer progression. Clin Cancer Res. 2009 Jan 01; 15(1):100-9.
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Pochampalli MR, Bitler BG, Schroeder JA. Transforming growth factor alpha dependent cancer progression is modulated by Muc1. Cancer Res. 2007 Jul 15; 67(14):6591-8.
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Walter JN, Fan LL, Bag R, Zhang H, Doan M, Mallory GB, Elidemir O. Serum KL-6 as a marker for bronchiolitis obliterans syndrome after lung transplantation. Transplantation. 2006 Sep 15; 82(5):709-11.
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