 Leydig Cells
"Leydig Cells" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Steroid-producing cells in the interstitial tissue of the TESTIS. They are under the regulation of PITUITARY HORMONES; LUTEINIZING HORMONE; or interstitial cell-stimulating hormone. TESTOSTERONE is the major androgen (ANDROGENS) produced.
| Descriptor ID |
D007985
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| MeSH Number(s) |
A05.360.444.849.513 A06.407.312.782.513 A11.382.906 A11.436.513
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| Concept/Terms |
Leydig Cells- Leydig Cells
- Cells, Leydig
- Testicular Interstitial Cells
- Interstitial Cells, Testicular
- Cell, Testicular Interstitial
- Cells, Testicular Interstitial
- Interstitial Cell, Testicular
- Testicular Interstitial Cell
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Below are MeSH descriptors whose meaning is more general than "Leydig Cells".
Below are MeSH descriptors whose meaning is more specific than "Leydig Cells".
This graph shows the total number of publications written about "Leydig Cells" by people in this website by year, and whether "Leydig Cells" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 1 | 1 | 2 | | 1998 | 0 | 1 | 1 | | 2003 | 1 | 1 | 2 | | 2004 | 0 | 2 | 2 |
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Below are the most recent publications written about "Leydig Cells" by people in Profiles.
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Motohashi M, Wempe MF, Mutou T, Okayama Y, Kansaku N, Takahashi H, Ikegami M, Asari M, Wakui S. In utero-exposed di(n-butyl) phthalate induce dose dependent, age-related changes of morphology and testosterone-biosynthesis enzymes/associated proteins of Leydig cell mitochondria in rats. J Toxicol Sci. 2016 Apr; 41(2):195-206.
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Motohashi M, Wempe MF, Mutou T, Takahashi H, Kansaku N, Ikegami M, Inomata T, Asari M, Wakui S. Male rats exposed in utero to di(n-butyl) phthalate: Age-related changes in Leydig cell smooth endoplasmic reticulum and testicular testosterone-biosynthesis enzymes/proteins. Reprod Toxicol. 2016 Jan; 59:139-46.
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Wakui S, Shirai M, Motohashi M, Mutou T, Oyama N, Wempe MF, Takahashi H, Inomata T, Ikegami M, Endou H, Asari M. Effects of in utero exposure to di(n-butyl) phthalate for estrogen receptors a, ?, and androgen receptor of Leydig cell on rats. Toxicol Pathol. 2014 Jul; 42(5):877-87.
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Shirai M, Wakui S, Wempe MF, Mutou T, Oyama N, Motohashi M, Takahashi H, Kansaku N, Asari M, Hano H, Endou H. Male Sprague-Dawley rats exposed to in utero di(n-butyl) phthalate: dose dependent and age-related morphological changes in Leydig cell smooth endoplasmic reticulum. Toxicol Pathol. 2013; 41(7):984-91.
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Ahn SW, Gang GT, Tadi S, Nedumaran B, Kim YD, Park JH, Kweon GR, Koo SH, Lee K, Ahn RS, Yim YH, Lee CH, Harris RA, Choi HS. Phosphoenolpyruvate carboxykinase and glucose-6-phosphatase are required for steroidogenesis in testicular Leydig cells. J Biol Chem. 2012 Dec 07; 287(50):41875-87.
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Wakui S, Takahashi H, Mutou T, Shirai M, Jutabha P, Anzai N, Wempe MF, Kansaku N, Hano H, Inomata T, Endou H. Atypical Leydig cell hyperplasia in adult rats with low T and high LH induced by prenatal Di(n-butyl) phthalate exposure. Toxicol Pathol. 2013; 41(3):480-6.
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Ahn SW, Nedumaran B, Xie Y, Kim DK, Kim YD, Choi HS. Bisphenol A bis(2,3-dihydroxypropyl) ether (BADGE.2H2O) induces orphan nuclear receptor Nur77 gene expression and increases steroidogenesis in mouse testicular Leydig cells. Mol Cells. 2008 Jul 31; 26(1):74-80.
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Ma X, Dong Y, Matzuk MM, Kumar TR. Targeted disruption of luteinizing hormone beta-subunit leads to hypogonadism, defects in gonadal steroidogenesis, and infertility. Proc Natl Acad Sci U S A. 2004 Dec 07; 101(49):17294-9.
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Hiroi H, Christenson LK, Chang L, Sammel MD, Berger SL, Strauss JF. Temporal and spatial changes in transcription factor binding and histone modifications at the steroidogenic acute regulatory protein (stAR) locus associated with stAR transcription. Mol Endocrinol. 2004 Apr; 18(4):791-806.
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Matzuk MM, DeMayo FJ, Hadsell LA, Kumar TR. Overexpression of human chorionic gonadotropin causes multiple reproductive defects in transgenic mice. Biol Reprod. 2003 Jul; 69(1):338-46.
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