 Protein Aggregates
"Protein Aggregates" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Any mixture of secondary, tertiary, or quaternary protein molecules which appear as clumps in or outside the cell.
| Descriptor ID |
D066329
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| MeSH Number(s) |
D05.875
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Protein Aggregates".
Below are MeSH descriptors whose meaning is more specific than "Protein Aggregates".
This graph shows the total number of publications written about "Protein Aggregates" by people in this website by year, and whether "Protein Aggregates" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2011 | 1 | 2 | 3 | | 2013 | 0 | 1 | 1 | | 2014 | 5 | 3 | 8 | | 2015 | 2 | 4 | 6 | | 2016 | 6 | 3 | 9 | | 2017 | 2 | 3 | 5 | | 2018 | 3 | 4 | 7 |
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Below are the most recent publications written about "Protein Aggregates" by people in Profiles.
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Shah DD, Singh SM, Mallela KMG. Effect of Chemical Oxidation on the Higher Order Structure, Stability, Aggregation, and Biological Function of Interferon Alpha-2a: Role of Local Structural Changes Detected by 2D NMR. Pharm Res. 2018 Oct 15; 35(12):232.
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Nejadnik MR, Randolph TW, Volkin DB, Schöneich C, Carpenter JF, Crommelin DJA, Jiskoot W. Postproduction Handling and Administration of Protein Pharmaceuticals and Potential Instability Issues. J Pharm Sci. 2018 08; 107(8):2013-2019.
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Gandhi AV, Arlotta KJ, Chen HN, Owen SC, Carpenter JF. Biophysical Properties and Heating-Induced Aggregation of Lysine-Conjugated Antibody-Drug Conjugates. J Pharm Sci. 2018 07; 107(7):1858-1869.
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Pardeshi NN, Zhou C, Randolph TW, Carpenter JF. Protein Nanoparticles Promote Microparticle Formation in Intravenous Immunoglobulin Solutions During Freeze-Thawing and Agitation Stresses. J Pharm Sci. 2018 07; 107(7):1852-1857.
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Schack MM, Møller EH, Carpenter JF, Rades T, Groenning M. A Platform for Preparing Homogeneous Proteinaceous Subvisible Particles With Distinct Morphologies. J Pharm Sci. 2018 07; 107(7):1842-1851.
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Sorret LL, DeWinter MA, Schwartz DK, Randolph TW. Protein-protein interactions controlling interfacial aggregation of rhIL-1ra are not described by simple colloid models. Protein Sci. 2018 07; 27(7):1191-1204.
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Daniels AL, Randolph TW. Flow Microscopy Imaging Is Sensitive to Characteristics of Subvisible Particles in Peginesatide Formulations Associated With Severe Adverse Reactions. J Pharm Sci. 2018 05; 107(5):1313-1321.
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Shah DD, Singh SM, Dzieciatkowska M, Mallela KMG. Biophysical analysis of the effect of chemical modification by 4-oxononenal on the structure, stability, and function of binding immunoglobulin protein (BiP). PLoS One. 2017; 12(9):e0183975.
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Gandhi AV, Pothecary MR, Bain DL, Carpenter JF. Some Lessons Learned From a Comparison Between Sedimentation Velocity Analytical Ultracentrifugation and Size Exclusion Chromatography to Characterize and Quantify Protein Aggregates. J Pharm Sci. 2017 08; 106(8):2178-2186.
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Dittmer PJ, Wild AR, Dell'Acqua ML, Sather WA. STIM1 Ca2+ Sensor Control of L-type Ca2+-Channel-Dependent Dendritic Spine Structural Plasticity and Nuclear Signaling. Cell Rep. 2017 04 11; 19(2):321-334.
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