 Protein Aggregates
"Protein Aggregates" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Any mixture of secondary, tertiary, or quaternary protein molecules which appear as clumps in or outside the cell.
| Descriptor ID |
D066329
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| MeSH Number(s) |
D05.875
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Protein Aggregates".
Below are MeSH descriptors whose meaning is more specific than "Protein Aggregates".
This graph shows the total number of publications written about "Protein Aggregates" by people in this website by year, and whether "Protein Aggregates" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2011 | 1 | 2 | 3 | | 2013 | 0 | 1 | 1 | | 2014 | 5 | 3 | 8 | | 2015 | 2 | 3 | 5 | | 2016 | 6 | 3 | 9 | | 2017 | 2 | 3 | 5 | | 2018 | 5 | 6 | 11 | | 2019 | 1 | 3 | 4 |
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Below are the most recent publications written about "Protein Aggregates" by people in Profiles.
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Schack MM, Dahl K, Rades T, Groenning M, Carpenter JF. Spectroscopic Evidence of Tertiary Structural Differences Between Insulin Molecules in Fibrils. J Pharm Sci. 2019 09; 108(9):2871-2879.
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Shea D, Hsu CC, Bi TM, Paranjapye N, Childers MC, Cochran J, Tomberlin CP, Wang L, Paris D, Zonderman J, Varani G, Link CD, Mullan M, Daggett V. a-Sheet secondary structure in amyloid ß-peptide drives aggregation and toxicity in Alzheimer's disease. Proc Natl Acad Sci U S A. 2019 04 30; 116(18):8895-8900.
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Riemslagh FW, Lans H, Seelaar H, Severijnen LWFM, Melhem S, Vermeulen W, Aronica E, Pasterkamp RJ, van Swieten JC, Willemsen R. HR23B pathology preferentially co-localizes with p62, pTDP-43 and poly-GA in C9ORF72-linked frontotemporal dementia and amyotrophic lateral sclerosis. Acta Neuropathol Commun. 2019 03 13; 7(1):39.
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Gandhi AV, Randolph TW, Carpenter JF. Conjugation of Emtansine Onto Trastuzumab Promotes Aggregation of the Antibody-Drug Conjugate by Reducing Repulsive Electrostatic Interactions and Increasing Hydrophobic Interactions. J Pharm Sci. 2019 06; 108(6):1973-1983.
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Collins LT, Otoupal PB, Campos JK, Courtney CM, Chatterjee A. Design of a De Novo Aggregating Antimicrobial Peptide and a Bacterial Conjugation-Based Delivery System. Biochemistry. 2019 03 19; 58(11):1521-1526.
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Wu H, Randolph TW. Rapid Quantification of Protein Particles in High-Concentration Antibody Formulations. J Pharm Sci. 2019 03; 108(3):1110-1116.
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Schack MM, Møller EH, Friderichsen AV, Carpenter JF, Rades T, Groenning M. Optimization of Infrared Microscopy to Assess Secondary Structure of Insulin Molecules Within Individual Subvisible Particles in Aqueous Formulations. J Pharm Sci. 2019 03; 108(3):1117-1129.
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Shah DD, Singh SM, Mallela KMG. Effect of Chemical Oxidation on the Higher Order Structure, Stability, Aggregation, and Biological Function of Interferon Alpha-2a: Role of Local Structural Changes Detected by 2D NMR. Pharm Res. 2018 Oct 15; 35(12):232.
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Shah DD, Zhang J, Hsieh MC, Sundaram S, Maity H, Mallela KMG. Effect of Peroxide- Versus Alkoxyl-Induced Chemical Oxidation on the Structure, Stability, Aggregation, and Function of a Therapeutic Monoclonal Antibody. J Pharm Sci. 2018 11; 107(11):2789-2803.
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Nejadnik MR, Randolph TW, Volkin DB, Schöneich C, Carpenter JF, Crommelin DJA, Jiskoot W. Postproduction Handling and Administration of Protein Pharmaceuticals and Potential Instability Issues. J Pharm Sci. 2018 08; 107(8):2013-2019.
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