 Anaphase-Promoting Complex-Cyclosome
"Anaphase-Promoting Complex-Cyclosome" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An E3 ubiquitin ligase primarily involved in regulation of the metaphase-to-anaphase transition during MITOSIS through ubiquitination of specific CELL CYCLE PROTEINS. Enzyme activity is tightly regulated through subunits and cofactors, which modulate activation, inhibition, and substrate specificity. The anaphase-promoting complex, or APC-C, is also involved in tissue differentiation in the PLACENTA, CRYSTALLINE LENS, and SKELETAL MUSCLE, and in regulation of postmitotic NEURONAL PLASTICITY and excitability.
| Descriptor ID |
D064173
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| MeSH Number(s) |
D08.811.464.938.750.092 D12.776.167.024
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Anaphase-Promoting Complex-Cyclosome".
Below are MeSH descriptors whose meaning is more specific than "Anaphase-Promoting Complex-Cyclosome".
- Anaphase-Promoting Complex-Cyclosome
- Apc1 Subunit, Anaphase-Promoting Complex-Cyclosome
- Apc10 Subunit, Anaphase-Promoting Complex-Cyclosome
- Apc11 Subunit, Anaphase-Promoting Complex-Cyclosome
- Apc2 Subunit, Anaphase-Promoting Complex-Cyclosome
- Apc3 Subunit, Anaphase-Promoting Complex-Cyclosome
- Apc4 Subunit, Anaphase-Promoting Complex-Cyclosome
- Apc5 Subunit, Anaphase-Promoting Complex-Cyclosome
- Apc6 Subunit, Anaphase-Promoting Complex-Cyclosome
- Apc7 Subunit, Anaphase-Promoting Complex-Cyclosome
- Apc8 Subunit, Anaphase-Promoting Complex-Cyclosome
- Cdc20 Proteins
- Cdh1 Proteins
This graph shows the total number of publications written about "Anaphase-Promoting Complex-Cyclosome" by people in this website by year, and whether "Anaphase-Promoting Complex-Cyclosome" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 0 | 2 | 2 | | 2005 | 0 | 1 | 1 | | 2016 | 2 | 0 | 2 | | 2017 | 0 | 1 | 1 |
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Below are the most recent publications written about "Anaphase-Promoting Complex-Cyclosome" by people in Profiles.
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Heasley LR, Markus SM, DeLuca JG. "Wait anaphase" signals are not confined to the mitotic spindle. Mol Biol Cell. 2017 May 01; 28(9):1186-1194.
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Choudhury R, Bonacci T, Arceci A, Lahiri D, Mills CA, Kernan JL, Branigan TB, DeCaprio JA, Burke DJ, Emanuele MJ. APC/C and SCF(cyclin F) Constitute a Reciprocal Feedback Circuit Controlling S-Phase Entry. Cell Rep. 2016 09 20; 16(12):3359-3372.
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Cappell SD, Chung M, Jaimovich A, Spencer SL, Meyer T. Irreversible APC(Cdh1) Inactivation Underlies the Point of No Return for Cell-Cycle Entry. Cell. 2016 Jun 30; 166(1):167-80.
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Yamamoto TM, Iwabuchi M, Ohsumi K, Kishimoto T. APC/C-Cdc20-mediated degradation of cyclin B participates in CSF arrest in unfertilized Xenopus eggs. Dev Biol. 2005 Mar 15; 279(2):345-55.
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Macdonald M, Wan Y, Wang W, Roberts E, Cheung TH, Erickson R, Knuesel MT, Liu X. Control of cell cycle-dependent degradation of c-Ski proto-oncoprotein by Cdc34. Oncogene. 2004 Jul 22; 23(33):5643-53.
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Wang W, Ungermannova D, Jin J, Harper JW, Liu X. Negative regulation of SCFSkp2 ubiquitin ligase by TGF-beta signaling. Oncogene. 2004 Feb 05; 23(5):1064-75.
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