 DNA Polymerase gamma
"DNA Polymerase gamma" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A DNA-directed DNA polymerase that functions in the replication of MITOCHONDRIAL DNA. Mutations in the gene that encodes this enzyme (POLG) are associated with some forms of OPHTHALMOPLEGIA, CHRONIC EXTERNAL PROGRESSIVE.
| Descriptor ID |
D000074002
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| MeSH Number(s) |
D08.811.913.696.445.308.300.169 D12.776.575.280
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| Concept/Terms |
DNA Polymerase gamma- DNA Polymerase gamma
- Polymerase gamma, DNA
- Mitochondrial DNA Polymerase
- DNA Polymerase, Mitochondrial
- Polymerase, Mitochondrial DNA
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Below are MeSH descriptors whose meaning is more general than "DNA Polymerase gamma".
Below are MeSH descriptors whose meaning is more specific than "DNA Polymerase gamma".
This graph shows the total number of publications written about "DNA Polymerase gamma" by people in this website by year, and whether "DNA Polymerase gamma" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 0 | 1 | 1 | | 2002 | 0 | 1 | 1 | | 2006 | 0 | 1 | 1 | | 2010 | 0 | 1 | 1 | | 2019 | 0 | 1 | 1 |
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Below are the most recent publications written about "DNA Polymerase gamma" by people in Profiles.
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Angione K, Eschbach K, Smith G, Joshi C, Demarest S. Genetic testing in a cohort of patients with potential epilepsy with myoclonic-atonic seizures. Epilepsy Res. 2019 02; 150:70-77.
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Kurt B, Jaeken J, Van Hove J, Lagae L, Löfgren A, Everman DB, Jayakar P, Naini A, Wierenga KJ, Van Goethem G, Copeland WC, DiMauro S. A novel POLG gene mutation in 4 children with Alpers-like hepatocerebral syndromes. Arch Neurol. 2010 Feb; 67(2):239-44.
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Lewis W, Day BJ, Kohler JJ, Hosseini SH, Chan SS, Green EC, Haase CP, Keebaugh ES, Long R, Ludaway T, Russ R, Steltzer J, Tioleco N, Santoianni R, Copeland WC. Decreased mtDNA, oxidative stress, cardiomyopathy, and death from transgenic cardiac targeted human mutant polymerase gamma. Lab Invest. 2007 Apr; 87(4):326-35.
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Graziewicz MA, Day BJ, Copeland WC. The mitochondrial DNA polymerase as a target of oxidative damage. Nucleic Acids Res. 2002 Jul 01; 30(13):2817-24.
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Richardson FC, Kuchta RD, Mazurkiewicz A, Richardson KA. Polymerization of 2'-fluoro- and 2'-O-methyl-dNTPs by human DNA polymerase alpha, polymerase gamma, and primase. Biochem Pharmacol. 2000 May 01; 59(9):1045-52.
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