 Poly (ADP-Ribose) Polymerase-1
"Poly (ADP-Ribose) Polymerase-1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A poly(ADP-ribose) polymerase that contains two ZINC FINGERS in its N-terminal DNA-binding region. It modifies NUCLEAR PROTEINS involved in chromatin architecture and BASE EXCISION REPAIR with POLY ADENOSINE DIPHOSPHATE RIBOSE.
| Descriptor ID |
D000071137
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| MeSH Number(s) |
D08.811.913.400.725.115.690.420
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| Concept/Terms |
Poly (ADP-Ribose) Polymerase-1- Poly (ADP-Ribose) Polymerase-1
- Poly (ADP-Ribose) Synthase-1
- PARP1 Protein
- PARP-1 Protein
- PARP 1 Protein
- NAD+ ADP-ribosyltransferase-1
- NAD+ ADP ribosyltransferase 1
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Below are MeSH descriptors whose meaning is more general than "Poly (ADP-Ribose) Polymerase-1".
Below are MeSH descriptors whose meaning is more specific than "Poly (ADP-Ribose) Polymerase-1".
This graph shows the total number of publications written about "Poly (ADP-Ribose) Polymerase-1" by people in this website by year, and whether "Poly (ADP-Ribose) Polymerase-1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 0 | 1 | 1 | | 2008 | 0 | 1 | 1 | | 2009 | 0 | 2 | 2 | | 2012 | 0 | 2 | 2 | | 2013 | 0 | 3 | 3 | | 2014 | 0 | 2 | 2 | | 2018 | 1 | 0 | 1 | | 2019 | 3 | 1 | 4 | | 2020 | 2 | 0 | 2 | | 2021 | 2 | 0 | 2 |
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Below are the most recent publications written about "Poly (ADP-Ribose) Polymerase-1" by people in Profiles.
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Li Z, Wang-Heaton H, Cartwright BM, Makinwa Y, Hilton BA, Musich PR, Shkriabai N, Kvaratskhelia M, Guan S, Chen Q, Yu X, Zou Y. ATR prevents Ca2+ overload-induced necrotic cell death through phosphorylation-mediated inactivation of PARP1 without DNA damage signaling. FASEB J. 2021 05; 35(5):e21373.
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Rudolph J, Roberts G, Luger K. Histone Parylation factor 1 contributes to the inhibition of PARP1 by cancer drugs. Nat Commun. 2021 02 02; 12(1):736.
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Frederick BA, Gupta R, Atilano-Roque A, Su TT, Raben D. Combined EGFR1 and PARP1 Inhibition Enhances the Effect of Radiation in Head and Neck Squamous Cell Carcinoma Models. Radiat Res. 2020 11 10; 194(5):519-531.
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Rudolph J, Mahadevan J, Luger K. Probing the Conformational Changes Associated with DNA Binding to PARP1. Biochemistry. 2020 06 02; 59(21):2003-2011.
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Nakamoto MY, Rudolph J, Wuttke DS, Luger K. Nonspecific Binding of RNA to PARP1 and PARP2 Does Not Lead to Catalytic Activation. Biochemistry. 2019 12 24; 58(51):5107-5111.
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Mahadevan J, Bowerman S, Luger K. Quantitating repair protein accumulation at DNA lesions: Past, present, and future. DNA Repair (Amst). 2019 09; 81:102650.
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Rudolph J, Luger K. Kinetics of DNA-protein association and dissociation by stopped-flow spectroscopy. Methods Enzymol. 2019; 625:135-156.
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Mahadevan J, Rudolph J, Jha A, Tay JW, Dragavon J, Grumstrup EM, Luger K. Q-FADD: A Mechanistic Approach for Modeling the Accumulation of Proteins at Sites of DNA Damage. Biophys J. 2019 06 04; 116(11):2224-2233.
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Rudolph J, Mahadevan J, Dyer P, Luger K. Poly(ADP-ribose) polymerase 1 searches DNA via a 'monkey bar' mechanism. Elife. 2018 08 08; 7.
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Muthurajan UM, Hepler MR, Hieb AR, Clark NJ, Kramer M, Yao T, Luger K. Automodification switches PARP-1 function from chromatin architectural protein to histone chaperone. Proc Natl Acad Sci U S A. 2014 Sep 02; 111(35):12752-7.
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