 Poly (ADP-Ribose) Polymerase-1
"Poly (ADP-Ribose) Polymerase-1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A poly(ADP-ribose) polymerase that contains two ZINC FINGERS in its N-terminal DNA-binding region. It modifies NUCLEAR PROTEINS involved in chromatin architecture and BASE EXCISION REPAIR with POLY ADENOSINE DIPHOSPHATE RIBOSE.
| Descriptor ID |
D000071137
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| MeSH Number(s) |
D08.811.913.400.725.115.690.420
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| Concept/Terms |
Poly (ADP-Ribose) Polymerase-1- Poly (ADP-Ribose) Polymerase-1
- Poly (ADP-Ribose) Synthase-1
- PARP1 Protein
- PARP-1 Protein
- PARP 1 Protein
- NAD+ ADP-ribosyltransferase-1
- NAD+ ADP ribosyltransferase 1
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Below are MeSH descriptors whose meaning is more general than "Poly (ADP-Ribose) Polymerase-1".
Below are MeSH descriptors whose meaning is more specific than "Poly (ADP-Ribose) Polymerase-1".
This graph shows the total number of publications written about "Poly (ADP-Ribose) Polymerase-1" by people in this website by year, and whether "Poly (ADP-Ribose) Polymerase-1" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2008 | 0 | 1 | 1 | | 2009 | 0 | 1 | 1 | | 2012 | 0 | 2 | 2 | | 2013 | 0 | 2 | 2 | | 2014 | 0 | 1 | 1 | | 2017 | 0 | 1 | 1 | | 2019 | 2 | 1 | 3 | | 2020 | 2 | 0 | 2 | | 2021 | 3 | 1 | 4 |
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Below are the most recent publications written about "Poly (ADP-Ribose) Polymerase-1" by people in Profiles.
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Rudolph J, Muthurajan UM, Palacio M, Mahadevan J, Roberts G, Erbse AH, Dyer PN, Luger K. The BRCT domain of PARP1 binds intact DNA and mediates intrastrand transfer. Mol Cell. 2021 12 16; 81(24):4994-5006.e5.
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Kotla S, Zhang A, Imanishi M, Ko KA, Lin SH, Gi YJ, Moczygemba M, Isgandarova S, Schadler KL, Chung C, Milgrom SA, Banchs J, Yusuf SW, Amaya DN, Guo H, Thomas TN, Shen YH, Deswal A, Herrmann J, Kleinerman ES, Entman ML, Cooke JP, Schifitto G, Maggirwar SB, McBeath E, Gupte AA, Krishnan S, Patel ZS, Yoon Y, Burks JK, Fujiwara K, Brookes PS, Le NT, Hamilton DJ, Abe JI. Nucleus-mitochondria positive feedback loop formed by ERK5 S496 phosphorylation-mediated poly (ADP-ribose) polymerase activation provokes persistent pro-inflammatory senescent phenotype and accelerates coronary atherosclerosis after chemo-radiation. Redox Biol. 2021 11; 47:102132.
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Li Z, Wang-Heaton H, Cartwright BM, Makinwa Y, Hilton BA, Musich PR, Shkriabai N, Kvaratskhelia M, Guan S, Chen Q, Yu X, Zou Y. ATR prevents Ca2+ overload-induced necrotic cell death through phosphorylation-mediated inactivation of PARP1 without DNA damage signaling. FASEB J. 2021 05; 35(5):e21373.
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Rudolph J, Roberts G, Luger K. Histone Parylation factor 1 contributes to the inhibition of PARP1 by cancer drugs. Nat Commun. 2021 02 02; 12(1):736.
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Frederick BA, Gupta R, Atilano-Roque A, Su TT, Raben D. Combined EGFR1 and PARP1 Inhibition Enhances the Effect of Radiation in Head and Neck Squamous Cell Carcinoma Models. Radiat Res. 2020 11 10; 194(5):519-531.
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Rudolph J, Mahadevan J, Luger K. Probing the Conformational Changes Associated with DNA Binding to PARP1. Biochemistry. 2020 06 02; 59(21):2003-2011.
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Mahadevan J, Bowerman S, Luger K. Quantitating repair protein accumulation at DNA lesions: Past, present, and future. DNA Repair (Amst). 2019 09; 81:102650.
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Rudolph J, Luger K. Kinetics of DNA-protein association and dissociation by stopped-flow spectroscopy. Methods Enzymol. 2019; 625:135-156.
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Mahadevan J, Rudolph J, Jha A, Tay JW, Dragavon J, Grumstrup EM, Luger K. Q-FADD: A Mechanistic Approach for Modeling the Accumulation of Proteins at Sites of DNA Damage. Biophys J. 2019 06 04; 116(11):2224-2233.
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Cimmino L, Dolgalev I, Wang Y, Yoshimi A, Martin GH, Wang J, Ng V, Xia B, Witkowski MT, Mitchell-Flack M, Grillo I, Bakogianni S, Ndiaye-Lobry D, MartÃn MT, Guillamot M, Banh RS, Xu M, Figueroa ME, Dickins RA, Abdel-Wahab O, Park CY, Tsirigos A, Neel BG, Aifantis I. Restoration of TET2 Function Blocks Aberrant Self-Renewal and Leukemia Progression. Cell. 2017 Sep 07; 170(6):1079-1095.e20.
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