 Riboswitch
"Riboswitch" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Part of a MESSENGER RNA molecule that undergoes a conformation change upon binding a specific metabolite or other small molecule thereby regulating the messenger RNA's transcription, post-transcriptional processing, transport, translation, or stability in response to varying levels of the metabolite or other small molecule.
| Descriptor ID |
D058928
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| MeSH Number(s) |
D13.444.735.544.427 D13.444.735.790.878.942.500 G02.111.570.080.689.687.124 G05.360.080.689.687.124
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Riboswitch".
Below are MeSH descriptors whose meaning is more specific than "Riboswitch".
This graph shows the total number of publications written about "Riboswitch" by people in this website by year, and whether "Riboswitch" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2011 | 5 | 0 | 5 | | 2012 | 5 | 1 | 6 | | 2013 | 3 | 0 | 3 | | 2014 | 5 | 0 | 5 | | 2015 | 5 | 2 | 7 | | 2016 | 3 | 0 | 3 | | 2017 | 7 | 1 | 8 | | 2018 | 7 | 1 | 8 | | 2019 | 3 | 0 | 3 | | 2020 | 4 | 2 | 6 |
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Below are the most recent publications written about "Riboswitch" by people in Profiles.
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Drogalis LK, Batey RT. Requirements for efficient ligand-gated co-transcriptional switching in designed variants of the B. subtilis pbuE adenine-responsive riboswitch in E. coli. PLoS One. 2020; 15(12):e0243155.
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Iwasaki RS, Batey RT. SPRINT: a Cas13a-based platform for detection of small molecules. Nucleic Acids Res. 2020 09 25; 48(17):e101.
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Sung HL, Nesbitt DJ. High pressure single-molecule FRET studies of the lysine riboswitch: cationic and osmolytic effects on pressure induced denaturation. Phys Chem Chem Phys. 2020 Jul 22; 22(28):15853-15866.
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Matyjasik MM, Hall SD, Batey RT. High Affinity Binding of N2-Modified Guanine Derivatives Significantly Disrupts the Ligand Binding Pocket of the Guanine Riboswitch. Molecules. 2020 May 13; 25(10).
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Miao Z, Adamiak RW, Antczak M, Boniecki MJ, Bujnicki J, Chen SJ, Cheng CY, Cheng Y, Chou FC, Das R, Dokholyan NV, Ding F, Geniesse C, Jiang Y, Joshi A, Krokhotin A, Magnus M, Mailhot O, Major F, Mann TH, Piatkowski P, Pluta R, Popenda M, Sarzynska J, Sun L, Szachniuk M, Tian S, Wang J, Wang J, Watkins AM, Wiedemann J, Xiao Y, Xu X, Yesselman JD, Zhang D, Zhang Y, Zhang Z, Zhao C, Zhao P, Zhou Y, Zok T, Zyla A, Ren A, Batey RT, Golden BL, Huang L, Lilley DM, Liu Y, Patel DJ, Westhof E. RNA-Puzzles Round IV: 3D structure predictions of four ribozymes and two aptamers. RNA. 2020 08; 26(8):982-995.
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Sherlock ME, Breaker RR. Former orphan riboswitches reveal unexplored areas of bacterial metabolism, signaling, and gene control processes. RNA. 2020 06; 26(6):675-693.
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Matyjasik MM, Batey RT. Structural basis for 2'-deoxyguanosine recognition by the 2'-dG-II class of riboswitches. Nucleic Acids Res. 2019 11 18; 47(20):10931-10941.
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Sung HL, Nesbitt DJ. Novel Heat-Promoted Folding Dynamics of the yybP-ykoY Manganese Riboswitch: Kinetic and Thermodynamic Studies at the Single-Molecule Level. J Phys Chem B. 2019 07 05; 123(26):5412-5422.
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Sung HL, Nesbitt DJ. Single-Molecule FRET Kinetics of the Mn2+ Riboswitch: Evidence for Allosteric Mg2+ Control of "Induced-Fit" vs "Conformational Selection" Folding Pathways. J Phys Chem B. 2019 03 07; 123(9):2005-2015.
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Polaski JT, Kletzien OA, Drogalis LK, Batey RT. A functional genetic screen reveals sequence preferences within a key tertiary interaction in cobalamin riboswitches required for ligand selectivity. Nucleic Acids Res. 2018 09 28; 46(17):9094-9105.
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