 Cytokine TWEAK
"Cytokine TWEAK" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A proteolytically-cleaved membrane glycoprotein and member of the TNF superfamily that is highly expressed in a variety of tissues including heart, pancreas, brain, and peripheral blood lymphocytes. The secreted extracellular form is a weak inducer of APOPTOSIS for some cell types and a ligand for the FN14 RECEPTOR. It mediates activation of NF-KAPPA-B and promotes ANGIOGENESIS and proliferation of ENDOTHELIAL CELLS, as well as expression of cytokines involved in INFLAMMATION.
| Descriptor ID |
D000074049
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| MeSH Number(s) |
D12.644.276.374.750.155 D12.776.467.374.750.155 D23.529.374.750.155
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| Concept/Terms |
Cytokine TWEAK- Cytokine TWEAK
- TWEAK, Cytokine
- TNF-Related Weak Inducer of Apoptosis
- TNF Related Weak Inducer of Apoptosis
- TWEAK Cytokine
- Cytokine, TWEAK
- Tumor Necrosis Factor Ligand Superfamily Member 12
- Apo3 Ligand
- Ligand, Apo3
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Below are MeSH descriptors whose meaning is more general than "Cytokine TWEAK".
Below are MeSH descriptors whose meaning is more specific than "Cytokine TWEAK".
This graph shows the total number of publications written about "Cytokine TWEAK" by people in this website by year, and whether "Cytokine TWEAK" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "Cytokine TWEAK" by people in Profiles.
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Holmberg R, Robinson M, Gilbert SF, Lujano-Olazaba O, Waters JA, Kogan E, Velasquez CLR, Stevenson D, Cruz LS, Alexander LJ, Lara J, Mu EM, Camillo JR, Bitler BG, Huxford T, House CD. TWEAK-Fn14-RelB Signaling Cascade Promotes Stem Cell-like Features that Contribute to Post-Chemotherapy Ovarian Cancer Relapse. Mol Cancer Res. 2023 02 01; 21(2):170-186.
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Iocca HA, Plant SR, Wang Y, Runkel L, O'Connor BP, Lundsmith ET, Hahm K, van Deventer HW, Burkly LC, Ting JP. TNF superfamily member TWEAK exacerbates inflammation and demyelination in the cuprizone-induced model. J Neuroimmunol. 2008 Feb; 194(1-2):97-106.
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