 Alpha-Ketoglutarate-Dependent Dioxygenase FTO
"Alpha-Ketoglutarate-Dependent Dioxygenase FTO" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A dioxygenase that repairs alkylated DNA and RNA by oxidative demethylation. It has highest activity towards single-stranded RNA containing 3-methyluracil, followed by SINGLE-STRANDED DNA containing 3-methylthymine and specifically demethylates N(6)-methyladenosine (m6A) RNA, the most common internal modification of MESSENGER RNA (mRNA) in higher EUKARYOTES. It contributes to the regulation of the global metabolic rate, energy HOMEOSTASIS, as well as body fat accumulation by regulating the differentiation of ADIPOCYTES into BROWN FAT CELLS or WHITE FAT CELLS.
| Descriptor ID |
D000071516
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| MeSH Number(s) |
D08.811.074.062.968 D08.811.682.662.582.242 D08.811.682.690.416.139.992
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| Concept/Terms |
Alpha-Ketoglutarate-Dependent Dioxygenase FTO- Alpha-Ketoglutarate-Dependent Dioxygenase FTO
- Alpha Ketoglutarate Dependent Dioxygenase FTO
- FTO, Alpha-Ketoglutarate-Dependent Dioxygenase
- Fat Mass and Obesity Associated (FTO) Protein
- Alpha-Ketoglutarate-Dependent Dioxygenase
- Alpha Ketoglutarate Dependent Dioxygenase
- Dioxygenase, Alpha-Ketoglutarate-Dependent
- Fat Mass and Obesity Associated Protein
- AlkB Homolog 9 Protein
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Below are MeSH descriptors whose meaning is more general than "Alpha-Ketoglutarate-Dependent Dioxygenase FTO".
Below are MeSH descriptors whose meaning is more specific than "Alpha-Ketoglutarate-Dependent Dioxygenase FTO".
This graph shows the total number of publications written about "Alpha-Ketoglutarate-Dependent Dioxygenase FTO" by people in this website by year, and whether "Alpha-Ketoglutarate-Dependent Dioxygenase FTO" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2008 | 0 | 1 | 1 | | 2010 | 0 | 2 | 2 | | 2013 | 0 | 3 | 3 | | 2014 | 0 | 1 | 1 | | 2016 | 0 | 1 | 1 | | 2017 | 1 | 0 | 1 | | 2018 | 2 | 0 | 2 | | 2020 | 0 | 2 | 2 |
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Below are the most recent publications written about "Alpha-Ketoglutarate-Dependent Dioxygenase FTO" by people in Profiles.
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Zhao X, Qiao D, Yang C, Kasela S, Kim W, Ma Y, Shrine N, Batini C, Sofer T, Taliun SAG, Sakornsakolpat P, Balte PP, Prokopenko D, Yu B, Lange LA, Dupuis J, Cade BE, Lee J, Gharib SA, Daya M, Laurie CA, Ruczinski I, Cupples LA, Loehr LR, Bartz TM, Morrison AC, Psaty BM, Vasan RS, Wilson JG, Taylor KD, Durda P, Johnson WC, Cornell E, Guo X, Liu Y, Tracy RP, Ardlie KG, Aguet F, VanDenBerg DJ, Papanicolaou GJ, Rotter JI, Barnes KC, Jain D, Nickerson DA, Muzny DM, Metcalf GA, Doddapaneni H, Dugan-Perez S, Gupta N, Gabriel S, Rich SS, O'Connor GT, Redline S, Reed RM, Laurie CC, Daviglus ML, Preudhomme LK, Burkart KM, Kaplan RC, Wain LV, Tobin MD, London SJ, Lappalainen T, Oelsner EC, Abecasis GR, Silverman EK, Barr RG, Cho MH, Manichaikul A. Whole genome sequence analysis of pulmonary function and COPD in 19,996 multi-ethnic participants. Nat Commun. 2020 10 14; 11(1):5182.
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Ontiveros RJ, Shen H, Stoute J, Yanas A, Cui Y, Zhang Y, Liu KF. Coordination of mRNA and tRNA methylations by TRMT10A. Proc Natl Acad Sci U S A. 2020 04 07; 117(14):7782-7791.
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Martin Carli JF, LeDuc CA, Zhang Y, Stratigopoulos G, Leibel RL. FTO mediates cell-autonomous effects on adipogenesis and adipocyte lipid content by regulating gene expression via 6mA DNA modifications. J Lipid Res. 2018 08; 59(8):1446-1460.
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Faulds KJ, Egelston JN, Sedivy LJ, Mitchell MK, Garimella S, Kozlowski H, D'Alessandro A, Hansen KC, Balsbaugh JL, Phiel CJ. Glycogen synthase kinase-3 (GSK-3) activity regulates mRNA methylation in mouse embryonic stem cells. J Biol Chem. 2018 07 06; 293(27):10731-10743.
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McCaffery JM, Jablonski KA, Franks PW, Delahanty LM, Aroda V, Marrero D, Hamman RF, Horton ES, Dagogo-Jack S, Wylie-Rosett J, Barrett-Connor E, Kitabchi A, Knowler WC, Wing RR, Florez JC. Replication of the Association of BDNF and MC4R Variants With Dietary Intake in the Diabetes Prevention Program. Psychosom Med. 2017 Feb/Mar; 79(2):224-233.
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Graff M, North KE, Richardson AS, Young KL, Mazul AL, Highland HM, Mohlke KL, Lange LA, Lange EM, Mullan Harris K, Gordon-Larsen P. BMI loci and longitudinal BMI from adolescence to young adulthood in an ethnically diverse cohort. Int J Obes (Lond). 2017 05; 41(5):759-768.
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Stratigopoulos G, Martin Carli JF, O'Day DR, Wang L, Leduc CA, Lanzano P, Chung WK, Rosenbaum M, Egli D, Doherty DA, Leibel RL. Hypomorphism for RPGRIP1L, a ciliary gene vicinal to the FTO locus, causes increased adiposity in mice. Cell Metab. 2014 May 06; 19(5):767-79.
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Bryan AD, Magnan RE, Hooper AE, Ciccolo JT, Marcus B, Hutchison KE. Colorado stride (COSTRIDE): testing genetic and physiological moderators of response to an intervention to increase physical activity. Int J Behav Nutr Phys Act. 2013 Dec 21; 10:139.
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Kumar R, Kohli S, Alam P, Barkotoky R, Gupta M, Tyagi S, Jain SK, Pasha MA. Interactions between the FTO and GNB3 genes contribute to varied clinical phenotypes in hypertension. PLoS One. 2013; 8(5):e63934.
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Richardson AS, North KE, Graff M, Young KM, Mohlke KL, Lange LA, Lange EM, Harris KM, Gordon-Larsen P. Moderate to vigorous physical activity interactions with genetic variants and body mass index in a large US ethnically diverse cohort. Pediatr Obes. 2014 Apr; 9(2):e35-46.
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