 Septins
"Septins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of GTP-binding proteins that were initially identified in YEASTS where they were shown to initiate the process of septation and bud formation. Septins form into hetero-oligomeric complexes that are comprised of several distinct septin subunits. These complexes can act as cytoskeletal elements that play important roles in CYTOKINESIS, cytoskeletal reorganization, BIOLOGICAL TRANSPORT, and membrane dynamics.
| Descriptor ID |
D058112
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| MeSH Number(s) |
D08.811.277.040.330.300.700 D12.776.157.325.757 D12.776.220.932
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Septins".
Below are MeSH descriptors whose meaning is more specific than "Septins".
This graph shows the total number of publications written about "Septins" by people in this website by year, and whether "Septins" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 0 | 1 | 1 | | 2008 | 0 | 1 | 1 | | 2010 | 1 | 0 | 1 | | 2011 | 3 | 0 | 3 | | 2013 | 1 | 0 | 1 | | 2014 | 3 | 0 | 3 | | 2015 | 2 | 0 | 2 | | 2016 | 4 | 0 | 4 | | 2017 | 1 | 0 | 1 | | 2018 | 2 | 0 | 2 | | 2019 | 2 | 0 | 2 | | 2020 | 2 | 1 | 3 |
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Below are the most recent publications written about "Septins" by people in Profiles.
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Heasley LR, Singer E, Cooperman BJ, McMurray MA. Saccharomyces spores are born prepolarized to outgrow away from spore-spore connections and penetrate the ascus wall. Yeast. 2021 01; 38(1):90-101.
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Spiliotis ET, McMurray MA. Masters of asymmetry - lessons and perspectives from 50 years of septins. Mol Biol Cell. 2020 10 01; 31(21):2289-2297.
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Johnson CR, Steingesser MG, Weems AD, Khan A, Gladfelter A, Bertin A, McMurray MA. Guanidine hydrochloride reactivates an ancient septin hetero-oligomer assembly pathway in budding yeast. Elife. 2020 01 28; 9.
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McMurray MA, Thorner J. Turning it inside out: The organization of human septin heterooligomers. Cytoskeleton (Hoboken). 2019 09; 76(9-10):449-456.
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McMurray MA. The long and short of membrane curvature sensing by septins. J Cell Biol. 2019 Apr 01; 218(4):1083-1085.
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Turner JA, Bemis JGT, Bagby SM, Capasso A, Yacob BW, Chimed TS, Van Gulick R, Lee H, Tobin R, Tentler JJ, Pitts T, McCarter M, Robinson WA, Couts KL. BRAF fusions identified in melanomas have variable treatment responses and phenotypes. Oncogene. 2019 02; 38(8):1296-1308.
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Provenzale D, Gupta S, Ahnen DJ, Markowitz AJ, Chung DC, Mayer RJ, Regenbogen SE, Blanco AM, Bray T, Cooper G, Early DS, Ford JM, Giardiello FM, Grady W, Hall MJ, Halverson AL, Hamilton SR, Hampel H, Klapman JB, Larson DW, Lazenby AJ, Llor X, Lynch PM, Mikkelson J, Ness RM, Slavin TP, Sugandha S, Weiss JM, Dwyer MA, Ogba N. NCCN Guidelines Insights: Colorectal Cancer Screening, Version 1.2018. J Natl Compr Canc Netw. 2018 08; 16(8):939-949.
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Barve G, Sridhar S, Aher A, Sahani MH, Chinchwadkar S, Singh S, K N L, McMurray MA, Manjithaya R. Septins are involved at the early stages of macroautophagy in S. cerevisiae. J Cell Sci. 2018 02 22; 131(4).
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Weems A, McMurray M. The step-wise pathway of septin hetero-octamer assembly in budding yeast. Elife. 2017 05 25; 6.
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Schaefer RM, Heasley LR, Odde DJ, McMurray MA. Kinetic partitioning during de novo septin filament assembly creates a critical G1 "window of opportunity" for mutant septin function. . 2016 Sep 16; 15(18):2441-53.
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