 Receptors, Enterotoxin
"Receptors, Enterotoxin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Guanylate cyclase-coupled receptors that bind bacterial ENTEROTOXINS, as well as the endogenous peptides guanylin and uroguanylin. Ligand binding stimulates production of CYCLIC GMP by EPITHELIAL CELLS of the intestinal lumen, altering barrier permeability and mucus secretion. Mutations in the gene (GUCY2C) encoding this receptor are associated with some cases of hereditary diarrhea (Diarrhea 6) and MECONIUM ILEUS.
| Descriptor ID |
D000074261
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| MeSH Number(s) |
D08.811.520.650.600.500.250 D12.776.543.750.700.250 D12.776.543.750.750.025
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| Concept/Terms |
Receptors, Enterotoxin- Receptors, Enterotoxin
- Enterotoxin-Guanylin Receptors
- Enterotoxin Guanylin Receptors
- Receptors, Enterotoxin-Guanylin
- Receptors, Guanyl Cyclase-C
- Receptors, Guanyl Cyclase C
- Guanyl Cyclase-C Receptors
- Cyclase-C Receptors, Guanyl
- Guanyl Cyclase C Receptors
- Guanylin-Uroguanylin Receptors
- Guanylin Uroguanylin Receptors
- Receptors, Guanylin-Uroguanylin
- Heat-Stable Enterotoxin Receptors
- Enterotoxin Receptors, Heat-Stable
- Heat Stable Enterotoxin Receptors
- Receptors, Heat-Stable Enterotoxin
- Enterotoxin Receptors
- GC-C Receptors
- GC C Receptors
- Receptors, GC-C
Enterotoxin Receptor- Enterotoxin Receptor
- Enterotoxin-Guanylin Receptor
- Enterotoxin Guanylin Receptor
- Receptor, Enterotoxin-Guanylin
- Guanyl Cyclase-C Receptor
- Guanyl Cyclase C Receptor
- Receptor, Guanyl Cyclase-C
- Receptor, Guanyl Cyclase C
- Guanylyl Cyclase C
- Cyclase C, Guanylyl
- Heat-Stable Enterotoxin Receptor
- Enterotoxin Receptor, Heat-Stable
- Heat Stable Enterotoxin Receptor
- Receptor, Heat-Stable Enterotoxin
- Receptor, Enterotoxin
- GC-C Receptor
- GC C Receptor
- Receptor, GC-C
- Guanylin-Uroguanylin Receptor
- Guanylin Uroguanylin Receptor
- Receptor, Guanylin-Uroguanylin
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Below are MeSH descriptors whose meaning is more general than "Receptors, Enterotoxin".
Below are MeSH descriptors whose meaning is more specific than "Receptors, Enterotoxin".
This graph shows the total number of publications written about "Receptors, Enterotoxin" by people in this website by year, and whether "Receptors, Enterotoxin" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 0 | 1 | 1 | | 2017 | 1 | 1 | 2 | | 2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "Receptors, Enterotoxin" by people in Profiles.
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Kim R, Leal AD, Parikh A, Ryan DP, Wang S, Bahamon B, Gupta N, Moss A, Pye J, Miao H, Inguilizian H, Cleary JM. A phase I, first-in-human study of TAK-164, an antibody-drug conjugate, in patients with advanced gastrointestinal cancers expressing guanylyl cyclase C. Cancer Chemother Pharmacol. 2023 04; 91(4):291-300.
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Almhanna K, Wright D, Mercade TM, Van Laethem JL, Gracian AC, Guillen-Ponce C, Faris J, Lopez CM, Hubner RA, Bendell J, Bols A, Feliu J, Starling N, Enzinger P, Mahalingham D, Messersmith W, Yang H, Fasanmade A, Danaee H, Kalebic T. A phase II study of antibody-drug conjugate, TAK-264 (MLN0264) in previously treated patients with advanced or metastatic pancreatic adenocarcinoma expressing guanylyl cyclase C. Invest New Drugs. 2017 10; 35(5):634-641.
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Almhanna K, Miron ML, Wright D, Gracian AC, Hubner RA, Van Laethem JL, L?pez CM, Alsina M, Mu?oz FL, Bendell J, Firdaus I, Messersmith W, Ye Z, Fasanmade AA, Danaee H, Kalebic T. Phase II study of the antibody-drug conjugate TAK-264 (MLN0264) in patients with metastatic or recurrent adenocarcinoma of the stomach or gastroesophageal junction expressing guanylyl cyclase C. Invest New Drugs. 2017 04; 35(2):235-241.
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Tucker CL, Ramamurthy V, Pina AL, Loyer M, Dharmaraj S, Li Y, Maumenee IH, Hurley JB, Koenekoop RK. Functional analyses of mutant recessive GUCY2D alleles identified in Leber congenital amaurosis patients: protein domain comparisons and dominant negative effects. Mol Vis. 2004 Apr 20; 10:297-303.
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