Heparin-binding EGF-like Growth Factor
"Heparin-binding EGF-like Growth Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An EGF family member that is expressed in a variety of hematopoietic, endothelial, vascular smooth muscle, and epithelial cells. It is synthesized as a transmembrane protein which is cleaved by proteases to produce the secreted form of the protein which has specificity for the EGF RECEPTOR and the ERBB-4 RECEPTOR. The membrane-bound form of the protein has been identified as the receptor which binds to and allows DIPHTHERIA TOXIN to enter cells.
Descriptor ID |
D066257
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MeSH Number(s) |
D12.644.276.382.625 D12.776.467.382.625 D23.529.382.625
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Concept/Terms |
Short Form HB-EGF- Short Form HB-EGF
- HB-EGF, Short Form
- Short Form HB EGF
- SF HB-EGF
- SF HB EGF
Heparin-binding Epidermal Growth Factor-like Growth Factor Precursor Protein- Heparin-binding Epidermal Growth Factor-like Growth Factor Precursor Protein
- Heparin binding Epidermal Growth Factor like Growth Factor Precursor Protein
- Receptor, Diphtheria Toxin
- HB-EGF Precursor
- HB EGF Precursor
- Diphtheria Toxin Receptor
- Toxin Receptor, Diphtheria
- Diphtheria Toxin Receptors
- Receptors, Diphtheria Toxin
- Toxin Receptors, Diphtheria
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Below are MeSH descriptors whose meaning is more general than "Heparin-binding EGF-like Growth Factor".
Below are MeSH descriptors whose meaning is more specific than "Heparin-binding EGF-like Growth Factor".
This graph shows the total number of publications written about "Heparin-binding EGF-like Growth Factor" by people in this website by year, and whether "Heparin-binding EGF-like Growth Factor" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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2009 | 0 | 1 | 1 | 2011 | 0 | 1 | 1 | 2012 | 0 | 1 | 1 | 2013 | 0 | 2 | 2 | 2015 | 1 | 0 | 1 | 2017 | 0 | 1 | 1 |
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Below are the most recent publications written about "Heparin-binding EGF-like Growth Factor" by people in Profiles.
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Haist KC, Burrack KS, Davenport BJ, Morrison TE. Inflammatory monocytes mediate control of acute alphavirus infection in mice. PLoS Pathog. 2017 12; 13(12):e1006748.
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Beswick DM, Santa Maria C, Ayoub NF, Capasso R, Santa Maria PL. Epithelial separation theory for post-tonsillectomy secondary hemorrhage: evidence in a mouse model and potential heparin-binding epidermal growth factor-like growth factor therapy. Eur Arch Otorhinolaryngol. 2018 Feb; 275(2):569-578.
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Johnson NR, Wang Y. Coacervate delivery of HB-EGF accelerates healing of type 2 diabetic wounds. Wound Repair Regen. 2015 Jul-Aug; 23(4):591-600.
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Yan F, Liu L, Dempsey PJ, Tsai YH, Raines EW, Wilson CL, Cao H, Cao Z, Liu L, Polk DB. A Lactobacillus rhamnosus GG-derived soluble protein, p40, stimulates ligand release from intestinal epithelial cells to transactivate epidermal growth factor receptor. J Biol Chem. 2013 Oct 18; 288(42):30742-30751.
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Rubtsov AV, Rubtsova K, Kappler JW, Marrack P. TLR7 drives accumulation of ABCs and autoantibody production in autoimmune-prone mice. Immunol Res. 2013 Mar; 55(1-3):210-6.
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Johnson NR, Wang Y. Controlled delivery of heparin-binding EGF-like growth factor yields fast and comprehensive wound healing. J Control Release. 2013 Mar 10; 166(2):124-9.
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Hilliard VC, Frey MR, Dempsey PJ, Peek RM, Polk DB. TNF-a converting enzyme-mediated ErbB4 transactivation by TNF promotes colonic epithelial cell survival. Am J Physiol Gastrointest Liver Physiol. 2011 Aug; 301(2):G338-46.
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Richardson GD, Bazzi H, Fantauzzo KA, Waters JM, Crawford H, Hynd P, Christiano AM, Jahoda CA. KGF and EGF signalling block hair follicle induction and promote interfollicular epidermal fate in developing mouse skin. Development. 2009 Jul; 136(13):2153-64.
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