 Polycomb Repressive Complex 2
"Polycomb Repressive Complex 2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A multisubunit polycomb protein complex that catalyzes the METHYLATION of chromosomal HISTONE H3. It works in conjunction with POLYCOMB REPRESSIVE COMPLEX 1 to effect EPIGENETIC REPRESSION.
| Descriptor ID |
D063151
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| MeSH Number(s) |
D05.500.781.750 D08.811.913.555.500.800.400.500 D12.776.660.235.600.200 D12.776.664.235.800.200 D12.776.930.780.890.200
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Polycomb Repressive Complex 2".
Below are MeSH descriptors whose meaning is more specific than "Polycomb Repressive Complex 2".
This graph shows the total number of publications written about "Polycomb Repressive Complex 2" by people in this website by year, and whether "Polycomb Repressive Complex 2" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 0 | 1 | 1 | | 2007 | 0 | 1 | 1 | | 2010 | 0 | 1 | 1 | | 2011 | 0 | 1 | 1 | | 2012 | 2 | 1 | 3 | | 2013 | 5 | 0 | 5 | | 2014 | 4 | 0 | 4 | | 2015 | 5 | 1 | 6 | | 2016 | 2 | 2 | 4 | | 2017 | 2 | 1 | 3 | | 2018 | 5 | 2 | 7 | | 2019 | 3 | 0 | 3 | | 2020 | 3 | 1 | 4 | | 2021 | 4 | 0 | 4 | | 2022 | 1 | 0 | 1 | | 2023 | 2 | 0 | 2 |
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Below are the most recent publications written about "Polycomb Repressive Complex 2" by people in Profiles.
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Song J, Gooding AR, Hemphill WO, Love BD, Robertson A, Yao L, Zon LI, North TE, Kasinath V, Cech TR. Structural basis for inactivation of PRC2 by G-quadruplex RNA. Science. 2023 09 22; 381(6664):1331-1337.
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Hemphill WO, Fenske R, Gooding AR, Cech TR. PRC2 direct transfer from G-quadruplex RNA to dsDNA has implications for RNA-binding chromatin modifiers. Proc Natl Acad Sci U S A. 2023 06 06; 120(23):e2220528120.
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Kraft K, Yost KE, Murphy SE, Magg A, Long Y, Corces MR, Granja JM, Wittler L, Mundlos S, Cech TR, Boettiger AN, Chang HY. Polycomb-mediated genome architecture enables long-range spreading of H3K27 methylation. Proc Natl Acad Sci U S A. 2022 05 31; 119(22):e2201883119.
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Iragavarapu AG, Yao L, Kasinath V. Structural insights into the interactions of Polycomb Repressive Complex 2 with chromatin. Biochem Soc Trans. 2021 12 17; 49(6):2639-2653.
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Brown K, Andrianakos H, Ingersoll S, Ren X. Single-molecule imaging of epigenetic complexes in living cells: insights from studies on Polycomb group proteins. Nucleic Acids Res. 2021 07 09; 49(12):6621-6637.
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Soto RA, Najia MAT, Hachimi M, Frame JM, Yette GA, Lummertz da Rocha E, Stankunas K, Daley GQ, North TE. Sequential regulation of hemogenic fate and hematopoietic stem and progenitor cell formation from arterial endothelium by Ezh1/2. Stem Cell Reports. 2021 07 13; 16(7):1718-1734.
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Kasinath V, Beck C, Sauer P, Poepsel S, Kosmatka J, Faini M, Toso D, Aebersold R, Nogales E. JARID2 and AEBP2 regulate PRC2 in the presence of H2AK119ub1 and other histone modifications. Science. 2021 01 22; 371(6527).
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Youmans DT, Gooding AR, Dowell RD, Cech TR. Competition between PRC2.1 and 2.2 subcomplexes regulates PRC2 chromatin occupancy in human stem cells. Mol Cell. 2021 02 04; 81(3):488-501.e9.
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Fang H, Bonora G, Lewandowski JP, Thakur J, Filippova GN, Henikoff S, Shendure J, Duan Z, Rinn JL, Deng X, Noble WS, Disteche CM. Trans- and cis-acting effects of Firre on epigenetic features of the inactive X chromosome. Nat Commun. 2020 11 27; 11(1):6053.
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Long Y, Hwang T, Gooding AR, Goodrich KJ, Rinn JL, Cech TR. RNA is essential for PRC2 chromatin occupancy and function in human pluripotent stem cells. Nat Genet. 2020 09; 52(9):931-938.
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