 Polycomb Repressive Complex 1
"Polycomb Repressive Complex 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A multisubunit polycomb protein complex with affinity for CHROMATIN that contains methylated HISTONE H3. It contains an E3 ubiquitin ligase activity that is specific for HISTONE H2A and works in conjunction with POLYCOMB REPRESSIVE COMPLEX 2 to effect EPIGENETIC REPRESSION.
| Descriptor ID |
D063150
|
| MeSH Number(s) |
D05.500.781.100 D08.811.464.938.750.280 D12.776.660.235.600.100 D12.776.664.235.800.100 D12.776.930.780.890.100
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Polycomb Repressive Complex 1".
Below are MeSH descriptors whose meaning is more specific than "Polycomb Repressive Complex 1".
This graph shows the total number of publications written about "Polycomb Repressive Complex 1" by people in this website by year, and whether "Polycomb Repressive Complex 1" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2010 | 0 | 2 | 2 | | 2011 | 0 | 1 | 1 | | 2012 | 1 | 0 | 1 | | 2014 | 1 | 0 | 1 | | 2015 | 0 | 2 | 2 | | 2016 | 3 | 1 | 4 | | 2017 | 1 | 0 | 1 | | 2018 | 3 | 1 | 4 | | 2019 | 2 | 0 | 2 | | 2020 | 1 | 0 | 1 | | 2021 | 1 | 0 | 1 | | 2023 | 2 | 0 | 2 | | 2024 | 1 | 1 | 2 | | 2025 | 0 | 1 | 1 | | 2026 | 1 | 2 | 3 |
To return to the timeline, click here.
Below are the most recent publications written about "Polycomb Repressive Complex 1" by people in Profiles.
-
Ingersoll S, Trouth A, Angel JC, Luo X, Espinoza A, Wen J, Zhu C, Tucker J, Astatike K, Phiel CJ, Sabaawy H, Kutateladze TG, Wu TP, Yao T, Lu C, Ramachandran S, Ren X. Self-clustering of three CBX2 molecules drives PRC2 to promote facultative heterochromatinization of Polycomb target genes. Mol Cell. 2026 Mar 19; 86(6):1015-1031.e16.
-
Rosas R, Baracaldo-Lancheros LF, Dykhuizen EC, Musselman CA. Structural landscape of H3K27me3 recognition by protein domains and their potential for inhibition. J Biol Chem. 2026 Apr; 302(4):111344.
-
Sirohi K, Sripada A, Verma M, Varma R, Liu S, Yadav S, Sahu A, Manka L, Guntur VP, Gorska MM, Alam R. CBX7 functions as a methylation-dependent inducer of gene transcription and regulator of cytosolic signaling in lymphoid cells. Sci Adv. 2026 Feb 13; 12(7):eadj4926.
-
Marunde MR, Popova IK, Hall NW, Vaidya A, Bone JR, Boone BA, Brown PJ, Ezell RJ, Firestone TM, Fuchs HA, Gibson E, Gillespie ZB, Gloor SL, Hickman AR, Howard SA, Husby NL, Hsiung VT, Johnstone AL, Khan LF, Krajewski K, Lee AS, McAnarney ET, Maier KE, Maryanski DN, McCuiston JL, Noll KE, Novitzky K, Patteson EF, Rodriguez KL, Sanchez JC, Schachner LF, Smith CE, Sun L, Taylor HF, Watson R, Willis HE, Musselman CA, Venters BJ, Cheek MA, Meiners MJ, Sun ZW, Kelleher NL, Cowles MW, Weinzapfel EN, Keogh MC, Burg JM. Nucleosome context regulates chromatin reader preference. Nucleic Acids Res. 2025 Oct 28; 53(20).
-
Iwanaga R, Yamamoto TM, Gomez K, Nguyen LL, Woodruff ER, Post MD, Mikeska RG, Danis E, Danhorn T, Boorgula MP, Mitra SS, Marjon NA, Bitler BG, Brubaker LW. Tumor-Intrinsic Activity of Chromobox 2 Remodels the Tumor Microenvironment in High-grade Serous Carcinoma. Cancer Res Commun. 2024 08 01; 4(8):1919-1932.
-
Floyd J, DeSanto K, Bitler BG, Brubaker LW. Polycomb Repressor Complex 1 (PRC1) in ovarian cancer: A scoping literature review. Crit Rev Oncol Hematol. 2024 Oct; 202:104456.
-
Brown K, Chew PY, Ingersoll S, Espinosa JR, Aguirre A, Espinoza A, Wen J, Astatike K, Kutateladze TG, Collepardo-Guevara R, Ren X. Principles of assembly and regulation of condensates of Polycomb repressive complex 1 through phase separation. Cell Rep. 2023 10 31; 42(10):113136.
-
Brubaker LW, Backos DS, Nguyen VT, Reigan P, Yamamoto TM, Woodruff ER, Iwanaga R, Wempe MF, Kumar V, Persenaire C, Watson ZL, Bitler BG. Novel chromobox 2 inhibitory peptide decreases tumor progression. Expert Opin Ther Targets. 2023 Apr-May; 27(4-5):361-371.
-
Suh JL, Bsteh D, Hart B, Si Y, Weaver TM, Pribitzer C, Lau R, Soni S, Ogana H, Rectenwald JM, Norris JL, Cholensky SH, Sagum C, Umana JD, Li D, Hardy B, Bedford MT, Mumenthaler SM, Lenz HJ, Kim YM, Wang GG, Pearce KH, James LI, Kireev DB, Musselman CA, Frye SV, Bell O. Reprogramming CBX8-PRC1 function with a positive allosteric modulator. Cell Chem Biol. 2022 04 21; 29(4):555-571.e11.
-
Brown K, Andrianakos H, Ingersoll S, Ren X. Single-molecule imaging of epigenetic complexes in living cells: insights from studies on Polycomb group proteins. Nucleic Acids Res. 2021 07 09; 49(12):6621-6637.
|
People  People who have written about this concept. _
Similar Concepts
People who have written about this concept.
_
Top Journals
Top journals in which articles about this concept have been published.
|