 CCCTC-Binding Factor
"CCCTC-Binding Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A repressor protein with poly(ADP)-ribose binding activity that binds CHROMATIN and DNA; its structure consisting of 11 CYS2-HIS2 ZINC FINGERS allows it to recognize many different DNA target sites. It functions as a repressor by binding to INSULATOR ELEMENTS and preventing interaction between promoters and nearby enhancers and silencers. It plays a critical role in EPIGENETIC PROCESSES, including GENOMIC IMPRINTING.
| Descriptor ID |
D000076246
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| MeSH Number(s) |
D12.776.157.687.157 D12.776.260.120 D12.776.660.235.050 D12.776.660.720.157 D12.776.664.235.050 D12.776.930.780.563
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| Concept/Terms |
CCCTC-Binding Factor- CCCTC-Binding Factor
- CCCTC Binding Factor
- DNA-Binding Protein CTCF
- CTCF, DNA-Binding Protein
- DNA Binding Protein CTCF
- CTCF Protein
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Below are MeSH descriptors whose meaning is more general than "CCCTC-Binding Factor".
Below are MeSH descriptors whose meaning is more specific than "CCCTC-Binding Factor".
This graph shows the total number of publications written about "CCCTC-Binding Factor" by people in this website by year, and whether "CCCTC-Binding Factor" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 0 | 1 | 1 | | 2009 | 0 | 1 | 1 | | 2010 | 0 | 2 | 2 | | 2011 | 0 | 1 | 1 | | 2017 | 0 | 1 | 1 | | 2018 | 3 | 0 | 3 |
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Below are the most recent publications written about "CCCTC-Binding Factor" by people in Profiles.
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Maass PG, Barutcu AR, Rinn JL. Interchromosomal interactions: A genomic love story of kissing chromosomes. J Cell Biol. 2019 01 07; 218(1):27-38.
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Washington SD, Edenfield SI, Lieux C, Watson ZL, Taasan SM, Dhummakupt A, Bloom DC, Neumann DM. Depletion of the Insulator Protein CTCF Results in Herpes Simplex Virus 1 Reactivation In Vivo. J Virol. 2018 06 01; 92(11).
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Barutcu AR, Maass PG, Lewandowski JP, Weiner CL, Rinn JL. A TAD boundary is preserved upon deletion of the CTCF-rich Firre locus. Nat Commun. 2018 04 13; 9(1):1444.
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Modrek AS, Golub D, Khan T, Bready D, Prado J, Bowman C, Deng J, Zhang G, Rocha PP, Raviram R, Lazaris C, Stafford JM, LeRoy G, Kader M, Dhaliwal J, Bayin NS, Frenster JD, Serrano J, Chiriboga L, Baitalmal R, Nanjangud G, Chi AS, Golfinos JG, Wang J, Karajannis MA, Bonneau RA, Reinberg D, Tsirigos A, Zagzag D, Snuderl M, Skok JA, Neubert TA, Placantonakis DG. Low-Grade Astrocytoma Mutations in IDH1, P53, and ATRX Cooperate to Block Differentiation of Human Neural Stem Cells via Repression of SOX2. Cell Rep. 2017 Oct 31; 21(5):1267-1280.
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Schuyler RP, Merkel A, Raineri E, Altucci L, Vellenga E, Martens JHA, Pourfarzad F, Kuijpers TW, Burden F, Farrow S, Downes K, Ouwehand WH, Clarke L, Datta A, Lowy E, Flicek P, Frontini M, Stunnenberg HG, MartÃn-Subero JI, Gut I, Heath S. Distinct Trends of DNA Methylation Patterning in the Innate and Adaptive Immune Systems. Cell Rep. 2016 11 15; 17(8):2101-2111.
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Gillen AE, Harris A. The role of CTCF in coordinating the expression of single gene loci. Biochem Cell Biol. 2011 Oct; 89(5):489-94.
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Gomes NP, Espinosa JM. Disparate chromatin landscapes and kinetics of inactivation impact differential regulation of p53 target genes. . 2010 Sep 01; 9(17):3428-37.
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Gomes NP, Espinosa JM. Gene-specific repression of the p53 target gene PUMA via intragenic CTCF-Cohesin binding. Genes Dev. 2010 May 15; 24(10):1022-34.
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Blackledge NP, Ott CJ, Gillen AE, Harris A. An insulator element 3' to the CFTR gene binds CTCF and reveals an active chromatin hub in primary cells. Nucleic Acids Res. 2009 Mar; 37(4):1086-94.
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Mukhopadhyay R, Yu W, Whitehead J, Xu J, Lezcano M, Pack S, Kanduri C, Kanduri M, Ginjala V, Vostrov A, Quitschke W, Chernukhin I, Klenova E, Lobanenkov V, Ohlsson R. The binding sites for the chromatin insulator protein CTCF map to DNA methylation-free domains genome-wide. Genome Res. 2004 Aug; 14(8):1594-602.
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