 Homer Scaffolding Proteins
"Homer Scaffolding Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Homer proteins belong to a family of adaptor and scaffold proteins which include Homer1, Homer2 and Homer3. Homer1 and Homer2 play a role in the regulation of calcium homeostasis, whereas Homer3 functions in stimulating changes in actin dynamics in neurons and T-cells. Homer proteins are best known as scaffold proteins at the post-synaptic density where they facilitate synaptic signaling. They function as a molecular switch in metabotropic glutamate receptor (MGluR) signaling, and are associated with human Fragile X syndrome.
| Descriptor ID |
D000072233
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| MeSH Number(s) |
D12.776.476.024.381
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| Concept/Terms |
Homer Scaffolding Proteins- Homer Scaffolding Proteins
- Proteins, Homer Scaffolding
- Scaffolding Proteins, Homer
- Homer Proteins
- Proteins, Homer
Homer 1C- Homer 1C
- Homer 1C Proteins
- Proteins, Homer 1C
Homer 3- Homer 3
- Homer 3 Proteins
- Proteins, Homer 3
Homer 2- Homer 2
- Homer 2 Proteins
- Proteins, Homer 2
Homer 1a- Homer 1a
- Homer 1 Proteins
- Proteins, Homer 1
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Below are MeSH descriptors whose meaning is more general than "Homer Scaffolding Proteins".
Below are MeSH descriptors whose meaning is more specific than "Homer Scaffolding Proteins".
This graph shows the total number of publications written about "Homer Scaffolding Proteins" by people in this website by year, and whether "Homer Scaffolding Proteins" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 0 | 3 | 3 | | 2006 | 0 | 1 | 1 | | 2009 | 0 | 1 | 1 |
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Below are the most recent publications written about "Homer Scaffolding Proteins" by people in Profiles.
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Ploense KL, Li X, Baker-Andresen D, Carr AE, Woodward N, Bagley J, Szumlinski KK, Bredy TW, Kippin TE. Prolonged-access to cocaine induces distinct Homer2 DNA methylation, hydroxymethylation, and transcriptional profiles in the dorsomedial prefrontal cortex of Male Sprague-Dawley rats. Neuropharmacology. 2018 12; 143:299-305.
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Ploense KL, Vieira P, Bubalo L, Olivarria G, Carr AE, Szumlinski KK, Kippin TE. Contributions of prolonged contingent and non-contingent cocaine exposure to escalation of cocaine intake and glutamatergic gene expression. Psychopharmacology (Berl). 2018 05; 235(5):1347-1359.
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Saddoris MP, Holland PC, Gallagher M. Associatively learned representations of taste outcomes activate taste-encoding neural ensembles in gustatory cortex. J Neurosci. 2009 Dec 09; 29(49):15386-96.
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Szumlinski KK, Abernathy KE, Oleson EB, Klugmann M, Lominac KD, He DY, Ron D, During M, Kalivas PW. Homer isoforms differentially regulate cocaine-induced neuroplasticity. Neuropsychopharmacology. 2006 Apr; 31(4):768-77.
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Lominac KD, Oleson EB, Pava M, Klugmann M, Schwarz MK, Seeburg PH, During MJ, Worley PF, Kalivas PW, Szumlinski KK. Distinct roles for different Homer1 isoforms in behaviors and associated prefrontal cortex function. J Neurosci. 2005 Dec 14; 25(50):11586-94.
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Szumlinski KK, Lominac KD, Oleson EB, Walker JK, Mason A, Dehoff MH, Klugmann M, Klugman M, Cagle S, Welt K, During M, Worley PF, Middaugh LD, Kalivas PW. Homer2 is necessary for EtOH-induced neuroplasticity. J Neurosci. 2005 Jul 27; 25(30):7054-61.
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Szumlinski KK, Lominac KD, Kleschen MJ, Oleson EB, Dehoff MH, Schwarz MK, Schwartz MK, Seeburg PH, Seeberg PH, Worley PF, Kalivas PW. Behavioral and neurochemical phenotyping of Homer1 mutant mice: possible relevance to schizophrenia. Genes Brain Behav. 2005 Jul; 4(5):273-88.
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