NF-KappaB Inhibitor alpha
"NF-KappaB Inhibitor alpha" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An I-kappa B protein that inhibits the activity of dimeric NF-KAPPA B P50-REL complexes, sequesters transcription factor NF-kappaB as an inactive complex in the cytoplasm; and prevents NF-kappaB nuclear translocation and DNA binding.
Descriptor ID |
D000072000
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MeSH Number(s) |
D12.644.360.365.500 D12.776.260.420.500 D12.776.476.381.500 D12.776.930.326.500
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Concept/Terms |
NF-KappaB Inhibitor alpha- NF-KappaB Inhibitor alpha
- Inhibitor alpha, NF-KappaB
- NF KappaB Inhibitor alpha
- alpha, NF-KappaB Inhibitor
- Major Histocompatibility Complex Enhancer-Binding Protein MAD3
- Major Histocompatibility Complex Enhancer Binding Protein MAD3
- IKappaB-alpha
- IKappaB alpha
- p40 Protein (IKappaB-alpha)
- I Kappa B-alpha Protein
- I Kappa B alpha Protein
- IKappaBalpha
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Below are MeSH descriptors whose meaning is more general than "NF-KappaB Inhibitor alpha".
Below are MeSH descriptors whose meaning is more specific than "NF-KappaB Inhibitor alpha".
This graph shows the total number of publications written about "NF-KappaB Inhibitor alpha" by people in this website by year, and whether "NF-KappaB Inhibitor alpha" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
Year | Major Topic | Minor Topic | Total |
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1995 | 0 | 2 | 2 | 1996 | 0 | 2 | 2 | 1997 | 0 | 1 | 1 | 1998 | 0 | 2 | 2 | 1999 | 0 | 2 | 2 | 2000 | 0 | 1 | 1 | 2001 | 0 | 1 | 1 | 2002 | 0 | 3 | 3 | 2003 | 0 | 2 | 2 | 2004 | 0 | 2 | 2 | 2005 | 0 | 3 | 3 | 2006 | 0 | 3 | 3 | 2008 | 0 | 2 | 2 | 2009 | 0 | 4 | 4 | 2010 | 0 | 1 | 1 | 2011 | 0 | 1 | 1 | 2012 | 0 | 1 | 1 | 2013 | 0 | 2 | 2 | 2014 | 0 | 1 | 1 | 2018 | 0 | 1 | 1 | 2020 | 0 | 2 | 2 |
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Below are the most recent publications written about "NF-KappaB Inhibitor alpha" by people in Profiles.
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Gu VW, Cho E, Thompson DT, Cassady VC, Borcherding N, Koch KE, Wu VT, Lorenzen AW, van der Heide DM, White JR, Kulak MV, Williams T, Zhang W, Weigel RJ. AP-2? Is Required for Maintenance of Multipotent Mammary Stem Cells. Stem Cell Reports. 2021 01 12; 16(1):106-119.
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Wright CJ, Cari EL, Sandoval J, Bales E, Sam PK, Zarate MA, Polotsky AJ, Kallen AN, Johnson J. Control of Murine Primordial Follicle Growth Activation by I?B/NF?B Signaling. Reprod Sci. 2020 11; 27(11):2063-2074.
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Chen S, Bonifati S, Qin Z, St Gelais C, Kodigepalli KM, Barrett BS, Kim SH, Antonucci JM, Ladner KJ, Buzovetsky O, Knecht KM, Xiong Y, Yount JS, Guttridge DC, Santiago ML, Wu L. SAMHD1 suppresses innate immune responses to viral infections and inflammatory stimuli by inhibiting the NF-?B and interferon pathways. Proc Natl Acad Sci U S A. 2018 04 17; 115(16):E3798-E3807.
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Petersheim D, Massaad MJ, Lee S, Scarselli A, Cancrini C, Moriya K, Sasahara Y, Lankester AC, Dorsey M, Di Giovanni D, Bezrodnik L, Ohnishi H, Nishikomori R, Tanita K, Kanegane H, Morio T, Gelfand EW, Jain A, Secord E, Picard C, Casanova JL, Albert MH, Torgerson TR, Geha RS. Mechanisms of genotype-phenotype correlation in autosomal dominant anhidrotic ectodermal dysplasia with immune deficiency. J Allergy Clin Immunol. 2018 03; 141(3):1060-1073.e3.
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Bauerle KT, Schweppe RE, Lund G, Kotnis G, Deep G, Agarwal R, Pozdeyev N, Wood WM, Haugen BR. Nuclear factor ?B-dependent regulation of angiogenesis, and metastasis in an in vivo model of thyroid cancer is associated with secreted interleukin-8. J Clin Endocrinol Metab. 2014 Aug; 99(8):E1436-44.
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Lockett AD, Kimani S, Ddungu G, Wrenger S, Tuder RM, Janciauskiene SM, Petrache I. a1-Antitrypsin modulates lung endothelial cell inflammatory responses to TNF-a. Am J Respir Cell Mol Biol. 2013 Jul; 49(1):143-50.
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Tang JR, Michaelis KA, Nozik-Grayck E, Seedorf GJ, Hartman-Filson M, Abman SH, Wright CJ. The NF-?B inhibitory proteins I?Ba and I?B? mediate disparate responses to inflammation in fetal pulmonary endothelial cells. J Immunol. 2013 Mar 15; 190(6):2913-23.
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Koga H, Hagiwara S, Inomata M, Kono Y, Oyama Y, Kai S, Nishida T, Noguchi T. The new vitamin E derivative, ETS-GS, protects against cecal ligation and puncture-induced systemic inflammation in rats. Inflammation. 2012 Apr; 35(2):545-53.
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Wu Y, Lousberg EL, Moldenhauer LM, Hayball JD, Coller JK, Rice KC, Watkins LR, Somogyi AA, Hutchinson MR. Inhibiting the TLR4-MyD88 signalling cascade by genetic or pharmacological strategies reduces acute alcohol-induced sedation and motor impairment in mice. Br J Pharmacol. 2012 Mar; 165(5):1319-29.
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Zhou X, Shapiro L, Fellingham G, Willardson BM, Burton GF. HIV replication in CD4+ T lymphocytes in the presence and absence of follicular dendritic cells: inhibition of replication mediated by a-1-antitrypsin through altered I?Ba ubiquitination. J Immunol. 2011 Mar 01; 186(5):3148-55.
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