 Forkhead Box Protein O1
"Forkhead Box Protein O1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A forkhead box transcription factor that is a major target of INSULIN signaling and regulator of metabolic homeostasis in response to OXIDATIVE STRESS. It binds to the insulin RESPONSE ELEMENT (IRE) and the related Daf-16 family binding element (DBE). Its activity is suppressed by insulin and it also regulates OSTEOBLAST proliferation, controls bone mass, and skeletal regulation of GLUCOSE metabolism. It promotes GLUCONEOGENESIS in HEPATOCYTES and regulates gene expression in ADIPOSE TISSUE. It is also an important CELL DEATH regulator. Chromosomal aberrations involving the FOXO1 gene occur in RHABDOMYOSARCOMA.
| Descriptor ID |
D000071161
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| MeSH Number(s) |
D12.776.260.950.249.250 D12.776.930.977.249.250
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Forkhead Box Protein O1".
Below are MeSH descriptors whose meaning is more specific than "Forkhead Box Protein O1".
This graph shows the total number of publications written about "Forkhead Box Protein O1" by people in this website by year, and whether "Forkhead Box Protein O1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 1 | 1 | | 2006 | 0 | 1 | 1 | | 2010 | 0 | 1 | 1 | | 2011 | 0 | 1 | 1 | | 2012 | 0 | 2 | 2 | | 2014 | 0 | 1 | 1 | | 2017 | 0 | 2 | 2 | | 2018 | 0 | 1 | 1 | | 2019 | 0 | 1 | 1 |
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Below are the most recent publications written about "Forkhead Box Protein O1" by people in Profiles.
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Fettig LM, Sartorius CA. Phospho-PR Isoforms and Cancer Stem Cells: What Does the FOXO1 Say? Endocrinology. 2019 05 01; 160(5):1067-1068.
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Zurlo G, Piquereau J, Moulin M, Pires Da Silva J, Gressette M, Ranchoux B, Garnier A, Ventura-Clapier R, Fadel E, Humbert M, Lemaire C, Perros F, Veksler V. Sirtuin 1 regulates pulmonary artery smooth muscle cell proliferation: role in pulmonary arterial hypertension. J Hypertens. 2018 05; 36(5):1164-1177.
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Camden AJ, Szwarc MM, Chadchan SB, DeMayo FJ, O'Malley BW, Lydon JP, Kommagani R. Growth regulation by estrogen in breast cancer 1 (GREB1) is a novel progesterone-responsive gene required for human endometrial stromal decidualization. Mol Hum Reprod. 2017 09 01; 23(9):646-653.
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Irimia JM, Meyer CM, Segvich DM, Surendran S, DePaoli-Roach AA, Morral N, Roach PJ. Lack of liver glycogen causes hepatic insulin resistance and steatosis in mice. J Biol Chem. 2017 06 23; 292(25):10455-10464.
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Gays D, Hess C, Camporeale A, Ala U, Provero P, Mosimann C, Santoro MM. An exclusive cellular and molecular network governs intestinal smooth muscle cell differentiation in vertebrates. Development. 2017 02 01; 144(3):464-478.
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Saben JL, Asghar Z, Rhee JS, Drury A, Scheaffer S, Moley KH. Excess Maternal Fructose Consumption Increases Fetal Loss and Impairs Endometrial Decidualization in Mice. Endocrinology. 2016 Feb; 157(2):956-68.
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Lu Y, Wu Y, Feng X, Shen R, Wang JH, Fallahi M, Li W, Yang C, Hankey W, Zhao W, Ganju RK, Li MO, Cleveland JL, Zou X. CDK4 deficiency promotes genomic instability and enhances Myc-driven lymphomagenesis. J Clin Invest. 2014 Apr; 124(4):1672-84.
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Kikuchi K, Hettmer S, Aslam MI, Michalek JE, Laub W, Wilky BA, Loeb DM, Rubin BP, Wagers AJ, Keller C. Cell-cycle dependent expression of a translocation-mediated fusion oncogene mediates checkpoint adaptation in rhabdomyosarcoma. PLoS Genet. 2014 Jan; 10(1):e1004107.
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Talchai C, Xuan S, Lin HV, Sussel L, Accili D. Pancreatic ß cell dedifferentiation as a mechanism of diabetic ß cell failure. Cell. 2012 Sep 14; 150(6):1223-34.
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Qadri I, Choudhury M, Rahman SM, Knotts TA, Janssen RC, Schaack J, Iwahashi M, Puljak L, Simon FR, Kilic G, Fitz JG, Friedman JE. Increased phosphoenolpyruvate carboxykinase gene expression and steatosis during hepatitis C virus subgenome replication: role of nonstructural component 5A and CCAAT/enhancer-binding protein ß. J Biol Chem. 2012 Oct 26; 287(44):37340-51.
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