 Proto-Oncogene Proteins c-jun
"Proto-Oncogene Proteins c-jun" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Cellular DNA-binding proteins encoded by the c-jun genes (GENES, JUN). They are involved in growth-related transcriptional control. There appear to be three distinct functions: dimerization (with c-fos), DNA-binding, and transcriptional activation. Oncogenic transformation can take place by constitutive expression of c-jun.
| Descriptor ID |
D016755
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| MeSH Number(s) |
D12.776.260.108.820 D12.776.624.664.700.182 D12.776.660.763 D12.776.930.127.820
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| Concept/Terms |
Proto-Oncogene Proteins c-jun- Proto-Oncogene Proteins c-jun
- Proto Oncogene Proteins c jun
- c-jun Proteins
- c jun Proteins
- fos-Associated Protein p39
- fos Associated Protein p39
- jun Proto-Oncogene Product p39
- jun Proto Oncogene Product p39
- jun Proto-Oncogene Proteins
- jun Proto Oncogene Proteins
- p39 c-jun
- p39 c jun
- p39(c-jun)
- Proto-Oncogene Products c-jun
- Proto Oncogene Products c jun
- c-fos-Associated Protein p39
- c fos Associated Protein p39
- Proto-Oncogene Proteins jun
- Proto Oncogene Proteins jun
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Below are MeSH descriptors whose meaning is more general than "Proto-Oncogene Proteins c-jun".
Below are MeSH descriptors whose meaning is more specific than "Proto-Oncogene Proteins c-jun".
This graph shows the total number of publications written about "Proto-Oncogene Proteins c-jun" by people in this website by year, and whether "Proto-Oncogene Proteins c-jun" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
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| 1992 | 0 | 2 | 2 | | 1993 | 0 | 3 | 3 | | 1994 | 2 | 2 | 4 | | 1996 | 1 | 1 | 2 | | 1997 | 1 | 1 | 2 | | 1998 | 0 | 3 | 3 | | 1999 | 2 | 1 | 3 | | 2000 | 1 | 0 | 1 | | 2001 | 4 | 0 | 4 | | 2002 | 0 | 2 | 2 | | 2003 | 0 | 1 | 1 | | 2004 | 2 | 2 | 4 | | 2005 | 3 | 2 | 5 | | 2006 | 0 | 2 | 2 | | 2008 | 1 | 1 | 2 | | 2009 | 1 | 0 | 1 | | 2010 | 1 | 2 | 3 | | 2012 | 0 | 1 | 1 | | 2013 | 1 | 0 | 1 | | 2014 | 1 | 0 | 1 | | 2017 | 1 | 1 | 2 | | 2018 | 1 | 0 | 1 |
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Below are the most recent publications written about "Proto-Oncogene Proteins c-jun" by people in Profiles.
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Kessler BE, Mishall KM, Kellett MD, Clark EG, Pugazhenthi U, Pozdeyev N, Kim J, Tan AC, Schweppe RE. Resistance to Src inhibition alters the BRAF-mutant tumor secretome to promote an invasive phenotype and therapeutic escape through a FAK>p130Cas>c-Jun signaling axis. Oncogene. 2019 04; 38(14):2565-2579.
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Forghany Z, Robertson F, Lundby A, Olsen JV, Baker DA. Control of endothelial cell tube formation by Notch ligand intracellular domain interactions with activator protein 1 (AP-1). J Biol Chem. 2018 01 26; 293(4):1229-1242.
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Fechtner S, Singh A, Chourasia M, Ahmed S. Molecular insights into the differences in anti-inflammatory activities of green tea catechins on IL-1ß signaling in rheumatoid arthritis synovial fibroblasts. Toxicol Appl Pharmacol. 2017 08 15; 329:112-120.
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Walters RD, McSwiggen DT, Goodrich JA, Kugel JF. Selection and characterization of a DNA aptamer that can discriminate between cJun/cJun and cJun/cFos. PLoS One. 2014; 9(6):e101015.
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Walters RD, Drullinger LF, Kugel JF, Goodrich JA. NFATc2 recruits cJun homodimers to an NFAT site to synergistically activate interleukin-2 transcription. Mol Immunol. 2013 Nov; 56(1-2):48-56.
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Arvey A, Agius P, Noble WS, Leslie C. Sequence and chromatin determinants of cell-type-specific transcription factor binding. Genome Res. 2012 Sep; 22(9):1723-34.
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Ranji A, Shkriabai N, Kvaratskhelia M, Musier-Forsyth K, Boris-Lawrie K. Features of double-stranded RNA-binding domains of RNA helicase A are necessary for selective recognition and translation of complex mRNAs. J Biol Chem. 2011 Feb 18; 286(7):5328-37.
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Nguyen TN, Kim LJ, Walters RD, Drullinger LF, Lively TN, Kugel JF, Goodrich JA. The C-terminal region of human NFATc2 binds cJun to synergistically activate interleukin-2 transcription. Mol Immunol. 2010 Aug; 47(14):2314-22.
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Gu M, Raina K, Agarwal C, Agarwal R. Inositol hexaphosphate downregulates both constitutive and ligand-induced mitogenic and cell survival signaling, and causes caspase-mediated apoptotic death of human prostate carcinoma PC-3 cells. Mol Carcinog. 2010 Jan; 49(1):1-12.
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Guzman ML, Jordan CT. Lessons learned from the study of JunB: new insights for normal and leukemia stem cell biology. Cancer Cell. 2009 Apr 07; 15(4):252-4.
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