 Interleukin-4
"Interleukin-4" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A soluble factor produced by activated T-LYMPHOCYTES that induces the expression of MHC CLASS II GENES and FC RECEPTORS on B-LYMPHOCYTES and causes their proliferation and differentiation. It also acts on T-lymphocytes, MAST CELLS, and several other hematopoietic lineage cells.
| Descriptor ID |
D015847
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| MeSH Number(s) |
D12.644.276.374.465.186 D12.776.467.374.465.178 D23.529.374.465.186
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| Concept/Terms |
Interleukin-4- Interleukin-4
- Interleukin 4
- B-Cell Growth Factor-1
- B Cell Growth Factor 1
- B-Cell Growth Factor-I
- B Cell Growth Factor I
- B-Cell Proliferating Factor
- B Cell Proliferating Factor
- B-Cell Stimulating Factor-1
- B Cell Stimulating Factor 1
- B-Cell Stimulatory Factor 1
- B-Cell Stimulatory Factor-1
- BCGF-1
- Binetrakin
- BSF-1
- IL-4
- IL4
- Mast Cell Growth Factor-2
- Mast Cell Growth Factor 2
- MCGF-2
- B Cell Stimulatory Factor-1
- B Cell Stimulatory Factor 1
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Below are MeSH descriptors whose meaning is more general than "Interleukin-4".
Below are MeSH descriptors whose meaning is more specific than "Interleukin-4".
This graph shows the total number of publications written about "Interleukin-4" by people in this website by year, and whether "Interleukin-4" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1992 | 2 | 0 | 2 | | 1993 | 1 | 0 | 1 | | 1994 | 0 | 2 | 2 | | 1995 | 2 | 0 | 2 | | 1996 | 0 | 1 | 1 | | 1997 | 1 | 3 | 4 | | 1998 | 0 | 3 | 3 | | 1999 | 0 | 1 | 1 | | 2000 | 2 | 1 | 3 | | 2001 | 0 | 2 | 2 | | 2002 | 3 | 5 | 8 | | 2003 | 4 | 1 | 5 | | 2004 | 3 | 3 | 6 | | 2005 | 1 | 2 | 3 | | 2006 | 0 | 1 | 1 | | 2007 | 1 | 2 | 3 | | 2008 | 3 | 2 | 5 | | 2009 | 4 | 1 | 5 | | 2010 | 2 | 6 | 8 | | 2011 | 2 | 0 | 2 | | 2012 | 0 | 3 | 3 | | 2013 | 1 | 5 | 6 | | 2014 | 3 | 4 | 7 | | 2015 | 3 | 5 | 8 | | 2016 | 0 | 3 | 3 | | 2017 | 0 | 1 | 1 | | 2018 | 3 | 0 | 3 | | 2019 | 1 | 1 | 2 | | 2020 | 2 | 1 | 3 | | 2021 | 1 | 1 | 2 | | 2022 | 0 | 1 | 1 |
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Below are the most recent publications written about "Interleukin-4" by people in Profiles.
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Havele SA, Khurana MC, McMahon P, Murthy AS, Perman MJ, Treat JR. Safety of dupilumab in a 5-month-old infant with severe atopic dermatitis. Pediatr Dermatol. 2022 Mar; 39(2):291-294.
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Leyva-Castillo JM, Das M, Kane J, Strakosha M, Singh S, Wong DSH, Horswill AR, Karasuyama H, Brombacher F, Miller LS, Geha RS. Basophil-derived IL-4 promotes cutaneous Staphylococcus aureus infection. JCI Insight. 2021 11 08; 6(21).
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Kopper TJ, Zhang B, Bailey WM, Bethel KE, Gensel JC. The effects of myelin on macrophage activation are phenotypic specific via cPLA2 in the context of spinal cord injury inflammation. Sci Rep. 2021 03 18; 11(1):6341.
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Tomar S, Ganesan V, Sharma A, Zeng C, Waggoner L, Smith A, Kim CH, Licona-Limón P, Reinhardt RL, Flavell RA, Wang YH, Hogan SP. IL-4-BATF signaling directly modulates IL-9 producing mucosal mast cell (MMC9) function in experimental food allergy. J Allergy Clin Immunol. 2021 01; 147(1):280-295.
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Coverstone AM, Seibold MA, Peters MC. Diagnosis and Management of T2-High Asthma. J Allergy Clin Immunol Pract. 2020 02; 8(2):442-450.
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Loupy KM, Lee T, Zambrano CA, Elsayed AI, D'Angelo HM, Fonken LK, Frank MG, Maier SF, Lowry CA. Alzheimer's Disease: Protective Effects of Mycobacterium vaccae, a Soil-Derived Mycobacterium with Anti-Inflammatory and Anti-Tubercular Properties, on the Proteomic Profiles of Plasma and Cerebrospinal Fluid in Rats. J Alzheimers Dis. 2020; 78(3):965-987.
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Boorgula MP, Taub MA, Rafaels N, Daya M, Campbell M, Chavan S, Shetty A, Cheadle C, Barkataki S, Fan J, David G, Beaty TH, Ruczinski I, Hanifin J, Schneider LC, Gallo RL, Paller AS, Beck LA, Leung DY, Mathias RA, Barnes KC. Replicated methylation changes associated with eczema herpeticum and allergic response. Clin Epigenetics. 2019 08 23; 11(1):122.
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Svedberg FR, Brown SL, Krauss MZ, Campbell L, Sharpe C, Clausen M, Howell GJ, Clark H, Madsen J, Evans CM, Sutherland TE, Ivens AC, Thornton DJ, Grencis RK, Hussell T, Cunoosamy DM, Cook PC, MacDonald AS. The lung environment controls alveolar macrophage metabolism and responsiveness in type 2 inflammation. Nat Immunol. 2019 05; 20(5):571-580.
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Miller CN, Proekt I, von Moltke J, Wells KL, Rajpurkar AR, Wang H, Rattay K, Khan IS, Metzger TC, Pollack JL, Fries AC, Lwin WW, Wigton EJ, Parent AV, Kyewski B, Erle DJ, Hogquist KA, Steinmetz LM, Locksley RM, Anderson MS. Thymic tuft cells promote an IL-4-enriched medulla and shape thymocyte development. Nature. 2018 07; 559(7715):627-631.
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Berdyshev E, Goleva E, Bronova I, Dyjack N, Rios C, Jung J, Taylor P, Jeong M, Hall CF, Richers BN, Norquest KA, Zheng T, Seibold MA, Leung DY. Lipid abnormalities in atopic skin are driven by type 2 cytokines. JCI Insight. 2018 02 22; 3(4).
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