STAT3 Transcription Factor
"STAT3 Transcription Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A signal transducer and activator of transcription that mediates cellular responses to INTERLEUKIN-6 family members. STAT3 is constitutively activated in a variety of TUMORS and is a major downstream transducer for the CYTOKINE RECEPTOR GP130.
Descriptor ID |
D050796
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MeSH Number(s) |
D12.644.360.024.342.300 D12.776.157.057.186.300 D12.776.476.024.430.300 D12.776.930.840.300
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Concept/Terms |
STAT3 Transcription Factor- STAT3 Transcription Factor
- Transcription Factor, STAT3
- LIF-Response Factor
- LIF Response Factor
- Acute-Phase Response Factor
- Acute Phase Response Factor
- Response Factor, Acute-Phase
- APRF Transcription Factor
- Transcription Factor, APRF
- Signal Transducer and Activator of Transcription 3
- IL6-Response Factor
- IL6 Response Factor
- STAT3 Protein
STAT3b Transcription Factor- STAT3b Transcription Factor
- Transcription Factor, STAT3b
- Stat3beta Transcription Factor
- Transcription Factor, Stat3beta
STAT3a Transcription Factor- STAT3a Transcription Factor
- Transcription Factor, STAT3a
- Stat3alpha Transcription Factor
- Transcription Factor, Stat3alpha
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Below are MeSH descriptors whose meaning is more general than "STAT3 Transcription Factor".
Below are MeSH descriptors whose meaning is more specific than "STAT3 Transcription Factor".
This graph shows the total number of publications written about "STAT3 Transcription Factor" by people in this website by year, and whether "STAT3 Transcription Factor" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
Year | Major Topic | Minor Topic | Total |
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1997 | 0 | 1 | 1 | 1998 | 0 | 1 | 1 | 2000 | 0 | 1 | 1 | 2001 | 0 | 1 | 1 | 2002 | 0 | 2 | 2 | 2003 | 0 | 1 | 1 | 2004 | 0 | 2 | 2 | 2005 | 1 | 1 | 2 | 2006 | 1 | 1 | 2 | 2007 | 4 | 3 | 7 | 2008 | 2 | 1 | 3 | 2009 | 3 | 2 | 5 | 2010 | 1 | 4 | 5 | 2011 | 5 | 5 | 10 | 2012 | 3 | 1 | 4 | 2013 | 4 | 6 | 10 | 2014 | 7 | 5 | 12 | 2015 | 2 | 4 | 6 | 2016 | 8 | 0 | 8 | 2017 | 0 | 1 | 1 | 2018 | 4 | 2 | 6 | 2019 | 3 | 3 | 6 | 2020 | 2 | 1 | 3 | 2021 | 7 | 2 | 9 | 2022 | 1 | 3 | 4 |
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Below are the most recent publications written about "STAT3 Transcription Factor" by people in Profiles.
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Roach CM, Bidne KL, Romoser MR, Ross JW, Baumgard LH, Keating AF. Impact of heat stress on prolactin-mediated ovarian JAK-STAT signaling in postpubertal gilts. J Anim Sci. 2022 Jul 01; 100(7).
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Kenchappa RS, Dovas A, Argenziano MG, Meyer CT, Stopfer LE, Banu MA, Pereira B, Griffith J, Mohammad A, Talele S, Haddock A, Zarco N, Elmquist W, White F, Quaranta V, Sims P, Canoll P, Rosenfeld SS. Activation of STAT3 through combined SRC and EGFR signaling drives resistance to a mitotic kinesin inhibitor in glioblastoma. Cell Rep. 2022 06 21; 39(12):110991.
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Piper M, Van Court B, Mueller A, Watanabe S, Bickett T, Bhatia S, Darragh LB, Mayeda M, Nguyen D, Gadwa J, Knitz M, Corbo S, Morgan R, Lee JJ, Dent A, Goodman K, Messersmith W, Schulick R, Del Chiaro M, Zhu Y, Kedl RM, Lenz L, Karam SD. Targeting Treg-Expressed STAT3 Enhances NK-Mediated Surveillance of Metastasis and Improves Therapeutic Response in Pancreatic Adenocarcinoma. Clin Cancer Res. 2022 Mar 01; 28(5):1013-1026.
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Amaya ML, Inguva A, Pei S, Jones C, Krug A, Ye H, Minhajuddin M, Winters A, Furtek SL, Gamboni F, Stevens B, D'Alessandro A, Pollyea DA, Reigan P, Jordan CT. The STAT3-MYC axis promotes survival of leukemia stem cells by regulating SLC1A5 and oxidative phosphorylation. Blood. 2022 01 27; 139(4):584-596.
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Bickett TE, Knitz MW, Piper M, Oweida AJ, Gadwa J, Darragh LB, Nguyen D, Bhatia S, Bhuvane S, Phan AV, Van Court B, Corbo S, Pham T, Dent AL, Lenz L, Karam SD. Dichotomous effects of cellular expression of STAT3 on tumor growth of HNSCC. Mol Ther. 2022 03 02; 30(3):1149-1162.
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Peron M, Dinarello A, Meneghetti G, Martorano L, Betto RM, Facchinello N, Tesoriere A, Tiso N, Martello G, Argenton F. Y705 and S727 are required for the mitochondrial import and transcriptional activities of STAT3, and for regulation of stem cell proliferation. Development. 2021 09 01; 148(17).
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Tengesdal IW, Dinarello A, Powers NE, Burchill MA, Joosten LAB, Marchetti C, Dinarello CA. Tumor NLRP3-Derived IL-1ß Drives the IL-6/STAT3 Axis Resulting in Sustained MDSC-Mediated Immunosuppression. Front Immunol. 2021; 12:661323.
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Patel SB, Nemkov T, Stefanoni D, Benavides GA, Bassal MA, Crown BL, Matkins VR, Camacho V, Kuznetsova V, Hoang AT, Tenen DE, Wolock SL, Park J, Ying L, Yue Z, Chen JY, Yang H, Tenen DG, Ferrell PB, Lu R, Darley-Usmar V, D'Alessandro A, Bhatia R, Welner RS. Metabolic alterations mediated by STAT3 promotes drug persistence in CML. Leukemia. 2021 12; 35(12):3371-3382.
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Sun F, Wang G, Pradhan A, Xu K, Gomez-Arroyo J, Zhang Y, Kalin GT, Deng Z, Vagnozzi RJ, He H, Dunn AW, Wang Y, York AJ, Hegde RS, Woods JC, Kalin TV, Molkentin JD, Kalinichenko VV. Nanoparticle Delivery of STAT3 Alleviates Pulmonary Hypertension in a Mouse Model of Alveolar Capillary Dysplasia. Circulation. 2021 08 17; 144(7):539-555.
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Pingali P, Wu YJ, Boothello R, Sharon C, Li H, Sistla S, Sankaranarayanan NV, Desai UR, Le AT, Doebele RC, Muldoon LL, Patel BB, Neuwelt A. High dose acetaminophen inhibits STAT3 and has free radical independent anti-cancer stem cell activity. Neoplasia. 2021 03; 23(3):348-359.
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