 Chemical and Drug Induced Liver Injury
"Chemical and Drug Induced Liver Injury" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment.
| Descriptor ID |
D056486
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| MeSH Number(s) |
C06.552.195 C25.100.562 C25.723.260
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| Concept/Terms |
Chemically-Induced Liver Toxicity- Chemically-Induced Liver Toxicity
- Chemically Induced Liver Toxicity
- Chemically-Induced Liver Toxicities
- Liver Toxicities, Chemically-Induced
- Liver Toxicity, Chemically-Induced
- Toxicities, Chemically-Induced Liver
- Toxicity, Chemically-Induced Liver
Drug-Induced Acute Liver Injury- Drug-Induced Acute Liver Injury
- Drug Induced Acute Liver Injury
- Liver Injury, Drug-Induced, Acute
- Acute Liver Injury, Drug-Induced
- Acute Liver Injury, Drug Induced
Hepatitis, Toxic- Hepatitis, Toxic
- Toxic Hepatitis
- Hepatitides, Toxic
- Toxic Hepatitides
Drug-Induced Liver Disease- Drug-Induced Liver Disease
- Disease, Drug-Induced Liver
- Diseases, Drug-Induced Liver
- Drug Induced Liver Disease
- Drug-Induced Liver Diseases
- Liver Disease, Drug-Induced
- Liver Diseases, Drug-Induced
- Drug-Induced Liver Injury
- Drug Induced Liver Injury
- Drug-Induced Liver Injuries
- Injuries, Drug-Induced Liver
- Injury, Drug-Induced Liver
- Liver Injuries, Drug-Induced
- Liver Injury, Drug-Induced
- Liver Injury, Drug Induced
Hepatitis, Drug-Induced- Hepatitis, Drug-Induced
- Drug-Induced Hepatitides
- Drug-Induced Hepatitis
- Hepatitides, Drug-Induced
- Hepatitis, Drug Induced
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Below are MeSH descriptors whose meaning is more general than "Chemical and Drug Induced Liver Injury".
Below are MeSH descriptors whose meaning is more specific than "Chemical and Drug Induced Liver Injury".
This graph shows the total number of publications written about "Chemical and Drug Induced Liver Injury" by people in this website by year, and whether "Chemical and Drug Induced Liver Injury" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1992 | 1 | 0 | 1 | | 1995 | 2 | 0 | 2 | | 1996 | 1 | 2 | 3 | | 1998 | 2 | 0 | 2 | | 2000 | 1 | 1 | 2 | | 2001 | 1 | 0 | 1 | | 2002 | 1 | 1 | 2 | | 2003 | 5 | 3 | 8 | | 2004 | 3 | 0 | 3 | | 2005 | 1 | 1 | 2 | | 2006 | 1 | 1 | 2 | | 2007 | 3 | 1 | 4 | | 2008 | 1 | 2 | 3 | | 2009 | 2 | 2 | 4 | | 2010 | 5 | 0 | 5 | | 2011 | 2 | 2 | 4 | | 2012 | 5 | 1 | 6 | | 2013 | 2 | 1 | 3 | | 2014 | 5 | 1 | 6 | | 2015 | 0 | 1 | 1 | | 2016 | 2 | 2 | 4 | | 2017 | 1 | 0 | 1 | | 2018 | 4 | 1 | 5 | | 2019 | 4 | 0 | 4 | | 2020 | 1 | 1 | 2 |
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Below are the most recent publications written about "Chemical and Drug Induced Liver Injury" by people in Profiles.
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Akakpo JY, Ramachandran A, Orhan H, Curry SC, Rumack BH, Jaeschke H. 4-methylpyrazole protects against acetaminophen-induced acute kidney injury. Toxicol Appl Pharmacol. 2020 12 15; 409:115317.
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Feldman AG, Parsons JA, Dutmer CM, Veerapandiyan A, Hafberg E, Maloney N, Mack CL. Subacute Liver Failure Following Gene Replacement Therapy for Spinal Muscular Atrophy Type 1. J Pediatr. 2020 10; 225:252-258.e1.
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Schimmel J, Dart RC. Kratom (Mitragyna Speciosa) Liver Injury: A Comprehensive Review. Drugs. 2020 Feb; 80(3):263-283.
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Akakpo JY, Ramachandran A, Duan L, Schaich MA, Jaeschke MW, Freudenthal BD, Ding WX, Rumack BH, Jaeschke H. Delayed Treatment With 4-Methylpyrazole Protects Against Acetaminophen Hepatotoxicity in Mice by Inhibition of c-Jun n-Terminal Kinase. Toxicol Sci. 2019 07 01; 170(1):57-68.
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Pepe-Mooney BJ, Dill MT, Alemany A, Ordovas-Montanes J, Matsushita Y, Rao A, Sen A, Miyazaki M, Anakk S, Dawson PA, Ono N, Shalek AK, van Oudenaarden A, Camargo FD. Single-Cell Analysis of the Liver Epithelium Reveals Dynamic Heterogeneity and an Essential Role for YAP in Homeostasis and Regeneration. Cell Stem Cell. 2019 07 03; 25(1):23-38.e8.
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Shavadia JS, Sharma A, Gu X, Neaton J, DeLeve L, Holmes D, Home P, Eckel RH, Watkins PB, Granger CB. Determination of fasiglifam-induced liver toxicity: Insights from the data monitoring committee of the fasiglifam clinical trials program. Clin Trials. 2019 06; 16(3):253-262.
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Mutsaers A, Green JP, Sivilotti MLA, Yarema MC, Tucker D, Johnson DW, Spyker DA, Rumack BH. Changing nomogram risk zone classification with serial testing after acute acetaminophen overdose: a retrospective database analysis. Clin Toxicol (Phila). 2019 06; 57(6):380-386.
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Neil D, Clark RV, Magee M, Billiard J, Chan A, Xue Z, Russell A. GSK2881078, a SARM, Produces Dose-Dependent Increases in Lean Mass in Healthy Older Men and Women. J Clin Endocrinol Metab. 2018 09 01; 103(9):3215-3224.
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Akakpo JY, Ramachandran A, Kandel SE, Ni HM, Kumer SC, Rumack BH, Jaeschke H. 4-Methylpyrazole protects against acetaminophen hepatotoxicity in mice and in primary human hepatocytes. Hum Exp Toxicol. 2018 Dec; 37(12):1310-1322.
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McGreal SR, Bhushan B, Walesky C, McGill MR, Lebofsky M, Kandel SE, Winefield RD, Jaeschke H, Zachara NE, Zhang Z, Tan EP, Slawson C, Apte U. Modulation of O-GlcNAc Levels in the Liver Impacts Acetaminophen-Induced Liver Injury by Affecting Protein Adduct Formation and Glutathione Synthesis. Toxicol Sci. 2018 04 01; 162(2):599-610.
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