Semaphorins
"Semaphorins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of proteins that mediate AXONAL GUIDANCE. Semaphorins act as repulsive cues for neuronal GROWTH CONES and bind to receptors on their filopodia. At least 20 different molecules have been described and divided into eight classes based on domain organization and species of origin. Classes 1 and 2 are invertebrate, classes 3-7 are vertebrate, and class V are viral. Semaphorins may be secreted (classes 2, 3, and V), transmembrane (classes 1, 4, 5, and 6), or membrane-anchored (class 7). All semaphorins possess a common 500-amino acid extracellular domain which is critical for receptor binding and specificity, and is also found in plexins and scatter factor receptors. Their C termini are class-specific and may contain additional sequence motifs.
Descriptor ID |
D039961
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MeSH Number(s) |
D12.644.276.923 D12.776.467.923 D23.529.923
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Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Semaphorins".
Below are MeSH descriptors whose meaning is more specific than "Semaphorins".
This graph shows the total number of publications written about "Semaphorins" by people in this website by year, and whether "Semaphorins" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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2008 | 2 | 0 | 2 | 2009 | 1 | 0 | 1 | 2010 | 1 | 0 | 1 | 2013 | 0 | 1 | 1 | 2016 | 2 | 0 | 2 | 2018 | 1 | 0 | 1 | 2019 | 1 | 0 | 1 | 2020 | 1 | 1 | 2 |
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Below are the most recent publications written about "Semaphorins" by people in Profiles.
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Borges VF, Lyons TR, Germain D, Schedin P. Postpartum Involution and Cancer: An Opportunity for Targeted Breast Cancer Prevention and Treatments? Cancer Res. 2020 05 01; 80(9):1790-1798.
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Tarullo SE, Hill RC, Hansen KC, Behbod F, Borges VF, Nelson AC, Lyons TR. Postpartum breast cancer progression is driven by semaphorin 7a-mediated invasion and survival. Oncogene. 2020 03; 39(13):2772-2785.
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van der Klaauw AA, Croizier S, Mendes de Oliveira E, Stadler LKJ, Park S, Kong Y, Banton MC, Tandon P, Hendricks AE, Keogh JM, Riley SE, Papadia S, Henning E, Bounds R, Bochukova EG, Mistry V, O'Rahilly S, Simerly RB, Minchin JEN, Barroso I, Jones EY, Bouret SG, Farooqi IS. Human Semaphorin 3 Variants Link Melanocortin Circuit Development and Energy Balance. Cell. 2019 02 07; 176(4):729-742.e18.
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Elder AM, Tamburini BAJ, Crump LS, Black SA, Wessells VM, Schedin PJ, Borges VF, Lyons TR. Semaphorin 7A Promotes Macrophage-Mediated Lymphatic Remodeling during Postpartum Mammary Gland Involution and in Breast Cancer. Cancer Res. 2018 11 15; 78(22):6473-6485.
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Eckle T. New "Guidance" for the Treatment of Hepatic Ischemia Reperfusion Injury Through Semaphorins and Plexins. Crit Care Med. 2016 08; 44(8):1623-4.
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Black SA, Nelson AC, Gurule NJ, Futscher BW, Lyons TR. Semaphorin 7a exerts pleiotropic effects to promote breast tumor progression. Oncogene. 2016 09 29; 35(39):5170-8.
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Saben J, Zhong Y, McKelvey S, Dajani NK, Andres A, Badger TM, Gomez-Acevedo H, Shankar K. A comprehensive analysis of the human placenta transcriptome. Placenta. 2014 Feb; 35(2):125-31.
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Eriksson EM, Milush JM, Ho EL, Batista MD, Holditch SJ, Keh CE, Norris PJ, Keating SM, Deeks SG, Hunt PW, Martin JN, Rosenberg MG, Hecht FM, Nixon DF. Expansion of CD8+ T cells lacking Sema4D/CD100 during HIV-1 infection identifies a subset of T cells with decreased functional capacity. Blood. 2012 Jan 19; 119(3):745-55.
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Wannemacher KM, Zhu L, Jiang H, Fong KP, Stalker TJ, Lee D, Tran AN, Neeves KB, Maloney S, Kumanogoh A, Kikutani H, Hammer DA, Diamond SL, Brass LF. Diminished contact-dependent reinforcement of Syk activation underlies impaired thrombus growth in mice lacking Semaphorin 4D. Blood. 2010 Dec 16; 116(25):5707-15.
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Zhu L, Stalker TJ, Fong KP, Jiang H, Tran A, Crichton I, Lee EK, Neeves KB, Maloney SF, Kikutani H, Kumanogoh A, Pure E, Diamond SL, Brass LF. Disruption of SEMA4D ameliorates platelet hypersensitivity in dyslipidemia and confers protection against the development of atherosclerosis. Arterioscler Thromb Vasc Biol. 2009 Jul; 29(7):1039-45.
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