 Low Density Lipoprotein Receptor-Related Protein-2
"Low Density Lipoprotein Receptor-Related Protein-2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An LDL-RECEPTOR RELATED PROTEIN found in the neuroepithelium and in proximal tubular cells of the kidney. It is considered a multiligand receptor in that it binds to a variety of ligands with relatively high affinity and may function in mediating the uptake and lysosomal degradation of macromolecules such as: LIPOPROTEINS; ENDOPEPTIDASES; and PROTEASE INHIBITORS.
| Descriptor ID |
D026561
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| MeSH Number(s) |
D12.776.526.200 D12.776.543.750.710.450.500.200 D23.050.422.500.500
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| Concept/Terms |
Low Density Lipoprotein Receptor-Related Protein-2- Low Density Lipoprotein Receptor-Related Protein-2
- Low Density Lipoprotein Receptor Related Protein 2
- LDL-Receptor Related Protein 2
- LDL Receptor Related Protein 2
- Low-Density Lipoprotein Receptor-Related Protein-2
- LRP-2 Receptor
- LRP 2 Receptor
- Megalin
- Heyman's Nephritis Antigen GP330
- Renal Glycoprotein GP330
- GP330, Renal Glycoprotein
- Glycoprotein GP330, Renal
- Antigen GP 330, Nephritis
- Glycoprotein 330
- GP330 Antigen
- Heymann Nephritis Antigen GP330
- Nephritis Antigen (GP330)
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Below are MeSH descriptors whose meaning is more general than "Low Density Lipoprotein Receptor-Related Protein-2".
Below are MeSH descriptors whose meaning is more specific than "Low Density Lipoprotein Receptor-Related Protein-2".
This graph shows the total number of publications written about "Low Density Lipoprotein Receptor-Related Protein-2" by people in this website by year, and whether "Low Density Lipoprotein Receptor-Related Protein-2" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2007 | 0 | 2 | 2 | | 2012 | 1 | 0 | 1 | | 2014 | 0 | 1 | 1 | | 2017 | 2 | 0 | 2 |
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Below are the most recent publications written about "Low Density Lipoprotein Receptor-Related Protein-2" by people in Profiles.
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Vohwinkel CU, Buch?ckert Y, Al-Tamari HM, Mazzocchi LC, Eltzschig HK, Mayer K, Morty RE, Herold S, Seeger W, Pullamsetti SS, Vad?sz I. Restoration of Megalin-Mediated Clearance of Alveolar Protein as a Novel Therapeutic Approach for Acute Lung Injury. Am J Respir Cell Mol Biol. 2017 11; 57(5):589-602.
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Mazzocchi LC, Vohwinkel CU, Mayer K, Herold S, Morty RE, Seeger W, Vad?sz I. TGF-? inhibits alveolar protein transport by promoting shedding, regulated intramembrane proteolysis, and transcriptional downregulation of megalin. Am J Physiol Lung Cell Mol Physiol. 2017 Nov 01; 313(5):L807-L824.
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Dickson LE, Wagner MC, Sandoval RM, Molitoris BA. The proximal tubule and albuminuria: really! J Am Soc Nephrol. 2014 Mar; 25(3):443-53.
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Buch?ckert Y, Rummel S, Vohwinkel CU, Gabrielli NM, Grzesik BA, Mayer K, Herold S, Morty RE, Seeger W, Vad?sz I. Megalin mediates transepithelial albumin clearance from the alveolar space of intact rabbit lungs. J Physiol. 2012 Oct 15; 590(20):5167-81.
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Russo LM, Sandoval RM, Brown D, Molitoris BA, Comper WD. Controversies in nephrology: response to 'renal albumin handling, facts, and artifacts'. Kidney Int. 2007 Nov; 72(10):1195-7.
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Russo LM, Sandoval RM, McKee M, Osicka TM, Collins AB, Brown D, Molitoris BA, Comper WD. The normal kidney filters nephrotic levels of albumin retrieved by proximal tubule cells: retrieval is disrupted in nephrotic states. Kidney Int. 2007 Mar; 71(6):504-13.
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