 Cytochrome P-450 Enzyme System
"Cytochrome P-450 Enzyme System" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A superfamily of hundreds of closely related HEMEPROTEINS found throughout the phylogenetic spectrum, from animals, plants, fungi, to bacteria. They include numerous complex monooxygenases (MIXED FUNCTION OXYGENASES). In animals, these P-450 enzymes serve two major functions: (1) biosynthesis of steroids, fatty acids, and bile acids; (2) metabolism of endogenous and a wide variety of exogenous substrates, such as toxins and drugs (BIOTRANSFORMATION). They are classified, according to their sequence similarities rather than functions, into CYP gene families (>40% homology) and subfamilies (>59% homology). For example, enzymes from the CYP1, CYP2, and CYP3 gene families are responsible for most drug metabolism.
| Descriptor ID |
D003577
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| MeSH Number(s) |
D08.244.453 D08.811.682.690.708.170 D12.776.422.220.453
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| Concept/Terms |
Cytochrome P-450 Enzyme System- Cytochrome P-450 Enzyme System
- Cytochrome P 450 Enzyme System
- Cytochrome P450
- P-450 Enzymes
- Enzymes, P-450
- P 450 Enzymes
- P450 Enzymes
- Enzymes, P450
- CYP450 Family
- Cytochrome P450 Superfamily
- Superfamily, Cytochrome P450
- Cytochrome P-450 Superfamily
- Cytochrome P 450 Superfamily
- Superfamily, Cytochrome P-450
- Cytochrome p450 Families
- Cytochrome P-450 Families
- Cytochrome P 450 Families
- CYP450 Superfamily
- Superfamily, CYP450
- Cytochrome P-450
- Cytochrome P 450
- Cytochrome P-450 Enzymes
- Cytochrome P 450 Enzymes
- Enzymes, Cytochrome P-450
- P-450 Enzymes, Cytochrome
Cytochrome P-450 Monooxygenase- Cytochrome P-450 Monooxygenase
- Cytochrome P 450 Monooxygenase
- Monooxygenase, Cytochrome P-450
- Cytochrome P-450-Dependent Monooxygenase
- Cytochrome P 450 Dependent Monooxygenase
- Monooxygenase, Cytochrome P-450-Dependent
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Below are MeSH descriptors whose meaning is more general than "Cytochrome P-450 Enzyme System".
Below are MeSH descriptors whose meaning is more specific than "Cytochrome P-450 Enzyme System".
This graph shows the total number of publications written about "Cytochrome P-450 Enzyme System" by people in this website by year, and whether "Cytochrome P-450 Enzyme System" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 1995 | 1 | 0 | 1 | | 1998 | 1 | 0 | 1 | | 1999 | 2 | 0 | 2 | | 2000 | 0 | 1 | 1 | | 2001 | 0 | 3 | 3 | | 2002 | 1 | 3 | 4 | | 2003 | 0 | 1 | 1 | | 2004 | 3 | 0 | 3 | | 2005 | 3 | 1 | 4 | | 2006 | 6 | 2 | 8 | | 2007 | 1 | 0 | 1 | | 2008 | 3 | 2 | 5 | | 2009 | 0 | 1 | 1 | | 2010 | 2 | 1 | 3 | | 2011 | 1 | 0 | 1 | | 2012 | 2 | 0 | 2 | | 2013 | 1 | 0 | 1 | | 2014 | 2 | 1 | 3 | | 2015 | 0 | 1 | 1 | | 2016 | 0 | 3 | 3 | | 2018 | 1 | 2 | 3 | | 2021 | 1 | 0 | 1 | | 2022 | 1 | 0 | 1 |
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Below are the most recent publications written about "Cytochrome P-450 Enzyme System" by people in Profiles.
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Tooker BC, Kandel SE, Work HM, Lampe JN. Pseudomonas aeruginosa cytochrome P450 CYP168A1 is a fatty acid hydroxylase that metabolizes arachidonic acid to the vasodilator 19-HETE. J Biol Chem. 2022 03; 298(3):101629.
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Muchlinski A, Jia M, Tiedge K, Fell JS, Pelot KA, Chew L, Davisson D, Chen Y, Siegel J, Lovell JT, Zerbe P. Cytochrome P450-catalyzed biosynthesis of furanoditerpenoids in the bioenergy crop switchgrass (Panicum virgatum L.). Plant J. 2021 11; 108(4):1053-1068.
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Shokati T, Hartmann M, Davari B, Klawitter J, Klawitter J, Christians U. Temsirolimus metabolic pathways revisited. Xenobiotica. 2020 Jun; 50(6):640-653.
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Campbell NV, Weitzenkamp DA, Campbell IL, Schmidt RF, Hicks C, Morgan MJ, Irwin DC, Tentler JJ. "Omics" data integration and functional analyses link Enoyl-CoA hydratase, short chain 1 to drug refractory dilated cardiomyopathy. BMC Med Genomics. 2018 Dec 12; 11(1):110.
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New ML, White CM, McGonigle P, McArthur DG, Dwyer-Nield LD, Merrick DT, Keith RL, Tennis MA. Prostacyclin and EMT Pathway Markers for Monitoring Response to Lung Cancer Chemoprevention. Cancer Prev Res (Phila). 2018 10; 11(10):643-654.
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Mallinson SJB, Machovina MM, Silveira RL, Garcia-Borràs M, Gallup N, Johnson CW, Allen MD, Skaf MS, Crowley MF, Neidle EL, Houk KN, Beckham GT, DuBois JL, McGeehan JE. A promiscuous cytochrome P450 aromatic O-demethylase for lignin bioconversion. Nat Commun. 2018 06 27; 9(1):2487.
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Tamosiuniene R, Manouvakhova O, Mesange P, Saito T, Qian J, Sanyal M, Lin YC, Nguyen LP, Luria A, Tu AB, Sante JM, Rabinovitch M, Fitzgerald DJ, Graham BB, Habtezion A, Voelkel NF, Aurelian L, Nicolls MR. Dominant Role for Regulatory T Cells in Protecting Females Against Pulmonary Hypertension. Circ Res. 2018 06 08; 122(12):1689-1702.
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Brooks KM, George JM, Kumar P. Drug interactions in HIV treatment: complementary & alternative medicines and over-the-counter products. Expert Rev Clin Pharmacol. 2017 Jan; 10(1):59-79.
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Tyagi V, Alwaseem H, O'Dwyer KM, Ponder J, Li QY, Jordan CT, Fasan R. Chemoenzymatic synthesis and antileukemic activity of novel C9- and C14-functionalized parthenolide analogs. Bioorg Med Chem. 2016 09 01; 24(17):3876-3886.
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Walker VJ, Griffin AP, Hammar DK, Hollenberg PF. Metabolism of Anandamide by Human Cytochrome P450 2J2 in the Reconstituted System and Human Intestinal Microsomes. J Pharmacol Exp Ther. 2016 06; 357(3):537-44.
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