Mice, Knockout
"Mice, Knockout" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
Descriptor ID |
D018345
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MeSH Number(s) |
B01.050.050.136.500.500 B01.050.150.900.649.313.992.635.505.500.550.455 B01.050.150.900.649.313.992.635.505.500.800.500
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Concept/Terms |
Mice, Knockout- Mice, Knockout
- Mice, Knock-out
- Knock-out Mice
- Mice, Knock out
- Mouse, Knockout
- Knockout Mouse
- Knockout Mice
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Below are MeSH descriptors whose meaning is more general than "Mice, Knockout".
Below are MeSH descriptors whose meaning is more specific than "Mice, Knockout".
This graph shows the total number of publications written about "Mice, Knockout" by people in this website by year, and whether "Mice, Knockout" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
Year | Major Topic | Minor Topic | Total |
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1995 | 0 | 2 | 2 | 1996 | 1 | 11 | 12 | 1997 | 0 | 13 | 13 | 1998 | 1 | 17 | 18 | 1999 | 1 | 16 | 17 | 2000 | 0 | 33 | 33 | 2001 | 1 | 43 | 44 | 2002 | 0 | 52 | 52 | 2003 | 0 | 47 | 47 | 2004 | 1 | 69 | 70 | 2005 | 2 | 72 | 74 | 2006 | 0 | 76 | 76 | 2007 | 0 | 74 | 74 | 2008 | 0 | 91 | 91 | 2009 | 2 | 98 | 100 | 2010 | 0 | 98 | 98 | 2011 | 0 | 98 | 98 | 2012 | 0 | 97 | 97 | 2013 | 0 | 123 | 123 | 2014 | 0 | 111 | 111 | 2015 | 0 | 111 | 111 | 2016 | 0 | 96 | 96 | 2017 | 0 | 81 | 81 | 2018 | 0 | 93 | 93 | 2019 | 0 | 82 | 82 | 2020 | 0 | 90 | 90 | 2021 | 0 | 69 | 69 | 2022 | 0 | 14 | 14 |
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Below are the most recent publications written about "Mice, Knockout" by people in Profiles.
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Monogue B, Chen Y, Sparks H, Behbehani R, Chai A, Rajic AJ, Massey A, Kleinschmidt-Demasters BK, Vermeren M, Kunath T, Beckham JD. Alpha-synuclein supports type 1 interferon signalling in neurons and brain tissue. Brain. 2022 10 21; 145(10):3622-3636.
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Wang Y, Tan L, Jiao K, Xue C, Tang Q, Jiang S, Ren Y, Chen H, El-Aziz TMA, Abdelazeem KNM, Yu Y, Zhao F, Zhu MX, Cao Z. Scutellarein attenuates atopic dermatitis by selectively inhibiting transient receptor potential vanilloid 3 channels. Br J Pharmacol. 2022 10; 179(20):4792-4808.
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Zhao Y, Riching AS, Knight WE, Chi C, Broadwell LJ, Du Y, Abdel-Hafiz M, Ambardekar AV, Irwin DC, Proenza C, Xu H, Leinwand LA, Walker LA, Woulfe KC, Bristow MR, Buttrick PM, Song K. Cardiomyocyte-Specific Long Noncoding RNA Regulates Alternative Splicing of the Triadin Gene in the Heart. Circulation. 2022 08 30; 146(9):699-714.
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Lucas CJ, Davenport BJ, Carpentier KS, Tinega AN, Morrison TE. Two Conserved Phenylalanine Residues in the E1 Fusion Loop of Alphaviruses Are Essential for Viral Infectivity. J Virol. 2022 05 11; 96(9):e0006422.
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Raghavan S, Kundumani-Sridharan V, Kumar S, White CW, Das KC. Thioredoxin Prevents Loss of UCP2 in Hyperoxia via MKK4-p38 MAPK-PGC1a Signaling and Limits Oxygen Toxicity. Am J Respir Cell Mol Biol. 2022 03; 66(3):323-336.
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Shull LC, Lencer ES, Kim HM, Goyama S, Kurokawa M, Costello JC, Jones K, Artinger KB. PRDM paralogs antagonistically balance Wnt/ß-catenin activity during craniofacial chondrocyte differentiation. Development. 2022 02 15; 149(4).
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Bagchi RA, Robinson EL, Hu T, Cao J, Hong JY, Tharp CA, Qasim H, Gavin KM, Pires da Silva J, Major JL, McConnell BK, Seto E, Lin H, McKinsey TA. Reversible lysine fatty acylation of an anchoring protein mediates adipocyte adrenergic signaling. Proc Natl Acad Sci U S A. 2022 02 15; 119(7).
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Li H, Trager LE, Liu X, Hastings MH, Xiao C, Guerra J, To S, Li G, Yeri A, Rodosthenous R, Silverman MG, Das S, Ambardekar AV, Bristow MR, González-Rosa JM, Rosenzweig A. lncExACT1 and DCHS2 Regulate Physiological and Pathological Cardiac Growth. Circulation. 2022 04 19; 145(16):1218-1233.
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Thompson B, Davidson EA, Chen Y, Orlicky DJ, Thompson DC, Vasiliou V. Oxidative stress induces inflammation of lens cells and triggers immune surveillance of ocular tissues. Chem Biol Interact. 2022 Mar 01; 355:109804.
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Peterson JN, Boackle SA, Taitano SH, Sang A, Lang J, Kelly M, Rahkola JT, Miranda AM, Sheridan RM, Thurman JM, Rao VK, Torres RM, Pelanda R. Elevated Detection of Dual Antibody B Cells Identifies Lupus Patients With B Cell-Reactive VH4-34 Autoantibodies. Front Immunol. 2022; 13:795209.
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